Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Manager/Senior Manager, Autonomous Enterprise Consulting
$135K - $160K *
Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...
1 week ago
$103K - $138K *
Unlock potential by designing and automating secure, scalable AWS cloud platforms. Collaborate with cross-functional teams to enhance infrastructure reliability and streamline software delivery throug...
3 weeks ago
$83K - $124K *
Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...
1 week ago
Engineering Manager, Federal & Regulated Infrastructure
$215K - $315K *
Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...
2 weeks ago
Senior Professional Services Engineer - PubSec - US Only
$136K - $230K *
Elevate customer success by delivering Professional Services engagements, including installation, migration, and training, while collaborating with project managers to enhance delivery consistency and...
6 days ago
$130K - $145K *
Elevate public health data interoperability by designing and implementing secure, scalable data pipelines. Collaborate with cross-functional teams to modernize legacy systems and ensure compliance, dr...
3 days ago
Staff Product Operations Manager, Platform
$126K - $202K *
Lead impactful initiatives by analyzing data and building tools that drive revenue growth. Collaborate with product teams to identify gaps, streamline processes, and enhance enterprise readiness, ensu...
3 weeks ago
Senior Product Manager, Consumer
$120K - $145K *
Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...
1 week ago
Senior Account Executive - NY/NJ BFSI
$120K - $150K *
Lead strategic sales initiatives by uncovering new opportunities, managing relationships with C-level executives, and executing a comprehensive sales process to achieve quarterly and annual quotas in...
2 weeks ago
Senior Manager Software Engineering
$128K - $252K *
Lead the charge in building and managing high-performing software engineering teams. Drive innovation, optimize processes, and deliver high-quality applications while fostering a culture of excellence...
4 weeks ago
Staff Security Engineer - Calix Cloud
$136K - $265K *
Unlock potential by designing and securing advanced trust architectures across devices and cloud platforms. Collaborate with engineering teams to enhance security measures, conduct threat modeling, an...
Today
$163K - $218K *
Shape the future of information security by maintaining and advancing our ISMS while ensuring ISO 27001 and SOC 2 Type 2 compliance. Drive collaborations across teams to build effective processes and...
Reposted 2 weeks ago
$198K - $205K *
Join a team that's shaping security strategies and solutions to protect digital landscapes. Lead the design and implementation of advanced security controls while mentoring engineers and driving impac...
Today
$135K - $155K *
Lead and mentor a team of data engineers to design, develop, and maintain scalable data pipelines and warehouses, collaborating with stakeholders to deliver key metrics and establish data strategy acr...
Reposted today
Senior Modern Workplace Engineer II
$95K - $115K *
Elevate client experiences by leading Microsoft 365 Modern Work solutions, leveraging deep technical expertise to solve complex business challenges and drive innovation in collaboration systems...
1 week ago
$120K - $145K *
Transform the Web3 landscape by developing innovative dApps and backend services. Collaborate with cross-functional teams to ensure security, scalability, and seamless user experiences in a dynamic, r...
2 weeks ago
Senior Field Engineer, Data Center Design and Engineering
$320K - $405K *
Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...
5 days ago
Senior Quality Assurance Automation Engineer
$110K - $145K *
Empower innovation by designing and implementing automated testing solutions for cloud-based big data analytics. Collaborate with cross-functional teams to enhance product quality and streamline testi...
4 weeks ago
Senior Quality Assurance Automation Engineer
$110K - $145K *
Engineer automated testing solutions for a cloud-based big data platform. Collaborate with cross-functional teams to enhance quality assurance processes and ensure robust application performance in an...
4 weeks ago
Sr. Staff Engineer (Fullstack/Backend)
$150K - $180K *
Lead the charge in architectural innovation and strategic direction, shaping long-term technical landscapes and enabling cross-functional execution at scale while mentoring senior technical leaders an...
4 weeks ago
$140K - $185K *
Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...
Reposted 1 week ago
$185K - $231K *
Join a team that's redefining digital experiences by architecting scalable, resilient systems. Collaborate across teams to enhance performance and reliability while leveraging AI tools to drive innova...
3 weeks ago
Software Engineer II, Monetization Engineering
$123K - $254K *
Architect innovative full-stack solutions that enhance user experiences, collaborating with cross-functional teams to drive product development from ideation to release, while ensuring high-quality co...
4 weeks ago
$105K - $140K *
Contribute to the evolution of cloud platform capabilities by designing and building backend services for orchestration and job execution, ensuring reliable service coordination and operational visibi...
4 weeks ago
Staff Product Security Engineer
$205K - $231K *
Drive your career with impactful security initiatives that enhance product safety and foster responsible AI development. Collaborate across teams to elevate security practices and implement robust gua...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.