Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$199K - $276K *

Drive enhancements to our unsecured underwriting models through rigorous research and experimentation. Collaborate with engineering teams to translate findings into scalable solutions that improve cre...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$171K - $285K *

Transform your career by leading a high-performing engineering team to deliver innovative digital solutions. Collaborate across departments to drive technology strategy and modernize capabilities, ens...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$115K - $158K *

Join a dynamic team to develop cutting-edge AI for audio experiences. You'll design, train, and optimize machine learning models, collaborating with engineers to enhance product capabilities while pus...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$105K - $163K *

Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $130K *

Lead the charge in advancing automation and controls technologies across global operations, ensuring compliance and operational readiness while collaborating with international teams to implement inno...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$141K - $186K *

Transform aviation security by leading multidisciplinary teams, managing client relationships, and ensuring project success in airport technology systems. Leverage 8-10 years of experience to enhance...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$141K - $186K *

Elevate your career by leading technology and security engineering for major aviation projects. Collaborate with clients and multidisciplinary teams to ensure successful project delivery while enhanci...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$130K - $150K *

Join a dynamic team as a senior technical leader, driving innovative platform solutions and enhancing integration processes. Collaborate across teams to improve user experiences and streamline operati...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $100K *

Champion seamless customer experiences by resolving technical issues and collaborating cross-functionally. Leverage your expertise to enhance product reliability and drive customer satisfaction in a d...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$123K - $159K *

Build core AI platform capabilities that empower teams to develop, run, and scale GenAI applications, collaborating across the tech stack to deliver impactful solutions for millions of users in a fast...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Lead the charge in shaping innovative Network Observability products, driving strategy from concept to launch. Collaborate with cross-functional teams to deliver solutions that empower operators to op...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $187K *

Accelerate progress at client engagement by managing relationships, driving sales strategies, and ensuring delivery excellence. Collaborate with teams to create account plans and optimize performance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining automation in industrial testing. You'll develop robust test frameworks and simulators, ensuring seamless integration and coverage for critical protocols while collaborat...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$154K - $185K *

Join a team that's enhancing Grafana's data source plugins, ensuring reliability and seamless integration for users worldwide. Lead development efforts and collaborate to deliver world-class observabi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the architectural vision for scalable Identity Resolution platforms, driving innovation in enterprise applications and data processing. Collaborate with engineering teams to ensure robust, high-p...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$71K - $107K *

Transform manufacturing processes by leading technical initiatives and optimizing systems. Collaborate closely with teams to improve product quality and enhance operational performance through effecti...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$145K - $175K *

Champion the integration of AI-powered API services, ensuring reliability and scalability while bridging traditional systems with modern language models. Drive innovation in backend workflows and coll...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$111K - $144K *

Optimize product strategies and drive development from concept to launch. Collaborate with cross-functional teams to align product vision with business goals, ensuring high-quality outcomes that meet...

Today

  •   5 - 7 years exp.  •   Information Technology

$161K - $242K *

Lead the charge in driving the cardiology portfolio's growth and modernization. Own strategy, adoption, cloud migration, and pricing while collaborating across teams to enhance patient outcomes and op...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$165K - $243K *

Lead the charge in data engineering excellence by mentoring a team, driving pipeline delivery, and translating stakeholder needs into actionable technical plans while ensuring operational accountabili...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$235K - $270K *

Elevate the future of transportation by leading the integration of autonomous driving technology into our robotaxi fleet. Drive cross-functional collaboration, manage risks, and ensure a seamless mark...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$188K - $245K *

Drive innovative UX design strategies in clinical settings, leading a talented team to enhance decision support and care coordination. Collaborate across functions to integrate AI and elevate user exp...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$94K - $130K *

Join a team that's driving security outcomes in DevSecOps Engineering. You'll prioritize the backlog, define features, and collaborate with stakeholders to enhance developer experience while managing...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$120K - $130K *

Join a dynamic team to design and optimize scalable data solutions that enhance healthcare technology platforms. Collaborate with cross-functional teams to ensure data integrity and drive informed dec...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Innovate by developing scalable applications and data pipelines, leveraging Python and cloud platforms. Collaborate with cross-functional teams to modernize enterprise systems and enhance backend serv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.