Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$115K - $162K *

Develop and optimize backend features for a Rust-based graph data service, enhancing reliability and scalability while collaborating across teams to deliver impactful solutions for GitLab's platform...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $125K *

Optimize game development by enhancing build systems and automating infrastructure. Collaborate with teams to ensure reliable deployments across multiple platforms, driving efficiency and innovation i...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $130K *

Accelerate your career by managing a portfolio of mid-market accounts, ensuring customer success through strategic engagement, relationship building, and AI-driven insights. Drive measurable outcomes...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$103K - $185K *

Join a team that's focused on hands-on technical delivery while mentoring and developing team capabilities. Lead solution implementation, troubleshoot issues, and establish best practices to ensure hi...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$55K - $151K *

Lead innovative software development initiatives, leveraging AI and coding expertise to design, implement, and maintain applications that drive digital transformation and enhance business operations w...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Engineer critical electrical and mechanical systems for data centers, leading field support, troubleshooting, and reliability improvements while developing operational standards and mentoring teams to...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$97K - $162K *

Elevate your career by building innovative backend services that leverage cutting-edge GIS technologies. Collaborate with a passionate team to create impactful solutions for Defense and Intel clients...

Today

  •   Less than 5 years exp.  •   Information Technology

$68K - $189K *

Join a dynamic team as a Digital Senior Developer, driving innovative solutions through full-stack development, cloud architecture, and Agile practices. Collaborate with stakeholders and mentor junior...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Deliver innovative routing solutions for enterprise-scale contact centers. Design and build a robust routing engine that intelligently distributes interactions across various channels, ensuring high a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$165K - $225K *

Unlock your potential by designing and operating robust Kubernetes infrastructure. Collaborate with cross-functional teams to ensure high-performance, reliable systems that support enterprise-scale AI...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$155K - $180K *

Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Reimagine payroll processes by building and managing US and international payroll systems. Own compliance, tax filings, and month-end close while collaborating with teams to ensure accuracy and effici...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Elevate the technical architecture vision and execution across a product portfolio, driving the transition to a scalable, cloud-native SaaS environment while integrating AI, data, and security. Collab...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Business Services

$99K - $232K *

Manage and lead teams to develop data solutions using advanced technologies, transforming insights into actionable strategies. Foster client relationships and drive innovation while mentoring team mem...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$98K - $163K *

Shape your career by providing Tier III IT Systems support across enterprise technologies. Collaborate on projects, resolve complex challenges, and mentor junior engineers while ensuring operational e...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$155K - $200K *

Elevate product management by driving vision, strategy, and execution across digital solutions in clinical development. Collaborate with cross-functional teams to enhance user experience and operation...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a dynamic team to drive product strategy and execution for public safety software. Collaborate across functions to deliver mission-critical solutions that enhance community safety and support eme...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$168K - $238K *

Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$180K - $220K *

Drive the strategy and roadmap for enterprise-scale Computer Vision solutions, collaborating with internal teams to define requirements and ensure successful adoption of AI models across product portf...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$135K - $160K *

Lead the evolution of our GTM Systems Architecture, enhancing Salesforce and its tech stack for AI-native workflows. Collaborate with cross-functional teams to build a trusted data foundation and driv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $191K *

Lead product strategy and execution by driving cross-functional teams to deliver high-quality solutions. Own the product lifecycle, prioritize impactful features, and leverage customer insights to ali...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$135K - $160K *

Accelerate progress at securing cloud environments by designing robust guardrails and automation. Collaborate with engineering teams to embed security into CI/CD pipelines and ensure compliance across...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$105K - $149K *

Transform the future of automation by leading the development of innovative testing strategies and frameworks. Collaborate with teams to ensure high-quality deliverables through effective automation p...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $127K *

Join a team that's redefining revenue operations by owning and enhancing our go-to-market technology stack. You'll collaborate across sales and customer success, driving impactful solutions and integr...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.