Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$88K - $105K *

Unlock potential by joining a dynamic team focused on developing innovative software solutions. Collaborate across departments to enhance processes and deliver impactful results for internal teams and...

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$125K - $145K *

Drive product strategy and modernization for merchant onboarding solutions, collaborating with cross-functional teams to enhance risk management capabilities and ensure market-leading standards in a d...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $162K *

Lead the charge in delivering exceptional technical support and project leadership for Digital CMU solutions. Collaborate with teams to ensure successful implementations, optimize system performance...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$142K - $196K *

Shape the future of lending as a Senior Software Engineer, leading frontend and full-stack projects. Collaborate with cross-functional teams to enhance borrower experiences using React and TypeScript...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$170K - $272K *

Advance your career by leading the development of scalable ML systems that drive impactful business outcomes through data science innovation and collaboration with cross-functional teams...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$128K - $214K *

Champion user research strategies that shape digital experiences by turning data into actionable insights, collaborating across teams to enhance user engagement and optimize web performance globally...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$117K - $164K *

Transform your career by leading Identity and Access Management initiatives, enhancing security protocols, and driving automation in a dynamic IT environment. Collaborate with cross-functional teams t...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $185K *

Lead high-performing software engineering teams to modernize customer-facing applications, enhance operational efficiency, and drive AI-enabled practices, ensuring alignment with business objectives a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$150K - $200K *

Champion the resolution of complex technical issues for clients, leveraging expertise in Linux, networking, and cloud environments. Collaborate with teams to enhance service delivery and operational c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $137K *

Unlock your potential as you drive secure automation for cloud migrations, developing infrastructure as code and CI/CD pipelines. Collaborate with teams to enhance processes and ensure compliance whil...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by leading the RPA strategy and AI integration across banking platforms. Drive automation architecture, development, and deployment while mentoring teams and ensuring compliance in a...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $170K *

Engineer robust pipelines to transform raw conversation data into structured customer memory, ensuring accuracy and efficiency in retrieval systems while collaborating with cross-functional teams to e...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Partner with us to drive customer success by implementing and expanding Teleport solutions. Leverage your expertise to enhance adoption, troubleshoot issues, and deliver tailored training, ensuring cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$60K - $142K *

Lead the design and development of innovative automation solutions across multiple platforms, enhancing client experiences and operational efficiency while driving technical direction and agile practi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$115K - $145K *

Lead security initiatives by collaborating with cross-functional teams to embed security in the software development lifecycle, ensuring robust protection for high-risk product areas while driving ado...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $235K *

Transform AI/ML systems by leading end-to-end development of innovative solutions. Tackle complex challenges in medical synthesis and help define and deploy advanced features that enhance user experie...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Take ownership of complex technical issues, driving resolution and enhancing customer experience through deep problem-solving and collaboration with cross-functional teams...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower innovation by partnering with data science to build and maintain robust ML pipelines. Drive automation and observability in production systems, ensuring reliable match data at scale while coll...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$125K - $138K *

Elevate customer experience by leading technical engagement during pre-sales. Utilize deep knowledge to craft solutions, mentor peers, and ensure seamless transitions, while remaining adaptable in a f...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$201K - $309K *

Elevate security standards by leading the development of innovative software solutions. Collaborate with cross-functional teams to integrate robust security measures, ensuring the integrity of applica...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$190K - $304K *

Champion product growth by guiding strategy and development from MVP to scale. Collaborate with cross-functional teams to deliver clear, impactful solutions, while continuously refining based on custo...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$187K - $220K *

Unlock potential by designing and building AI-powered solutions to enhance enterprise IT operations, collaborating directly with customers and driving impactful product features across backend and aut...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$86K - $140K *

Champion payroll excellence by processing and reconciling payroll across multiple regions, collaborating with cross-functional teams to enhance compliance, reporting, and automation for a seamless emp...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$127K - $171K *

Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$182K - $226K *

Unlock potential by joining a dynamic team that drives customer success through technical expertise and innovative solutions, enhancing product engagement and collaboration in a fast-paced startup env...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.