Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$175K - $205K *

Transform the future of client technology by leading architectural strategies and integrations in life insurance and annuity environments, ensuring alignment with enterprise goals and delivering scala...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Transform mechanical design by leading HVAC, plumbing, and fire protection projects. Collaborate with clients and teams to deliver innovative, energy-efficient solutions while mentoring staff and ensu...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$137K - $245K *

Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$137K - $245K *

Lead the charge in driving strategic initiatives and product innovation within the Telematics Business Unit, enhancing core offerings and exploring new market opportunities through hands-on collaborat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $110K *

Unlock potential by leading complex projects within a dynamic ePMO, driving cross-functional alignment, and ensuring timely execution while communicating effectively with senior leadership to foster t...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$111K - $134K *

Transform critical platforms by leading Site Reliability Engineering initiatives. Collaborate with cross-functional teams to enhance system reliability, scalability, and performance through automation...

3 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$157K - $185K *

Join a team that's building cutting-edge data infrastructure for enterprises. As a Forward Deployed Engineer, you'll create production-quality agents and integrations directly within customer environm...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $150K *

Empower early talent recruitment by leading a dynamic screener team. Drive application reviews, maintain selection standards, and ensure timely candidate decisions while collaborating closely with lea...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$184K - $356K *

Unlock potential by developing innovative AI solutions and enhancing infrastructure capabilities. Collaborate with strategic partners to deliver hands-on technical support, ensuring optimal performanc...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$154K - $185K *

Lead the evolution of Tempo, enhancing observability products through innovative solutions, operational excellence, and high-performance APIs while mentoring engineers and collaborating across teams t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$158K - $234K *

Develop and enhance infrastructure and tools to empower developers in delivering scalable, secure, and reliable software. Collaborate across teams to improve system reliability, automate processes, an...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $225K *

Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive partner success by providing expert technical guidance, leading complex implementations, and mentoring junior engineers. Collaborate cross-functionally to enhance product adoption and ensure opt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $240K *

Develop innovative PCB layouts and improve product designs by collaborating with cross-functional teams. Ensure high quality and compliance throughout the engineering and manufacturing process, while...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's dedicated to providing exceptional post-sales technical support for federal clients. You'll troubleshoot complex systems, collaborate with engineering teams, and ensure seamless ope...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $202K *

Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$97K - $162K *

Elevate your career by engineering CI/CD platforms that ensure secure, reliable software delivery. Collaborate on modern developer tooling and automation, utilizing cutting-edge technologies to suppor...

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$164K - $222K *

Lead the charge in crafting advanced game engine systems, ensuring optimal performance and player experience while collaborating with diverse teams to enhance gameplay and develop innovative solutions...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$133K - $186K *

Optimize developer engagement by managing the user journey from first touch to activation. Collaborate with teams to enhance the Developer Hub and drive measurable growth through effective lifecycle m...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $159K *

Analyze and build evaluation frameworks for AI agents, ensuring quality and performance meet client and business standards. Collaborate with cross-functional teams to establish testing methodologies a...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $212K *

Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$175K - $326K *

Grow your career with a strategic role driving Data & AI Security channel sales. Collaborate with partners to develop scalable practices, enhance revenue, and shape go-to-market strategies while engag...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $180K *

Lead the resolution of complex integration issues, collaborating with cross-functional teams to enhance reliability and support. Develop documentation and tools that empower partners and improve opera...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$290K - $436K *

Elevate our mobile engineering organization by leading teams, driving modernization, and ensuring app performance and quality. Collaborate with cross-functional partners to innovate and mentor future...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Drive the design and implementation of innovative pricing tools, enhancing market readiness and efficiency. Collaborate across teams to establish technical standards and mentor junior developers while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.