Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Strategic Solutions Architect
$175K - $205K *
Transform the future of client technology by leading architectural strategies and integrations in life insurance and annuity environments, ensuring alignment with enterprise goals and delivering scala...
Reposted today
Senior Mechanical Engineer | Kansas City, MO
$95K - $115K *
Transform mechanical design by leading HVAC, plumbing, and fire protection projects. Collaborate with clients and teams to deliver innovative, energy-efficient solutions while mentoring staff and ensu...
1 week ago
$137K - $245K *
Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...
1 week ago
$137K - $245K *
Lead the charge in driving strategic initiatives and product innovation within the Telematics Business Unit, enhancing core offerings and exploring new market opportunities through hands-on collaborat...
2 weeks ago
$100K - $110K *
Unlock potential by leading complex projects within a dynamic ePMO, driving cross-functional alignment, and ensuring timely execution while communicating effectively with senior leadership to foster t...
Yesterday
Sr Engineer, Site Reliability Engineer
$111K - $134K *
Transform critical platforms by leading Site Reliability Engineering initiatives. Collaborate with cross-functional teams to enhance system reliability, scalability, and performance through automation...
3 weeks ago
Forward Deployed Engineer - US Remote
$157K - $185K *
Join a team that's building cutting-edge data infrastructure for enterprises. As a Forward Deployed Engineer, you'll create production-quality agents and integrations directly within customer environm...
2 weeks ago
Senior Manager, Recruiting, Claude Corps
$110K - $150K *
Empower early talent recruitment by leading a dynamic screener team. Drive application reviews, maintain selection standards, and ensure timely candidate decisions while collaborating closely with lea...
Today
$184K - $356K *
Unlock potential by developing innovative AI solutions and enhancing infrastructure capabilities. Collaborate with strategic partners to deliver hands-on technical support, ensuring optimal performanc...
5 days ago
Senior Backend Engineer - Databases Tempo | US | Remote
$154K - $185K *
Lead the evolution of Tempo, enhancing observability products through innovative solutions, operational excellence, and high-performance APIs while mentoring engineers and collaborating across teams t...
2 weeks ago
Senior Site Reliability Engineer
$158K - $234K *
Develop and enhance infrastructure and tools to empower developers in delivering scalable, secure, and reliable software. Collaborate across teams to improve system reliability, automate processes, an...
3 weeks ago
Sr. Staff Applied AI Engineer, GTM
$180K - $225K *
Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...
1 week ago
Senior Partner Success Implementation Engineer
$120K - $145K *
Drive partner success by providing expert technical guidance, leading complex implementations, and mentoring junior engineers. Collaborate cross-functionally to enhance product adoption and ensure opt...
1 week ago
$150K - $240K *
Develop innovative PCB layouts and improve product designs by collaborating with cross-functional teams. Ensure high quality and compliance throughout the engineering and manufacturing process, while...
Reposted 1 week ago
Technical Services Engineer - Federal
$125K - $150K *
Join a team that's dedicated to providing exceptional post-sales technical support for federal clients. You'll troubleshoot complex systems, collaborate with engineering teams, and ensure seamless ope...
2 weeks ago
Software Engineer - Data Platform (R37)
$105K - $202K *
Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...
Reposted today
DevOps / Platform Engineer - TS/SCI
$97K - $162K *
Elevate your career by engineering CI/CD platforms that ensure secure, reliable software delivery. Collaborate on modern developer tooling and automation, utilizing cutting-edge technologies to suppor...
Reposted today
$164K - $222K *
Lead the charge in crafting advanced game engine systems, ensuring optimal performance and player experience while collaborating with diverse teams to enhance gameplay and develop innovative solutions...
Reposted 2 weeks ago
Senior Developer Marketing Manager, Lifecycle & Growth
$133K - $186K *
Optimize developer engagement by managing the user journey from first touch to activation. Collaborate with teams to enhance the Developer Hub and drive measurable growth through effective lifecycle m...
1 week ago
Senior Product Manager, AI Evaluation & Quality| Level 18| US: Remote
$150K - $159K *
Analyze and build evaluation frameworks for AI agents, ensuring quality and performance meet client and business standards. Collaborate with cross-functional teams to establish testing methodologies a...
6 days ago
Senior Product Designer, Developer Foundations
$180K - $212K *
Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...
2 weeks ago
Senior Partner Manager, Data & AI Security
$175K - $326K *
Grow your career with a strategic role driving Data & AI Security channel sales. Collaborate with partners to develop scalable practices, enhance revenue, and shape go-to-market strategies while engag...
1 week ago
Senior Business Systems Analyst
$107K - $180K *
Lead the resolution of complex integration issues, collaborating with cross-functional teams to enhance reliability and support. Develop documentation and tools that empower partners and improve opera...
2 weeks ago
Senior Director, Software Engineering
$290K - $436K *
Elevate our mobile engineering organization by leading teams, driving modernization, and ensuring app performance and quality. Collaborate with cross-functional partners to innovate and mentor future...
4 days ago
Senior Developer- Python Full Stack
$120K - $145K *
Drive the design and implementation of innovative pricing tools, enhancing market readiness and efficiency. Collaborate across teams to establish technical standards and mentor junior developers while...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.