Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$144K - $211K *

Lead the charge in managing complex Industrial Controls workstreams, ensuring seamless execution of NPI programs. Collaborate across teams to deliver innovative automation solutions on time and within...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Engage in technical leadership and project management to develop industry standards and reports. Collaborate with working groups to drive best practices and support continuous improvement initiatives...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $220K *

Unlock potential by leading the integration of AI tools with PlanetScale databases. Own the developer experience, ensuring seamless functionality across platforms while creating engaging content to sh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $215K *

Join a dynamic team to manage technology partner relationships, ensuring integration health and driving revenue growth. Collaborate with engineering and commercial teams to resolve issues and optimize...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$138K - $180K *

Lead the delivery of complex DevOps and cloud infrastructure projects, driving collaboration across engineering teams. Manage risks, dependencies, and execution plans to ensure successful project outc...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $160K *

Elevate People Technology by optimizing systems and processes, ensuring data integrity, and enhancing user experiences. Collaborate with cross-functional teams to drive efficiency and support a fast-p...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $190K *

Lead and innovate within UJET's Core Infrastructure team, focusing on cloud-native services. Shape strategies for scalable solutions that empower engineers and optimize the infrastructure for thousand...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Innovate by leveraging your expertise in traditional machine learning to design and optimize solutions for diverse clients. Collaborate with teams or build products, driving impactful results in finan...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in developing innovative machine learning solutions, collaborating with clients to enhance their data-driven decision-making. Utilize your expertise in traditional ML algorithms to del...

Jefferson City, MORemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$198K - $233K *

Empower a team of engineers by architecting a robust AI-driven development pipeline, enhancing workflows across mobile and backend systems, and ensuring reliable, efficient software delivery for milli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$104K - $153K *

Champion innovative AI-driven self-service solutions, enhancing employee experiences through ServiceNow. Collaborate with teams to streamline processes, ensuring high-quality engineering from design t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $195K *

Join a team that's dedicated to reducing food waste by leveraging your technical expertise. You'll tackle complex escalations, drive cross-functional initiatives, and build innovative solutions to enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$177K - $212K *

Develop and deploy advanced ML models for multi-object tracking, ensuring robust performance in autonomous vehicles. Collaborate with cross-functional teams to enhance tracking algorithms and improve...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $138K *

Unlock potential by designing and automating secure, scalable AWS cloud platforms. Collaborate with cross-functional teams to enhance infrastructure reliability and streamline software delivery throug...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Staffing

$83K - $124K *

Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$215K - $315K *

Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$136K - $230K *

Elevate customer success by delivering Professional Services engagements, including installation, migration, and training, while collaborating with project managers to enhance delivery consistency and...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $145K *

Elevate public health data interoperability by designing and implementing secure, scalable data pipelines. Collaborate with cross-functional teams to modernize legacy systems and ensure compliance, dr...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $202K *

Lead impactful initiatives by analyzing data and building tools that drive revenue growth. Collaborate with product teams to identify gaps, streamline processes, and enhance enterprise readiness, ensu...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Lead strategic sales initiatives by uncovering new opportunities, managing relationships with C-level executives, and executing a comprehensive sales process to achieve quarterly and annual quotas in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$128K - $252K *

Lead the charge in building and managing high-performing software engineering teams. Drive innovation, optimize processes, and deliver high-quality applications while fostering a culture of excellence...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$136K - $265K *

Unlock potential by designing and securing advanced trust architectures across devices and cloud platforms. Collaborate with engineering teams to enhance security measures, conduct threat modeling, an...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.