Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Architect - Data Platforms & Architecture
$145K - $175K *
Lead the charge in architecting scalable Azure solutions across multi-team programs, aligning client goals with innovative designs. Mentor teams, drive modernization efforts, and ensure high-quality d...
3 days ago
Principal Cloud Engineer - AI Platform
$175K - $250K *
Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...
Reposted 3 days ago
Member of Engineering, Backend - AI
$250K - $250K+*
Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...
Reposted 3 days ago
$135K - $160K *
Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...
1 week ago
$174K - $215K *
Architect the future of vulnerability intelligence by owning product strategy, roadmap, and AI integration. Collaborate with engineering and analysts to deliver impactful solutions that enhance custom...
Today
$59K - $101K *
Elevate your career by contributing to innovative software solutions, collaborating with cross-functional teams to develop secure, user-centered applications while enhancing your engineering skills th...
3 weeks ago
Senior Workforce Solutions Engineer
$104K - $153K *
Unlock your potential by leading the technical delivery of workforce applications. Collaborate with teams to enhance productivity through automation, AI, and integrations, ensuring secure and efficien...
2 weeks ago
$150K - $160K *
Champion cloud and application security by enhancing AWS practices, collaborating with cross-functional teams, and driving continuous improvement to ensure secure and compliant environments...
Reposted 4 days ago
AI Delivery Engineer - AWS Bedrock
$135K - $220K *
Engage with clients to transform business challenges into AI solutions. Collaborate in a multidisciplinary team to develop prototypes and integrate AI applications using AWS services, ensuring quality...
Today
Software Engineer, Java/Python & AI
$150K - $180K *
Lead the development of enterprise-grade applications using Java, Python, and AI technologies. Collaborate with cross-functional teams to design and implement robust software solutions in a dynamic, A...
Today
Senior Strategic Program Manager
$90K - $108K *
Champion high-impact strategic initiatives, collaborating with executives to drive alignment and measurable results across the organization while navigating complexity and change...
5 days ago
Senior Engineering Project Manager - Connectivity
$120K - $140K *
Transform your career by leading complex design change projects from inception to execution. Collaborate with cross-functional teams, manage substantial budgets, and drive innovation in a fast-paced e...
1 week ago
$220K - $250K *
Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...
Reposted today
Lead Machine Learning Engineer
$220K - $270K *
Join a team that's pushing the boundaries of machine learning in autonomous vehicles. Enhance driving capabilities, lead innovative teams, and drive commercial-scale solutions with cutting-edge techno...
Reposted 4 days ago
$135K - $160K *
Lead the charge in quality and validation readiness for complex programs, uniting Engineering, Product, and Customer Success teams. Utilize AI and automation to streamline processes, enhance delivery...
1 week ago
Principal Ruby on Rails Engineer
$96K - $207K *
Join a dynamic team to design and implement innovative technology solutions using Agile practices. Collaborate with cross-functional teams to deliver critical products while enhancing your skills in a...
5 days ago
$95K - $115K *
Elevate automation systems' reliability by providing technical leadership and troubleshooting expertise, ensuring optimal performance in manufacturing environments while collaborating with diverse tea...
Reposted 3 weeks ago
$135K - $196K *
Unlock potential by shaping the demo experience through innovative tooling and infrastructure. Collaborate across teams to enhance product communication and drive secure access solutions, all while le...
5 days ago
$125K - $150K *
Lead the charge in managing and optimizing cloud infrastructure across multiple platforms. Collaborate with teams to enhance product reliability and streamline operations while ensuring security and c...
3 weeks ago
Software Engineering - Data Engineer (Python & Cloud Databases)
$84K - $132K *
Join a dynamic team to design and optimize high-performance databases, build Python ETL pipelines, and support AI initiatives, ensuring data integrity and efficiency for consumer-facing applications...
5 days ago
Director of Engineering, Product
$250K - $290K *
Elevate your career by leading a high-performing engineering team, driving strategy and innovation in web3 technologies. Shape the future of decentralized systems while ensuring top-tier security and...
Reposted today
Senior Technical Program Manager
$125K - $150K *
Manage complex cybersecurity verification programs across large-scale data center projects. Lead coordination among diverse teams, ensuring operational readiness and technical integration throughout c...
4 days ago
Forward Deployed Engineer (Atlanta, Georgia)
$110K - $130K *
Transform client challenges into innovative AI solutions. Collaborate with teams to design, build, and deploy production-quality software, ensuring reliable AI applications that deliver measurable imp...
Reposted 4 days ago
$98K - $206K *
Drive innovation as a Senior Endpoint Engineer, collaborating with a skilled team to enhance endpoint management and automation, ensuring efficient deployments and robust security for critical systems...
Today
$150K - $180K *
Engineer cutting-edge blockchain infrastructure for financial markets. Drive architecture, design proofs of concept, and ensure interoperability while collaborating with teams to meet institutional re...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.