Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Data Scientist II, Core & Agentic Automation
$183K - $216K *
Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...
1 week ago
Senior Security Engineer, Proactive Security - Platform
$159K - $235K *
Optimize security infrastructure by designing and implementing robust access management and secrets storage solutions, ensuring seamless integration and operational excellence across engineering teams...
4 days ago
$130K - $155K *
Collaborate to design and develop scalable solutions for modern data platforms, utilizing Python and cloud technology. Drive innovation through AI-assisted tools, while building robust data pipelines...
Reposted 4 weeks ago
$98K - $117K *
Optimize our CI/CD pipelines and infrastructure platforms to enhance software delivery. Collaborate with cross-functional teams to improve reliability and efficiency while developing automation soluti...
Reposted 5 days ago
Manager, Cloud Security Engineering
$125K - $150K *
Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...
5 days ago
$110K - $130K *
Unlock potential by leading the design of innovative applications that empower network teams. Collaborate with cross-functional teams to create user-centric solutions, transforming complex data into i...
2 weeks ago
Sr. Staff Data Migration Engineer
$131K - $164K *
Drive transformative data migration initiatives by leading complex enterprise conversions, aligning cross-functional teams, and enhancing operational strategies to ensure successful onboarding and cus...
1 week ago
Senior Design Program Manager II
$167K - $176K *
Shape the future of design operations by driving program execution, leveraging AI for efficiency, and managing cross-functional partnerships to enhance creative workflows and deliver impactful design...
Reposted 4 days ago
Senior Functional Safety Engineer
$130K - $155K *
Champion the safety design and validation of our autonomous trucking system, ensuring rigorous functional safety standards are met across all engineering and operational teams. Drive impactful safety...
Reposted 3 days ago
$250K - $500K+*
Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...
5 days ago
$150K - $180K *
Drive mobile engineering excellence across diverse product teams, ensuring strategic direction, fostering collaboration, and enhancing delivery. Lead managers, shape architecture, and cultivate a prod...
2 weeks ago
Senior Product Security Engineer
$157K - $184K *
Empower secure software delivery by designing and maintaining robust CI/CD pipelines, enhancing cloud-native product security, and implementing best practices in software supply chain security. Collab...
3 weeks ago
$140K - $165K *
Create innovative solutions as a Software Engineer, shaping a greenfield platform. Collaborate with teams to automate processes, build data infrastructure, and deliver impactful tools while enjoying a...
Yesterday
$90K - $125K *
Join a team that's dedicated to building robust software solutions. Collaborate with cross-functional teams to design, develop, and maintain high-quality applications while ensuring reliability and pe...
1 week ago
Senior Implementation Specialist
$90K - $107K *
Empower enterprises by guiding customers through onboarding and implementation. As a key consultant, you'll drive accountability, promote best practices, and ensure a successful transition to our plat...
Reposted 4 days ago
Engineering Manager (Software)
$110K - $130K *
Bring your expertise to lead software engineering and web development teams, driving product innovation and ensuring compliance with technical and cybersecurity standards while enhancing collaboration...
Reposted 4 weeks ago
Senior Infrastructure & Platform Engineer
$130K - $175K *
Engineer and optimize enterprise platforms for diverse environments, ensuring seamless deployment and support. Collaborate with clients to enhance cybersecurity, compliance, and observability solution...
Reposted 3 days ago
$190K - $200K *
Lead the charge in electrical engineering excellence across multiple campuses, ensuring robust design, validation, and energization of critical infrastructure while integrating onsite generation solut...
3 weeks ago
Principle Machine Learning Engineer
$160K - $200K *
Lead the technical direction for AI agent quality, defining metrics and evaluation systems. Collaborate with cross-functional teams to enhance agent performance and ensure quality in production enviro...
2 weeks ago
$192K - $195K *
Lead the design and implementation of scalable data solutions, driving innovation through technology evaluation and mentoring junior engineers to enhance data processing and delivery quality across mu...
4 days ago
Software Engineer - Technology
$108K - $115K *
Unlock your potential as a full stack engineer, collaborating in an agile team to develop innovative applications and features, while leveraging cutting-edge AI technologies to enhance product offerin...
1 week ago
Quality Automation Engineer (SDET)
$95K - $115K *
Elevate your career by leading software testing initiatives, defining test cases, and implementing automation solutions. Collaborate with teams to enhance quality engineering strategies and ensure com...
2 weeks ago
Senior Technical Program Manager (Remote, US)
$185K - $225K *
Lead the charge in delivering complex, cross-functional programs that drive innovation in consumer energy products. Collaborate with diverse teams to establish frameworks, manage risks, and ensure suc...
3 weeks ago
$110K - $130K *
Empower your career as a Platform Engineer, driving innovation in system architecture and cloud technologies. Collaborate with cross-functional teams to enhance platform efficiency and guide junior en...
3 weeks ago
Principal Software Engineer - Emerging Technology & AI - Remote
$177K - $236K *
Transform the future of technology as a Principal Software Engineer, leading AI experimentation and prototyping. Collaborate across teams to design scalable solutions, mentor engineers, and drive inno...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.