Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$89K - $107K *

Drive innovation in application integration by designing and supporting secure data flows across enterprise systems. Collaborate with teams to enhance performance and ensure data integrity while lever...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Elevate the future of fresh food by designing innovative sous vide protein products. Collaborate with cross-functional teams to create exceptional culinary experiences that enhance nutrition, convenie...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$108K - $130K *

Elevate manufacturing excellence by providing technical leadership in complex processes, enhancing production efficiency, and implementing advanced technologies while collaborating across functions to...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$165K - $220K *

Pioneer innovative solutions by collaborating with defense clients to operationalize real-time intelligence. Design and deploy data pipelines and applications on Palantir Foundry, ensuring mission-cri...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing software quality through innovative test automation. Collaborate with cross-functional teams to design, develop, and execute automated testing solutions that...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$70K - $110K *

Elevate your career as a CyberArk SME/DevOps Engineer, implementing secure solutions for federal modernization. Leverage your expertise in privileged access management to drive best practices and enha...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $130K *

Advance your career by overseeing the reliability and support of network systems. Play a key role in designing and maintaining software automation, ensuring operational stability across platforms and...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $230K *

Deliver advanced electrical engineering solutions for hyperscale data centers. Lead design teams, oversee project execution, and ensure compliance with industry standards while fostering client relati...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Technical Services

$90K - $125K *

Lead the charge in diverse control system projects, overseeing tasks and teams while ensuring successful project completion. Collaborate with stakeholders and provide engineering support, driving qual...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$218K - $256K *

Shape the future of customer engagement by leading the design and delivery of innovative ML systems. Collaborate with cross-functional teams to enhance automation, safety, and customer experience thro...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Accelerate progress at the forefront of technology by owning deployments, solving complex problems, and driving strategic initiatives for major clients. Collaborate closely with engineering and custom...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$131K - $205K *

Engage in the design and evaluation of electric power generation projects. Provide technical support and owner’s engineering services, focusing on thermal power systems. Collaborate on project develop...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$120K - $140K *

Drive impactful design solutions for developer tools, collaborating closely with engineers and PMs. Own workflows from discovery to delivery, enhancing user experiences and contributing to a robust de...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by leading a dynamic team in data engineering and AI-ready data enablement. Drive innovation, mentor talent, and collaborate with IT and business teams to create trusted data produ...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $114K *

Transform customer experiences by bridging technical solutions and business outcomes. Collaborate with cross-functional teams to deliver tailored solutions that enhance people operations and culture...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$88K - $105K *

Join a team that's dedicated to delivering high-quality design-build projects. As a Senior Project Engineer, you'll oversee project execution, mentor junior staff, and ensure timely completion from de...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$207K - $218K *

Champion innovative machine learning solutions to enhance service availability, optimize routing, and improve fulfillment efficiency in a complex logistics environment, driving profitability and shopp...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$220K - $275K *

Partner with us to drive AI transformation in customer experience. As a Principal Solutions Engineer, you'll guide clients through the design and implementation of innovative AI solutions, ensuring al...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$136K - $160K *

Advance the software delivery process by managing launches and releases, ensuring accuracy and efficiency through automation and collaboration with cross-functional teams. Design workflows and tools t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Empower cross-functional teams to consolidate payment gateways, leveraging deep USA Payments expertise. Collaborate with stakeholders to analyze requirements, drive migrations, and ensure seamless int...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$82K - $123K *

Transform your career by joining a dynamic team focused on innovative full stack development, integrating AI capabilities, and delivering robust solutions for diverse business needs. Collaborate with...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Empower innovation by designing intelligent AI agents and automation solutions. Collaborate with architects and stakeholders to implement cutting-edge Generative AI technologies for enterprise applica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$132K - $143K *

Shape the future of digital solutions by developing innovative M365 and Power Platform applications. Collaborate with a dynamic team to enhance enterprise collaboration, automate processes, and levera...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$62K - $99K *

Lead project teams in efficiently onboarding clients to software, focusing on ACV recognition while mentoring junior staff and ensuring project success through strategic planning and cross-functional...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.