Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Lead Software Development Engineer
$133K - $190K *
Drive innovation as you lead the design and deployment of scalable AI-native platforms, blending advanced technologies with enterprise systems. Collaborate across teams to ensure high performance and...
2 weeks ago
Lead Software Development Engineer
$133K - $190K *
Join a team that's driving Mergers & Acquisitions success by leading Dynamics 365 configuration and customization efforts. Collaborate with stakeholders to optimize business processes and ensure seaml...
3 weeks ago
Senior Software Engineer - Data Infrastructure
$175K - $200K *
Optimize our data infrastructure platform by enhancing automation, observability, and stability. Drive architectural changes to support long-term service requirements while ensuring high throughput an...
2 weeks ago
Lead Software Engineer (Remote)
$126K - $157K *
Drive your career forward by leading complex software projects, collaborating with diverse teams, and leveraging cutting-edge technologies to deliver high-quality solutions that meet client needs and...
1 week ago
$139K - $235K *
Lead the development of innovative CX solutions using AI tools, enhancing workflows and integrations across platforms. Collaborate with cross-functional teams to deliver production-quality software an...
Today
$135K - $160K *
Take ownership of software engineering initiatives within established companies. Lead teams, modernize development processes, and enhance code quality while delivering impactful software solutions. Co...
5 days ago
Senior Software Engineer - External Products
$125K - $150K *
Deliver scalable backend services and APIs for scholarly content, enhancing search and discovery systems. Collaborate with cross-functional teams to optimize performance and reliability while integrat...
3 days ago
Manager - Software Development Engineering S 4D
$80K - $100K *
Unlock potential by leading a dynamic team of developers to deliver high-quality software solutions, collaborating with stakeholders, and driving strategic project initiatives while fostering a cultur...
2 weeks ago
Senior Software Engineer- Rust / C++
$94K - $176K *
Drive innovation in document processing by leading high-impact projects, shaping architecture, and optimizing performance in a queue-driven pipeline. Collaborate across teams to enhance AI products an...
2 weeks ago
$113K - $191K *
Empower innovation in safety technology by developing AI-driven solutions that enhance customer experiences and operational efficiency. Collaborate across teams to deliver scalable, impactful products...
Reposted today
Principal Software Engineer - Loom
$209K - $273K *
Drive innovation by owning customer-facing products end to end, leading technical strategy, and shaping product direction. Collaborate across teams to build AI-native experiences that enhance user eng...
1 week ago
Staff Software Engineer, Frontend
$138K - $165K *
Transform the future of pharmacy operations by leading the development of scalable, reliable front-end solutions. Collaborate with cross-functional teams to enhance user experiences and drive technica...
2 weeks ago
Software Engineer I - LLM Observability
$160K - $180K *
Empower your career by delivering AI observability solutions end-to-end. Collaborate with a cross-functional team to enhance user experiences and drive insights into AI systems, shaping the future of...
2 weeks ago
$150K - $200K *
Transform your career by leading innovative software solutions, guiding AI-driven development, and ensuring high-quality deliverables. Collaborate with cross-functional teams to shape the technical la...
2 weeks ago
Senior Software Engineer - Virtual Machines (RD222)
$125K - $150K *
Transform your career by owning complex software features that integrate virtual machines into a secure platform. Collaborate across teams to deliver innovative solutions while establishing strong eng...
1 week ago
$120K - $145K *
Innovate with us as a Senior Software Engineer, driving core feature development and automation across the stack. Collaborate with diverse teams to enhance scalability and performance in a dynamic, mi...
Reposted 2 weeks ago
Senior Software Engineer, Infrastructure Engineering
$190K - $267K *
Champion innovation by leading cross-functional teams to design and deliver scalable, high-performance infrastructure solutions that enhance reliability and efficiency across diverse applications and...
5 days ago
Staff Data Engineer, Core Migrations
$230K - $260K *
Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...
Reposted today
Senior Engineering Manager, Platform
$150K - $180K *
Lead and grow a high-performing platform engineering team, setting vision and roadmap while collaborating with cross-functional leaders to enhance product velocity and reliability for enterprise custo...
6 days ago
$120K - $200K *
Transform backend services and REST APIs in a collaborative environment. Leverage your software engineering skills to support cyber training initiatives, utilizing modern technologies and cloud infras...
2 weeks ago
Backend Software Engineer, SDK
$145K - $200K *
Transform your career by developing robust SDKs that empower customers globally. Collaborate with cross-functional teams to enhance performance and resiliency while contributing to open-source project...
2 weeks ago
Staff Software Engineer, Platform (DevEx)
$185K - $297K *
Innovate the future of software delivery by defining technical direction for a vital platform. Lead high-impact projects, set architecture standards, and mentor engineers in this hands-on role within...
Reposted 4 days ago
Senior Software Engineer, Fullstack (App Experience)
$173K - $233K *
Unlock innovative solutions as you collaborate across teams to enhance user experiences on mobile and web platforms. Drive impactful projects, support product development, and contribute to a thriving...
3 weeks ago
Software Engineer II- Full-stack Developer
$95K - $188K *
Drive the development of innovative cloud-native applications and AI features as a full-stack developer. Collaborate with senior engineers to enhance your skills while delivering impactful solutions i...
3 days ago
Software Engineer II- Full-stack Developer
$95K - $188K *
Unlock your potential as a full-stack developer, contributing to cloud-native applications and AI features. Collaborate with senior engineers, enhance your skills, and deliver impactful software solut...
3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.