Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Developer - Go Language (US Citizenship REQUIRED)
$106K - $159K *
Grow your career with a dynamic team focused on building scalable identity management solutions. Collaborate across IT to solve complex challenges, design innovative software, and enhance user experie...
4 weeks ago
Senior Program Manager - Data Center Construction
$110K - $130K *
Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...
Yesterday
Principal Product Manager, Design Systems & Accessibility
$173K - $290K *
Lead product strategy for design systems and accessibility, driving innovation and adoption across teams. Shape integrated roadmaps, enhance product health, and ensure alignment with evolving AI-nativ...
3 weeks ago
Senior Global Product Manager, Enabling Technologies
$120K - $145K *
Lead strategic product initiatives in advanced surgical technologies, driving development and commercialization efforts. Collaborate with cross-functional teams to enhance orthopedic outcomes and proc...
3 weeks ago
Staff Machine Learning Engineer, Ads Forecasting & Scenarios
$230K - $322K *
Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...
5 days ago
$100K - $120K *
Join a dynamic team as a System Engineer, specializing in Linux systems and automation. You'll lead the design and maintenance of provisioning workflows, configuration management, and Linux networking...
Yesterday
$140K - $180K *
Innovate with us as you lead technical delivery for enterprise data integration and migration projects, focusing on Higher Education and Salesforce ecosystems. Drive solution architecture, manage team...
3 weeks ago
Senior DevSecOps Engineer (Remote)
$140K - $160K *
Join a dynamic team as you architect secure CI/CD pipelines, manage Kubernetes clusters, and implement security automation in AWS. Collaborate across teams to enhance operational efficiency while embe...
1 week ago
$150K - $210K *
Drive complex enterprise SaaS projects with a focus on alignment, execution, and risk management while engaging with stakeholders across all levels to ensure successful implementations and foster cont...
Reposted 3 weeks ago
Manager Machine Learning Engineering
$185K - $344K *
Lead a dynamic team in developing cutting-edge machine learning infrastructure, driving AI initiatives that impact millions. Foster collaboration and continuous improvement while mentoring talent in a...
Reposted 3 days ago
$100K - $120K *
Drive innovative process design by leading teams, mentoring talent, and ensuring compliance with industry standards. Collaborate with clients to refine deliverables and enhance workflows, fostering co...
2 weeks ago
SME Software Developer - REMOTE
$114K - $252K *
Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...
1 week ago
Senior Microsoft Dynamics 365 and Power Apps Developer
$152K - $190K *
Unlock potential by leading the development and support of Dynamics 365 and Power Apps solutions, ensuring compliance and enhancing user experience through effective sprint-based methodologies and int...
1 week ago
Senior Product Manager, Deceptive Content
$164K - $339K *
Drive the product strategy for GenAI safety, ensuring AI systems are safe, fair, and trustworthy. Collaborate with cross-functional teams to identify risks and translate policies into product requirem...
Reposted 2 weeks ago
Manager, Mainframe Systems Programming
$102K - $148K *
Lead the charge in managing Mainframe Systems Programming teams, ensuring project alignment and team development. Drive performance through mentoring, risk management, and effective communication whil...
3 weeks ago
$95K - $115K *
Lead the charge in developing custom Duck Creek solutions, collaborating with clients and teams to deliver scalable, technical solutions while mentoring junior developers and driving project success...
2 weeks ago
Director of Product Design, Engage
$195K - $208K *
Reimagine user experiences by leading design for core product features, ensuring seamless integration and customer delight. Collaborate across teams to enhance engagement and trust, shaping the future...
3 weeks ago
Principal Product Manager, Commercial Lead
$105K - $168K *
Lead the transformation of delivery management by owning the product roadmap, enhancing dispatch efficiency, and leveraging AI to streamline operations, ensuring timely and accurate service for restau...
Reposted 4 days ago
$150K - $190K *
Unlock potential by managing complex technical programs that drive innovation and operational excellence. Collaborate with cross-functional teams and clients to ensure successful delivery of large-sca...
3 weeks ago
Senior Electrical Application Engineer
$125K - $160K *
Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...
3 weeks ago
Senior Director, Forward Deployed Engineer - Operational AI
$175K - $210K *
Join us to lead the development of cutting-edge Operational AI solutions, collaborating with Global 2000 engineering teams. Drive technical integrity from architecture to production, ensuring impactfu...
Yesterday
$100K - $187K *
Transform public sector sales by driving growth strategies, building executive relationships, and leading complex pursuits. Leverage your expertise in IT consulting and digital transformation to close...
2 weeks ago
$130K - $155K *
Join us to lead security and compliance initiatives within a dynamic platform team. You'll leverage your expertise to enhance production infrastructure, ensuring robust protection and reliability for...
6 days ago
Senior Compiler Engineer, Agentic Compiler Systems
$150K - $180K *
Transform the future of intelligent compiler technologies by designing and optimizing advanced systems that enhance developer productivity and system performance across software and hardware boundarie...
Yesterday
ServiceNow Mid-Level Developer
$130K - $150K *
Lead the charge in designing and implementing HR Service Delivery solutions, integrating Microsoft 365 with ServiceNow. Optimize employee experiences through automated workflows and seamless connectio...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.