Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$113K - $178K *

Drive your career with a senior role focused on software development for control room simulators, collaborating with engineers to enhance plant models and ensure high-quality deliverables in a dynamic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$112K - $151K *

Play a key role in the development and integration of cutting-edge systems for aircraft health management. Collaborate with cross-functional teams, manage project budgets, and engage with stakeholders...

Reposted today

  •   5 - 7 years exp.  •   Aerospace & Defense

$112K - $120K *

Optimize client success by leading end-to-end implementations for banks and credit unions, ensuring timely launches and measurable value through strategic guidance and cross-functional collaboration...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's shaping the future of software development by leading projects, mentoring engineers, and architecting innovative solutions that enhance performance and meet business goals in a coll...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock potential by building and scaling a bare metal cloud infrastructure. Collaborate with a skilled team to automate server lifecycles and design efficient systems, shaping the future of our coloca...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$143K - $165K *

Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $120K *

Transform customer experiences by leading complex implementations, aligning stakeholders, and ensuring successful technical deployments that drive meaningful business outcomes across multiple projects...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$250K - $500K *

Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $240K *

Join a dynamic team as you provide technical expertise, drive enterprise opportunities, and architect innovative solutions that meet client needs while showcasing the value of our cutting-edge product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$217K - $303K *

Join a team that's building powerful tools for moderators, enhancing user experience through innovative backend solutions for one of the world's largest platforms. Drive technical strategy and lead en...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Media

$116K - $207K *

Lead and manage mid to large Workday deployments, resolving complex issues while enhancing methodologies. Guide teams, ensure project success, and support executive expectations through effective comm...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$186K - $218K *

Shape the future of financial clarity by delivering core Portfolio experiences. Collaborate with cross-functional teams to transform complex data into user-friendly interfaces, ensuring performance an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's shaping database strategies and standards. In this role, you'll enhance database performance, ensure data integrity, and collaborate with engineering teams to optimize our database...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Champion quality and compliance as you lead critical testing activities, ensuring adherence to standards while collaborating with teams to enhance product performance and customer satisfaction in a dy...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$183K - $220K *

Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in architecting and automating secure CI/CD pipelines and cloud infrastructure, ensuring compliance and resilience while delivering high-quality software through expert DevSecOps pract...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$175K - $200K *

Build innovative interfaces that enhance AI development and observability. You'll design and prototype user experiences that empower AI teams to understand and improve their applications through effec...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Join a team that's redefining onboarding experiences by optimizing customer activation and conversion. You'll lead the charge in creating a seamless journey for new users, ensuring they derive value f...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $155K *

Drive product growth through data analysis and experimentation, collaborating with cross-functional teams to enhance user adoption and engagement. Utilize statistical methods to illuminate user journe...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $190K *

Drive member activation by leading a cross-functional team to optimize outreach, incentives, and messaging strategies. Own the activation roadmap and funnel metrics to enhance engagement and ensure sc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion customer solutions by rapidly prototyping and deploying AI-driven applications. Collaborate with cross-functional teams to enhance product capabilities and drive adoption, ensuring impactful...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$135K - $150K *

Join a team that's engineering innovative cloud solutions, ensuring stability and performance while driving continuous improvement across scalable environments. Your expertise will shape the future of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Empower startups to achieve rapid compliance with Vanta's AI-driven solutions. As a Staff Product Designer, you'll shape the customer experience from onboarding to activation, driving product strategy...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform the engineering landscape by leading a high-performing team, ensuring operational efficiency and technical excellence, while fostering growth, collaboration, and innovative solutions across...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.