Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$120K - $145K *
Unlock potential by designing and implementing innovative knowledge graph solutions for healthcare data. Collaborate with cross-functional teams to translate complex requirements into scalable, produc...
1 week ago
$110K - $130K *
Lead the charge in developing a sophisticated healthcare SaaS platform by designing, implementing, and maintaining full-stack features that enhance user experience and system performance in a dynamic...
3 weeks ago
$150K - $180K *
Champion innovative design solutions as a Principal Product Designer, leading UX strategy and AI experiences for a complex platform. Drive workflow transformation and mentor talent while shaping the f...
5 days ago
$81K *
Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...
2 weeks ago
Senior Architect - Data Processing Systems, Analytics and Data Intelligence
$184K - $356K *
Transform data processing architectures by optimizing performance and efficiency. Collaborate with diverse teams to enhance user experiences and drive innovation in hardware-software co-design for cut...
Reposted 2 weeks ago
$110K - $130K *
Join a team that's dedicated to enhancing system reliability and performance. You'll drive automation and continuous improvement initiatives, ensuring high availability and minimal downtime for missio...
1 week ago
$110K - $130K *
Optimize operational excellence by enhancing system reliability and automating processes. Leverage your expertise in AWS and cloud technologies to ensure high availability and performance of mission-c...
1 week ago
Senior Director, Client Operations
$192K - $266K *
Drive best-in-class travel support through strategic leadership and operational excellence. Oversee lodging, flights, and customer advocacy, fostering a culture of continuous improvement and exception...
Reposted 2 weeks ago
$130K - $172K *
Transform your career by leading the administration and optimization of key SaaS collaboration and endpoint management platforms, ensuring security and efficiency across the organization while collabo...
4 days ago
$91K - $118K *
Lead the development and enhancement of critical software applications, ensuring performance and stability while collaborating with cross-functional teams to deliver market-driven solutions and suppor...
Yesterday
$110K - $130K *
Empower creativity by transforming ambitious concepts into innovative digital experiences. Collaborate with designers and engineers to prototype and build interactive projects, leveraging your technic...
6 days ago
$110K - $130K *
Join a team that's dedicated to delivering high-quality software solutions using C# and .NET technologies. Collaborate in an Agile environment to drive innovation and optimize performance while suppor...
2 weeks ago
$86K - $97K *
Optimize your career by testing software for advanced mission planning systems. Collaborate with a dynamic team to enhance processes and ensure software meets operational standards while maintaining r...
Today
$86K - $97K *
Join our team as a Software Test Engineer, where you'll execute test procedures, manage defects, and enhance software quality for mission-critical systems. Collaborate with cross-functional teams to e...
Today
Staff Developer Platform Engineer
$183K - $200K *
Transform the Developer Platform by enhancing infrastructure and deployment processes. Collaborate with teams to ensure safe, efficient product delivery while driving adoption of innovative tooling an...
2 weeks ago
$100K - $120K *
Join a team that's dedicated to enhancing healthcare technology by developing and maintaining our Electronic Health Record platform using Ruby. Collaborate in an agile environment to deliver impactful...
2 weeks ago
$95K - $115K *
Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...
5 days ago
Senior Product Designer, Mobile
$110K - $130K *
Unlock potential by designing intuitive AI experiences for diverse construction teams, blending interaction and visual design. You'll create mobile-first solutions for Superintendents and DCOs, ensuri...
Reposted yesterday
Senior System Software Engineer - Datacenter Power Management
$224K - $431K *
Innovate cutting-edge software for data center power management, spanning architecture, firmware, and AI workloads. Drive product lifecycle from design to deployment, enhancing performance and energy...
1 week ago
Senior Partner Solutions Architect, Strategic Partnerships
$115K - $194K *
Lead the technical strategy for strategic partnerships, transforming partner needs into integrations and influencing product design. Collaborate with R&D to evaluate AI models and enhance GitLab's off...
2 weeks ago
Senior Test Engineer - Systems
$93K - $125K *
Join us as a Senior Test Engineer to lead the planning and execution of complex product testing, utilizing your expertise to assess performance criteria across various systems while collaborating with...
Reposted 1 week ago
$110K - $130K *
Engage with sales teams to identify prospects and demonstrate solutions that enhance organizational security. Educate clients on challenges and drive meetings to provide tailored solutions, ensuring e...
2 weeks ago
Software Engineer II, UI/UX React (Remote)
$75K - $130K *
Innovate software solutions by transforming business needs into technical excellence. Collaborate across teams to enhance software quality, reliability, and maintainability while mentoring peers and d...
3 weeks ago
$95K - $115K *
Bring your expertise to develop and maintain payer customer implementations, focusing on backend and frontend development. Collaborate with senior engineers to enhance healthcare applications impactin...
Reposted today
$113K - $170K *
Lead the charge in transforming customer integrations by driving technical discovery, scoping complex implementations, and ensuring successful onboarding for high-stakes accounts. Collaborate closely...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.