Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$106K - $159K *

Grow your career with a dynamic team focused on building scalable identity management solutions. Collaborate across IT to solve complex challenges, design innovative software, and enhance user experie...

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$173K - $290K *

Lead product strategy for design systems and accessibility, driving innovation and adoption across teams. Shape integrated roadmaps, enhance product health, and ensure alignment with evolving AI-nativ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $145K *

Lead strategic product initiatives in advanced surgical technologies, driving development and commercialization efforts. Collaborate with cross-functional teams to enhance orthopedic outcomes and proc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$230K - $322K *

Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Media

$100K - $120K *

Join a dynamic team as a System Engineer, specializing in Linux systems and automation. You'll lead the design and maintenance of provisioning workflows, configuration management, and Linux networking...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $180K *

Innovate with us as you lead technical delivery for enterprise data integration and migration projects, focusing on Higher Education and Salesforce ecosystems. Drive solution architecture, manage team...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$140K - $160K *

Join a dynamic team as you architect secure CI/CD pipelines, manage Kubernetes clusters, and implement security automation in AWS. Collaborate across teams to enhance operational efficiency while embe...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $210K *

Drive complex enterprise SaaS projects with a focus on alignment, execution, and risk management while engaging with stakeholders across all levels to ensure successful implementations and foster cont...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$185K - $344K *

Lead a dynamic team in developing cutting-edge machine learning infrastructure, driving AI initiatives that impact millions. Foster collaboration and continuous improvement while mentoring talent in a...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $120K *

Drive innovative process design by leading teams, mentoring talent, and ensuring compliance with industry standards. Collaborate with clients to refine deliverables and enhance workflows, fostering co...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$152K - $190K *

Unlock potential by leading the development and support of Dynamics 365 and Power Apps solutions, ensuring compliance and enhancing user experience through effective sprint-based methodologies and int...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$164K - $339K *

Drive the product strategy for GenAI safety, ensuring AI systems are safe, fair, and trustworthy. Collaborate with cross-functional teams to identify risks and translate policies into product requirem...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$102K - $148K *

Lead the charge in managing Mainframe Systems Programming teams, ensuring project alignment and team development. Drive performance through mentoring, risk management, and effective communication whil...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in developing custom Duck Creek solutions, collaborating with clients and teams to deliver scalable, technical solutions while mentoring junior developers and driving project success...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$195K - $208K *

Reimagine user experiences by leading design for core product features, ensuring seamless integration and customer delight. Collaborate across teams to enhance engagement and trust, shaping the future...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$105K - $168K *

Lead the transformation of delivery management by owning the product roadmap, enhancing dispatch efficiency, and leveraging AI to streamline operations, ensuring timely and accurate service for restau...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $190K *

Unlock potential by managing complex technical programs that drive innovation and operational excellence. Collaborate with cross-functional teams and clients to ensure successful delivery of large-sca...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $160K *

Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Join us to lead the development of cutting-edge Operational AI solutions, collaborating with Global 2000 engineering teams. Drive technical integrity from architecture to production, ensuring impactfu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $187K *

Transform public sector sales by driving growth strategies, building executive relationships, and leading complex pursuits. Leverage your expertise in IT consulting and digital transformation to close...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Join us to lead security and compliance initiatives within a dynamic platform team. You'll leverage your expertise to enhance production infrastructure, ensuring robust protection and reliability for...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$150K - $180K *

Transform the future of intelligent compiler technologies by designing and optimizing advanced systems that enhance developer productivity and system performance across software and hardware boundarie...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $150K *

Lead the charge in designing and implementing HR Service Delivery solutions, integrating Microsoft 365 with ServiceNow. Optimize employee experiences through automated workflows and seamless connectio...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.