Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer 4 (Commercial Nuclear)
$113K - $178K *
Drive your career with a senior role focused on software development for control room simulators, collaborating with engineers to enhance plant models and ensure high-quality deliverables in a dynamic...
2 weeks ago
Experienced Systems Engineer - Product Owner
$112K - $151K *
Play a key role in the development and integration of cutting-edge systems for aircraft health management. Collaborate with cross-functional teams, manage project budgets, and engage with stakeholders...
Reposted today
$112K - $120K *
Optimize client success by leading end-to-end implementations for banks and credit unions, ensuring timely launches and measurable value through strategic guidance and cross-functional collaboration...
3 weeks ago
$120K - $145K *
Join a team that's shaping the future of software development by leading projects, mentoring engineers, and architecting innovative solutions that enhance performance and meet business goals in a coll...
6 days ago
Cloud - Bare Metal Infrastructure Engineer
$125K - $150K *
Unlock potential by building and scaling a bare metal cloud infrastructure. Collaborate with a skilled team to automate server lifecycles and design efficient systems, shaping the future of our coloca...
Today
Sr Manager Product Context Engineering
$143K - $165K *
Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...
Today
$110K - $120K *
Transform customer experiences by leading complex implementations, aligning stakeholders, and ensuring successful technical deployments that drive meaningful business outcomes across multiple projects...
Today
$120K - $145K *
Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...
1 week ago
$250K - $500K *
Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...
1 week ago
$200K - $240K *
Join a dynamic team as you provide technical expertise, drive enterprise opportunities, and architect innovative solutions that meet client needs while showcasing the value of our cutting-edge product...
1 week ago
Staff Backend Engineer, Moderation Enforcement
$217K - $303K *
Join a team that's building powerful tools for moderators, enhancing user experience through innovative backend solutions for one of the world's largest platforms. Drive technical strategy and lead en...
Reposted today
Engagement Manager - LE Diversified Industries
$116K - $207K *
Lead and manage mid to large Workday deployments, resolving complex issues while enhancing methodologies. Guide teams, ensure project success, and support executive expectations through effective comm...
4 weeks ago
Senior Frontend Engineer, Portfolio
$186K - $218K *
Shape the future of financial clarity by delivering core Portfolio experiences. Collaborate with cross-functional teams to transform complex data into user-friendly interfaces, ensuring performance an...
2 weeks ago
$110K - $130K *
Join a team that's shaping database strategies and standards. In this role, you'll enhance database performance, ensure data integrity, and collaborate with engineering teams to optimize our database...
1 week ago
$80K - $95K *
Champion quality and compliance as you lead critical testing activities, ensuring adherence to standards while collaborating with teams to enhance product performance and customer satisfaction in a dy...
Reposted 1 week ago
Principal Technical Marketing Engineer | US | Remote
$183K - $220K *
Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...
1 week ago
$120K - $145K *
Lead the charge in architecting and automating secure CI/CD pipelines and cloud infrastructure, ensuring compliance and resilience while delivering high-quality software through expert DevSecOps pract...
Yesterday
Senior Open Source Design Engineer
$175K - $200K *
Build innovative interfaces that enhance AI development and observability. You'll design and prototype user experiences that empower AI teams to understand and improve their applications through effec...
Reposted 5 days ago
Staff Product Manager, Activation
$135K - $160K *
Join a team that's redefining onboarding experiences by optimizing customer activation and conversion. You'll lead the charge in creating a seamless journey for new users, ensuring they derive value f...
5 days ago
$130K - $155K *
Drive product growth through data analysis and experimentation, collaborating with cross-functional teams to enhance user adoption and engagement. Utilize statistical methods to illuminate user journe...
3 weeks ago
$150K - $190K *
Drive member activation by leading a cross-functional team to optimize outreach, incentives, and messaging strategies. Own the activation roadmap and funnel metrics to enhance engagement and ensure sc...
3 weeks ago
$110K - $130K *
Champion customer solutions by rapidly prototyping and deploying AI-driven applications. Collaborate with cross-functional teams to enhance product capabilities and drive adoption, ensuring impactful...
1 week ago
$135K - $150K *
Join a team that's engineering innovative cloud solutions, ensuring stability and performance while driving continuous improvement across scalable environments. Your expertise will shape the future of...
2 weeks ago
Staff Product Designer, Activation
$135K - $160K *
Empower startups to achieve rapid compliance with Vanta's AI-driven solutions. As a Staff Product Designer, you'll shape the customer experience from onboarding to activation, driving product strategy...
6 days ago
Senior Electrical Engineering Manager
$120K - $145K *
Transform the engineering landscape by leading a high-performing team, ensuring operational efficiency and technical excellence, while fostering growth, collaboration, and innovative solutions across...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.