Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer I (Remote Eligible)
$107K - $147K *
Unlock potential by joining a dynamic team to build scalable applications, tackle distributed systems challenges, and leverage AI for smarter development. Collaborate closely with product management a...
Yesterday
$110K - $130K *
Unlock potential by leading recruitment efforts to attract top engineering talent. Collaborate with hiring managers to develop strategies, assess candidates, and enhance the candidate experience for o...
Reposted 4 days ago
Senior Manager, Partnerships & Channels
$200K - $275K *
Lead the charge in building and scaling a dynamic partner program, driving revenue through strategic alliances and co-selling. Collaborate cross-functionally to establish processes and integrations, e...
1 week ago
Senior Engineering Manager, AI Foundations
$253K - $298K *
Transform AI infrastructure by leading engineering efforts, driving innovation, and ensuring operational excellence across shared services. Collaborate with cross-functional teams to enhance security...
3 weeks ago
Staff Solutions Engineer, MSSP Ecosystem Partner
$224K - $308K *
Unlock potential by leading and scaling our MSSP partner business across North America, combining technical leadership with hands-on architecture engagements to drive strategic growth and adoption of...
2 weeks ago
Senior Strategic Content Manager
$110K - $130K *
Transform your career by leading a high-performing team to create compelling thought leadership content. Drive strategic narratives that align with business priorities and market trends while fosterin...
3 weeks ago
$160K - $180K *
Unlock potential by providing hands-on technical leadership across the full stack. Collaborate with cross-functional teams to design scalable solutions, enhance product experiences, and drive impactfu...
2 weeks ago
Supervisor - Fire/Life Safety Systems Solutions
$70K - $121K *
Lead a dynamic team in the installation and commissioning of fire/life safety systems. Drive project success through technical expertise, mentorship, and effective communication, ensuring customer sat...
1 week ago
$130K - $160K *
Optimize patient-facing and internal tools by delivering seamless integrations and AI-driven features. Take ownership of end-to-end development in a fast-paced telehealth environment focused on men's...
6 days ago
$120K - $150K *
Elevate your career by designing and delivering innovative video solutions across diverse sectors. Collaborate with teams to create scalable architectures that enhance broadcast, streaming, and cloud...
4 weeks ago
Technical Program Manager, Money-as-a-Service
$135K - $160K *
Champion the delivery of large-scale technical programs by leading cross-functional teams, enhancing communication and operational efficiency, and driving strategic decisions to empower users and tack...
Reposted 4 weeks ago
$124K - $156K *
Shape the future of AI Services by owning product strategy and execution. Collaborate with engineering teams to define agentic capabilities, drive tool strategies, and establish AI quality standards t...
3 weeks ago
Senior Solutions Engineer, Enterprise
$250K - $300K *
Join a team that's redefining enterprise solutions! Leverage your expertise in networking and security to drive technical sales, support customer adoption, and influence product development while coll...
3 weeks ago
Senior Engineer (AWS, Azure, Terraform, Kubernetes)
$150K - $175K *
Lead innovative cloud solutions by architecting and managing robust platforms. Collaborate with a dynamic team to tackle complex challenges in AWS and Azure, enhancing your skills while driving impact...
5 days ago
$116K - $157K *
Advance engineering excellence by leading multi-disciplinary teams to deliver projects on time and within budget. Collaborate across departments to ensure compliance with specifications while mentorin...
3 days ago
Senior Gameplay Engineer - Game Modes
$160K - $240K *
Build innovative gameplay systems for an exciting new project, collaborating with a dedicated team to create engaging experiences. Drive technical excellence in C++ and Unreal Engine, ensuring seamles...
4 weeks ago
Senior Product Manager, Integrations & Platform
$175K - $190K *
Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...
2 weeks ago
$110K - $130K *
Drive the execution of complex capital projects, ensuring safety, budget adherence, and regulatory compliance while collaborating with cross-functional teams to enhance operational efficiency and busi...
Reposted 5 days ago
Senior Solutions Engineer, Acquisition | East Coast | Remote
$204K - $254K *
Engage as a key member of a high-growth team, driving technical solutions and customer success through expert presentations, collaboration, and innovative problem-solving in a dynamic startup environm...
4 days ago
$110K - $130K *
Unlock potential by designing and managing cloud systems, collaborating with teams to implement scalable architectures, and ensuring security and performance across platforms. This role requires indep...
2 weeks ago
Senior Manager, Data Engineering
$120K - $145K *
Unlock potential by managing and optimizing data and BI platforms. Collaborate with stakeholders to define architecture, drive project plans, and ensure data quality while leading a team to deliver im...
1 week ago
$130K - $155K *
Empower your career by leading DevOps initiatives, optimizing cloud infrastructure, and driving Agile practices. Collaborate with cross-functional teams to enhance scalability, security, and cost effi...
Today
Senior Cyber Security Engineer
$110K - $130K *
Lead the enhancement of security measures for cloud-based healthcare solutions, focusing on vulnerability management, incident response, and compliance. Collaborate with cross-functional teams to ensu...
2 weeks ago
$95K - $115K *
Drive customer engagement by showcasing innovative security solutions, addressing technical challenges, and collaborating with sales teams to enhance organizational safety and operational integrity in...
6 days ago
$95K - $160K *
Elevate your career by supporting senior leaders in a dynamic tech environment. Manage complex calendars, coordinate travel, and streamline processes to enhance productivity and drive success across g...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.