Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$125K - $150K *
Empower teams by designing and building scalable, secure systems that enhance performance and reliability. Collaborate across disciplines to innovate with AI while maintaining a security-first approac...
5 days ago
Senior Professional Services DevOps Engineer
$150K - $180K *
Join a team that's shaping the future of DevOps by designing and implementing CI/CD pipelines with cutting-edge technologies. Collaborate with customers and cross-functional teams to enhance their Dev...
5 days ago
Experienced QA Engineer with Hands-on Automation and AI Skills
$105K - $207K *
Lead the charge in quality assurance as you drive innovative testing solutions, ensuring excellence in custom technology implementations while collaborating with clients and cross-functional teams to...
Yesterday
Experienced QA Engineer with Hands-on Automation and AI Skills
$105K - $207K *
Elevate client success by leading innovative testing solutions in AI & Engineering. Collaborate with top professionals to enhance technology platforms, ensuring quality assurance and driving impactful...
Yesterday
$125K - $150K *
Join a team that's driving growth and innovation in the industry. You'll own P&L, lead strategic initiatives, and foster key customer relationships while managing a dedicated team to achieve ambitious...
5 days ago
$160K - $170K *
Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...
Reposted 5 days ago
$170K - $240K *
Engage in a high-impact role to design and build consumer-centric web applications. Collaborate across teams to enhance performance, mentor engineers, and drive technical decisions that scale innovati...
Reposted today
$120K - $145K *
Take ownership of automating workflows across teams by building AI agents using Claude and Microsoft Copilot. Collaborate with various departments to identify automation opportunities, ensuring securi...
3 weeks ago
$126K - $137K *
Engineer and enhance DevOps practices while managing network infrastructure, automating software delivery, and ensuring security and reliability across environments to improve operational efficiency a...
3 weeks ago
$135K - $160K *
Join a team that's driving innovation by leveraging your technical expertise to lead and mentor engineers, enhance product performance, and deliver high-quality, cloud-native solutions across diverse...
Reposted today
Platform Engineer (ServiceNow)
$110K - $130K *
Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...
Reposted 1 week ago
Senior Director, Site Reliability Engineering
$175K - $250K *
Lead the charge in enhancing the reliability and scalability of a global multi-tenant platform. Drive SRE strategy, foster collaboration across teams, and ensure operational excellence while developin...
5 days ago
$93K - $155K *
Champion innovative product strategies that enhance the athlete journey, leading cross-functional teams to deliver impactful solutions in the club soccer market while optimizing operational efficienci...
Reposted today
Staff Fullstack Engineer (TypeScript)
$190K - $240K *
Deliver high-quality fullstack web solutions, owning major product features from design to launch while collaborating with cross-functional teams to enhance platform reliability and performance...
Today
$185K - $260K *
Join Reddit's Ads team as a Machine Learning Engineer, where you will design, build, and deploy machine learning models to enhance ad ranking, bidding, and optimization. This hands-on role involves ta...
Reposted 2 weeks ago
Director, Analytics Engineering
$139K - $285K *
Drive the analytics engineering team to create AI-ready data solutions, ensuring trusted access to data across the organization. Lead strategic initiatives, build self-service capabilities, and foster...
2 weeks ago
Senior Site Reliability Engineer - Cloud & AI Platforms
$120K - $145K *
Join a dynamic team to enhance the reliability and performance of enterprise AI and Sitecore platforms on VMware Cloud. Collaborate with cross-functional teams to deliver secure, scalable solutions th...
1 week ago
$116K - $135K *
Lead the charge in enhancing product security for critical defense systems, ensuring compliance with government regulations while managing risks and implementing robust cybersecurity measures througho...
Yesterday
$165K - $190K *
Optimize cloud infrastructure and automate processes as a DevOps Engineer. Collaborate with cross-functional teams to enhance system reliability, scalability, and security while driving developer effi...
Today
Lead Data Engineer, AI & Modernization
$87K - $293K *
Champion data engineering excellence by leading migration engagements, developing pipelines and data products for AI systems, and applying innovative evidence-extraction techniques to ensure data inte...
1 week ago
$140K - $150K *
Lead the charge in ensuring top-notch quality across health tech products. Oversee QA execution, mentor junior testers, and collaborate with cross-functional teams to deliver high-quality software tha...
3 days ago
Lead AWS IAM Security Engineer
$135K - $160K *
Elevate cybersecurity by designing and implementing robust security protocols, ensuring compliance across cloud infrastructure while managing IAM, PKI, and secrets management to protect fintech worklo...
Reposted 4 weeks ago
Staff Solutions Architect, AI Subject Matter Expert
$166K - $279K *
Collaborate with cross-functional teams to drive technical success in prioritized opportunities, leveraging deep expertise in a specific product group to influence customer decisions and enhance Solut...
2 weeks ago
$150K - $180K *
Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...
5 days ago
Data Platform Engineer, Senior
$77K - $176K *
Empower your career as a senior platform engineer, leveraging cloud technologies to enhance data environments. Collaborate with cross-functional teams to drive strategy, design, and implementation of...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.