Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $130K *
Empower innovation by partnering with data science to build and maintain robust ML pipelines. Drive automation and observability in production systems, ensuring reliable match data at scale while coll...
1 week ago
Senior Software Engineer, Biggy Engineering
$187K - $220K *
Unlock potential by designing and building AI-powered solutions to enhance enterprise IT operations, collaborating directly with customers and driving impactful product features across backend and aut...
Reposted 2 days ago
$127K - $171K *
Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...
Reposted 3 weeks ago
$86K - $140K *
Champion payroll excellence by processing and reconciling payroll across multiple regions, collaborating with cross-functional teams to enhance compliance, reporting, and automation for a seamless emp...
5 days ago
Principal Security Software Engineer, PKI and Secrets Management
$201K - $309K *
Elevate security standards by leading the development of innovative software solutions. Collaborate with cross-functional teams to integrate robust security measures, ensuring the integrity of applica...
5 days ago
Senior Sales Engineer, Data Products
$125K - $160K *
Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...
1 week ago
Senior Sales Solution Engineer
$125K - $138K *
Elevate customer experience by leading technical engagement during pre-sales. Utilize deep knowledge to craft solutions, mentor peers, and ensure seamless transitions, while remaining adaptable in a f...
Reposted 2 weeks ago
Solutions Engineer | PST or EST US | Remote
$182K - $226K *
Unlock potential by joining a dynamic team that drives customer success through technical expertise and innovative solutions, enhancing product engagement and collaboration in a fast-paced startup env...
6 days ago
Senior Global Technology Partner Marketing Manager - EST
$120K - $145K *
Drive the global marketing strategy for a technology partner ecosystem, enhancing customer experiences through seamless integrations. Collaborate with cross-functional teams to create impactful go-to...
2 weeks ago
$130K - $219K *
Engage with customers to identify key challenges and drive product innovation. Collaborate across hardware, software, and AI teams to deliver impactful solutions that enhance physical operations and g...
1 week ago
$100K - $120K *
Engage in innovative engineering solutions by leading design teams, ensuring structural integrity, and enhancing customer relationships while driving continuous improvement and profitability in a coll...
3 weeks ago
Senior Product Marketing Manager | US | Remote
$162K - $194K *
Drive growth as a Senior Product Marketing Manager, shaping messaging and campaigns for Observability products. Collaborate with cross-functional teams to enhance customer engagement and retention thr...
1 week ago
Machine Learning Engineering Manager - Core Ads Ranking
$230K - $322K *
Accelerate progress at shaping foundational models and user understanding while collaborating with cross-functional teams to drive impactful machine learning initiatives and mentor top talent in a dyn...
1 week ago
$180K - $200K *
Elevate healthcare technology by owning mobile and web apps that enhance clinician workflows. Drive product direction, prioritize initiatives, and ensure patient safety while leveraging AI to improve...
1 week ago
$150K - $230K *
Transform customer experiences by leading technical discovery and implementation for federal clients. Collaborate across teams to deliver cutting-edge autonomous solutions, ensuring successful deploym...
2 weeks ago
Software Engineer, Back-End - Mail (US)
$125K - $150K *
Unlock potential by joining our dynamic team to build robust back-end systems that power AI-driven workflows and enhance user experiences across platforms. Collaborate with engineers to innovate and s...
Reposted today
Sr. Software Engineer - Sensor, macOS (Hybrid)
$140K - $220K *
Champion innovation in macOS development, driving core sensor features for endpoint protection. Collaborate with a dynamic team to enhance security capabilities, ensuring high performance and reliabil...
5 days ago
$133K - $173K *
Shape the future of program management by leading complex, large-scale initiatives. Drive strategic outcomes, manage financial performance, and engage stakeholders while fostering innovation through A...
3 weeks ago
Senior Engineer - Mechanical Design
$95K - $115K *
Drive mechanical design excellence for mission-critical facilities, overseeing project execution and mentoring junior engineers. Collaborate across disciplines to ensure accurate construction document...
Reposted today
$137K - $188K *
Drive innovation in data engineering by leading a dedicated team to develop robust data pipelines, ensuring high-quality data products that empower business decisions and enhance our digital capabilit...
3 days ago
$100K - $130K *
Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...
4 weeks ago
Staff Infrastructure and Platform Engineer
$112K - $165K *
Build and maintain robust platform capabilities while ensuring reliability and operational excellence. Collaborate with product teams to enhance service delivery and uphold standards, driving continuo...
4 days ago
Senior Data Scientist I, Monetization
$159K - $188K *
Transform audience and measurement products by independently owning the full lifecycle, from problem framing to delivery. Collaborate with cross-functional teams to enhance data-driven advertising sol...
Reposted today
$150K - $180K *
Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...
Reposted today
Senior Product Security Engineer
$120K - $150K *
Contribute to securing products throughout their lifecycle by collaborating with developers, leading design reviews, and performing penetration testing to enhance security measures and compliance post...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.