Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$125K - $150K *

Empower teams by designing and building scalable, secure systems that enhance performance and reliability. Collaborate across disciplines to innovate with AI while maintaining a security-first approac...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$150K - $180K *

Join a team that's shaping the future of DevOps by designing and implementing CI/CD pipelines with cutting-edge technologies. Collaborate with customers and cross-functional teams to enhance their Dev...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $207K *

Lead the charge in quality assurance as you drive innovative testing solutions, ensuring excellence in custom technology implementations while collaborating with clients and cross-functional teams to...

Yesterday

  •   5 - 7 years exp.  •   Business Services

$105K - $207K *

Elevate client success by leading innovative testing solutions in AI & Engineering. Collaborate with top professionals to enhance technology platforms, ensuring quality assurance and driving impactful...

Yesterday

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Join a team that's driving growth and innovation in the industry. You'll own P&L, lead strategic initiatives, and foster key customer relationships while managing a dedicated team to achieve ambitious...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $170K *

Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$170K - $240K *

Engage in a high-impact role to design and build consumer-centric web applications. Collaborate across teams to enhance performance, mentor engineers, and drive technical decisions that scale innovati...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Take ownership of automating workflows across teams by building AI agents using Claude and Microsoft Copilot. Collaborate with various departments to identify automation opportunities, ensuring securi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $137K *

Engineer and enhance DevOps practices while managing network infrastructure, automating software delivery, and ensuring security and reliability across environments to improve operational efficiency a...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Join a team that's driving innovation by leveraging your technical expertise to lead and mentor engineers, enhance product performance, and deliver high-quality, cloud-native solutions across diverse...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Media

$110K - $130K *

Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $250K *

Lead the charge in enhancing the reliability and scalability of a global multi-tenant platform. Drive SRE strategy, foster collaboration across teams, and ensure operational excellence while developin...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$93K - $155K *

Champion innovative product strategies that enhance the athlete journey, leading cross-functional teams to deliver impactful solutions in the club soccer market while optimizing operational efficienci...

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$190K - $240K *

Deliver high-quality fullstack web solutions, owning major product features from design to launch while collaborating with cross-functional teams to enhance platform reliability and performance...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $260K *

Join Reddit's Ads team as a Machine Learning Engineer, where you will design, build, and deploy machine learning models to enhance ad ranking, bidding, and optimization. This hands-on role involves ta...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Media

$139K - $285K *

Drive the analytics engineering team to create AI-ready data solutions, ensuring trusted access to data across the organization. Lead strategic initiatives, build self-service capabilities, and foster...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Join a dynamic team to enhance the reliability and performance of enterprise AI and Sitecore platforms on VMware Cloud. Collaborate with cross-functional teams to deliver secure, scalable solutions th...

1 week ago

  •   15+ years exp.  •   Information Technology

$116K - $135K *

Lead the charge in enhancing product security for critical defense systems, ensuring compliance with government regulations while managing risks and implementing robust cybersecurity measures througho...

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$165K - $190K *

Optimize cloud infrastructure and automate processes as a DevOps Engineer. Collaborate with cross-functional teams to enhance system reliability, scalability, and security while driving developer effi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$87K - $293K *

Champion data engineering excellence by leading migration engagements, developing pipelines and data products for AI systems, and applying innovative evidence-extraction techniques to ensure data inte...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$140K - $150K *

Lead the charge in ensuring top-notch quality across health tech products. Oversee QA execution, mentor junior testers, and collaborate with cross-functional teams to deliver high-quality software tha...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Elevate cybersecurity by designing and implementing robust security protocols, ensuring compliance across cloud infrastructure while managing IAM, PKI, and secrets management to protect fintech worklo...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$166K - $279K *

Collaborate with cross-functional teams to drive technical success in prioritized opportunities, leveraging deep expertise in a specific product group to influence customer decisions and enhance Solut...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$77K - $176K *

Empower your career as a senior platform engineer, leveraging cloud technologies to enhance data environments. Collaborate with cross-functional teams to drive strategy, design, and implementation of...

5 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.