Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Empower innovation by partnering with data science to build and maintain robust ML pipelines. Drive automation and observability in production systems, ensuring reliable match data at scale while coll...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$187K - $220K *

Unlock potential by designing and building AI-powered solutions to enhance enterprise IT operations, collaborating directly with customers and driving impactful product features across backend and aut...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$127K - $171K *

Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$86K - $140K *

Champion payroll excellence by processing and reconciling payroll across multiple regions, collaborating with cross-functional teams to enhance compliance, reporting, and automation for a seamless emp...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$201K - $309K *

Elevate security standards by leading the development of innovative software solutions. Collaborate with cross-functional teams to integrate robust security measures, ensuring the integrity of applica...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $160K *

Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $138K *

Elevate customer experience by leading technical engagement during pre-sales. Utilize deep knowledge to craft solutions, mentor peers, and ensure seamless transitions, while remaining adaptable in a f...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$182K - $226K *

Unlock potential by joining a dynamic team that drives customer success through technical expertise and innovative solutions, enhancing product engagement and collaboration in a fast-paced startup env...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive the global marketing strategy for a technology partner ecosystem, enhancing customer experiences through seamless integrations. Collaborate with cross-functional teams to create impactful go-to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$130K - $219K *

Engage with customers to identify key challenges and drive product innovation. Collaborate across hardware, software, and AI teams to deliver impactful solutions that enhance physical operations and g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Engage in innovative engineering solutions by leading design teams, ensuring structural integrity, and enhancing customer relationships while driving continuous improvement and profitability in a coll...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$162K - $194K *

Drive growth as a Senior Product Marketing Manager, shaping messaging and campaigns for Observability products. Collaborate with cross-functional teams to enhance customer engagement and retention thr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$230K - $322K *

Accelerate progress at shaping foundational models and user understanding while collaborating with cross-functional teams to drive impactful machine learning initiatives and mentor top talent in a dyn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$180K - $200K *

Elevate healthcare technology by owning mobile and web apps that enhance clinician workflows. Drive product direction, prioritize initiatives, and ensure patient safety while leveraging AI to improve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Transform customer experiences by leading technical discovery and implementation for federal clients. Collaborate across teams to deliver cutting-edge autonomous solutions, ensuring successful deploym...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$125K - $150K *

Unlock potential by joining our dynamic team to build robust back-end systems that power AI-driven workflows and enhance user experiences across platforms. Collaborate with engineers to innovate and s...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$140K - $220K *

Champion innovation in macOS development, driving core sensor features for endpoint protection. Collaborate with a dynamic team to enhance security capabilities, ensuring high performance and reliabil...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$133K - $173K *

Shape the future of program management by leading complex, large-scale initiatives. Drive strategic outcomes, manage financial performance, and engage stakeholders while fostering innovation through A...

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$95K - $115K *

Drive mechanical design excellence for mission-critical facilities, overseeing project execution and mentoring junior engineers. Collaborate across disciplines to ensure accurate construction document...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$137K - $188K *

Drive innovation in data engineering by leading a dedicated team to develop robust data pipelines, ensuring high-quality data products that empower business decisions and enhance our digital capabilit...

3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $130K *

Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$112K - $165K *

Build and maintain robust platform capabilities while ensuring reliability and operational excellence. Collaborate with product teams to enhance service delivery and uphold standards, driving continuo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$159K - $188K *

Transform audience and measurement products by independently owning the full lifecycle, from problem framing to delivery. Collaborate with cross-functional teams to enhance data-driven advertising sol...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Contribute to securing products throughout their lifecycle by collaborating with developers, leading design reviews, and performing penetration testing to enhance security measures and compliance post...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.