Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$183K - $216K *

Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$159K - $235K *

Optimize security infrastructure by designing and implementing robust access management and secrets storage solutions, ensuring seamless integration and operational excellence across engineering teams...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$130K - $155K *

Collaborate to design and develop scalable solutions for modern data platforms, utilizing Python and cloud technology. Drive innovation through AI-assisted tools, while building robust data pipelines...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $117K *

Optimize our CI/CD pipelines and infrastructure platforms to enhance software delivery. Collaborate with cross-functional teams to improve reliability and efficiency while developing automation soluti...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$125K - $150K *

Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by leading the design of innovative applications that empower network teams. Collaborate with cross-functional teams to create user-centric solutions, transforming complex data into i...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $164K *

Drive transformative data migration initiatives by leading complex enterprise conversions, aligning cross-functional teams, and enhancing operational strategies to ensure successful onboarding and cus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$167K - $176K *

Shape the future of design operations by driving program execution, leveraging AI for efficiency, and managing cross-functional partnerships to enhance creative workflows and deliver impactful design...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $155K *

Champion the safety design and validation of our autonomous trucking system, ensuring rigorous functional safety standards are met across all engineering and operational teams. Drive impactful safety...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Transportation

$250K - $500K+*

Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Drive mobile engineering excellence across diverse product teams, ensuring strategic direction, fostering collaboration, and enhancing delivery. Lead managers, shape architecture, and cultivate a prod...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$157K - $184K *

Empower secure software delivery by designing and maintaining robust CI/CD pipelines, enhancing cloud-native product security, and implementing best practices in software supply chain security. Collab...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $165K *

Create innovative solutions as a Software Engineer, shaping a greenfield platform. Collaborate with teams to automate processes, build data infrastructure, and deliver impactful tools while enjoying a...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $125K *

Join a team that's dedicated to building robust software solutions. Collaborate with cross-functional teams to design, develop, and maintain high-quality applications while ensuring reliability and pe...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$90K - $107K *

Empower enterprises by guiding customers through onboarding and implementation. As a key consultant, you'll drive accountability, promote best practices, and ensure a successful transition to our plat...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Bring your expertise to lead software engineering and web development teams, driving product innovation and ensuring compliance with technical and cybersecurity standards while enhancing collaboration...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $175K *

Engineer and optimize enterprise platforms for diverse environments, ensuring seamless deployment and support. Collaborate with clients to enhance cybersecurity, compliance, and observability solution...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$190K - $200K *

Lead the charge in electrical engineering excellence across multiple campuses, ensuring robust design, validation, and energization of critical infrastructure while integrating onsite generation solut...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Lead the technical direction for AI agent quality, defining metrics and evaluation systems. Collaborate with cross-functional teams to enhance agent performance and ensure quality in production enviro...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$192K - $195K *

Lead the design and implementation of scalable data solutions, driving innovation through technology evaluation and mentoring junior engineers to enhance data processing and delivery quality across mu...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $115K *

Unlock your potential as a full stack engineer, collaborating in an agile team to develop innovative applications and features, while leveraging cutting-edge AI technologies to enhance product offerin...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Elevate your career by leading software testing initiatives, defining test cases, and implementing automation solutions. Collaborate with teams to enhance quality engineering strategies and ensure com...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$185K - $225K *

Lead the charge in delivering complex, cross-functional programs that drive innovation in consumer energy products. Collaborate with diverse teams to establish frameworks, manage risks, and ensure suc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Empower your career as a Platform Engineer, driving innovation in system architecture and cloud technologies. Collaborate with cross-functional teams to enhance platform efficiency and guide junior en...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$177K - $236K *

Transform the future of technology as a Principal Software Engineer, leading AI experimentation and prototyping. Collaborate across teams to design scalable solutions, mentor engineers, and drive inno...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.