Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$280K - $300K *

Pioneer innovative AI solutions in workforce management, leading product development from concept to deployment. Collaborate with engineers and executives to create impactful agentic products that enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$216K - $318K *

Drive innovation as you lead engineering teams to build and scale Life360's critical platforms. Ensure reliability and security while fostering a culture of accountability and technical excellence for...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$164K - $240K *

Accelerate progress at the forefront of private cloud architecture by designing, deploying, and optimizing solutions. Leverage your expertise to drive standards, mentor teams, and cultivate robust cli...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $130K *

Drive the design and deployment of secure AI applications in cloud environments, integrating advanced technologies like machine learning and ServiceNow solutions to enhance operational efficiency and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$102K - $170K *

Lead the charge in full-stack development, collaborating on enterprise modernization with Microservices. Deliver high-quality software, mentor engineers, and ensure best practices for cloud technologi...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$107K - $180K *

Drive the strategy and operations of a dynamic contingent workforce program, enhancing governance and service delivery. Collaborate cross-functionally to implement scalable processes and support inter...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Elevate your career by developing innovative solutions within the Infor LN platform. Collaborate with cross-functional teams to enhance payment processing capabilities and create seamless integrations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$104K - $140K *

Help us drive innovation as a Principal Electrical Engineer, specializing in power systems. You will lead design teams, engage with customers, and develop cutting-edge power electronics to meet requir...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$140K - $160K *

Architect robust Azure cloud solutions while ensuring system performance, security, and scalability. This hands-on role requires deep technical expertise, collaboration with cross-functional teams, an...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$127K - $163K *

Empower the design and delivery of scalable data solutions on Google Cloud, leading a team to enhance operational excellence and drive strategic business outcomes through innovative data engineering p...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$93K - $138K *

Join a team that's dedicated to enhancing operational efficiency through innovative software solutions. As a key contributor, you'll develop and maintain applications that streamline processes, ensuri...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$215K - $270K *

Lead the charge in building a high-performing Solutions Engineering team focused on autonomous site security. Drive technical sales, manage customer engagements, and ensure consistent quota attainment...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $154K *

Shape the future of financial crimes compliance by leading complex programs that enhance operational efficiency and regulatory adherence. Collaborate with cross-functional teams to drive strategic ini...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $120K *

Support software design and coding in a collaborative environment, enhancing internal systems and resolving bugs while continuously developing coding skills in a diverse technology landscape...

Reposted today

  •   Less than 5 years exp.  •   Technical Services

$115K - $120K *

Lead the charge in software design and development, enhancing internal systems with innovative coding solutions while collaborating within a dynamic team environment focused on quality and efficiency...

Reposted today

  •   Less than 5 years exp.  •   Technical Services

$114K - $190K *

Build a resilient Site Reliability Engineering practice, leading a global team to enhance cloud platform reliability, scalability, and operational excellence while fostering collaboration and continuo...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $225K *

Drive innovation and strategic leadership in wastewater treatment and reuse projects, guiding multidisciplinary teams to deliver sustainable, cutting-edge engineering solutions while fostering client...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape innovative consumer experiences as a Product Manager, driving strategy, roadmap, and customer insights. Collaborate with marketing and engineering to expand distribution and elevate web and mobi...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate data engineering capabilities by designing robust ETL/ELT workflows, ensuring data quality, and implementing scalable solutions on AWS and Kubernetes. Collaborate with teams to optimize perfor...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$142K - $250K *

Accelerate innovation in autonomous agriculture by leading product strategy, collaborating with engineering and commercial teams, and transforming customer insights into impactful solutions that drive...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$104K - $140K *

Take ownership of engineering projects, ensuring timely and budget-compliant delivery while leading cross-functional teams and liaising with various departments to meet customer specifications...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$122K - $150K *

Support the design and maintenance of a global virtual desktop environment, serving as the SME for troubleshooting and optimizing performance while collaborating across multiple complex production env...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in driving new business acquisition and expanding opportunities across Consumer Goods, Retail, and Travel sectors. Leverage industry expertise to build relationships and position as a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Transform the Teleport Core Product by tackling performance, scalability, and security challenges. Lead a distributed team to design, develop, and implement high-quality solutions while enhancing obse...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.