Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$145K - $185K *

Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $150K *

Join our dynamic team as a Senior Engine Programmer, where you'll design and optimize core game engine systems, collaborating with external developers to enhance performance across multiple games. You...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$186K - $218K *

Drive the development and operation of backend services for a subscription product, enhancing user experience and retention through scalable solutions and cross-functional collaboration...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$87K - $230K *

Join a team that's redefining data solutions by leveraging Google Cloud Platform expertise. As a Senior Data Engineer, you'll build data pipelines, support AI development, and collaborate with clients...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$168K - $285K *

Drive product strategy for tenant scale and unified deployment across platforms, collaborating with engineering and product teams to enhance scalability and customer experience while mentoring peers a...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to building and enhancing robust full-stack solutions. You'll take ownership of features from design to deployment, collaborating with engineers to deliver high-quality, s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Staffing

$120K - $145K *

Pioneer the development of secure platform capabilities for enterprise clients, collaborating across teams to define product scope, manage complex requirements, and ensure successful delivery in highl...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $160K *

Elevate your career by joining a dynamic team as a Data Engineer, owning end-to-end data systems and driving platform modernization. You'll improve data reliability and work closely with cross-functio...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$123K - $202K *

Innovate advanced GIS and remote sensing software for defense and intelligence, collaborating with a skilled team to enhance analytical workflows and imagery processing capabilities, while mentoring j...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$185K - $230K *

Advance your career by ensuring seamless performance of AI systems in diverse environments. Collaborate with customers and teams, automating and maintaining infrastructure for reliability across uncla...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead the charge in developing a cutting-edge AI product, managing a high-performing team of engineers while ensuring quality, reliability, and speed in delivery. Collaborate closely with Product and D...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $240K *

Champion innovation by building and operating secure infrastructures for federal and partner environments, ensuring seamless deployments and reliable operations across diverse cloud and on-premises pl...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$140K - $160K *

Accelerate progress at our integration platforms, ensuring scalable, reliable data flows. You'll design, build, and optimize workflows while collaborating across teams to enhance performance and custo...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $345K *

Lead the charge in database excellence to enhance reliability, performance, and sustainability of GitLab's datastores. Shape long-range strategies while collaborating across teams to drive success in...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$175K - $222K *

Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in transforming enterprise security implementations into measurable success. Drive customer outcomes, manage complex programs, and build trusted relationships with executives to ensure...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Lead a high-performance engineering team, driving strategy and innovation for Corporate Payments services while aligning technology with business goals. Foster collaboration and continuous improvement...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $155K *

Join a team that's redefining data infrastructure by owning and optimizing our data pipelines, warehouse, and modeling layers. Collaborate with cross-functional teams to ensure data integrity and driv...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $153K *

Lead the enhancement and administration of enterprise endpoint security technologies, collaborating with cross-functional teams to optimize security processes and improve detection capabilities in a g...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $165K *

Engage with our Cal AI team to enhance user experiences through innovative iOS development. Collaborate, mentor, and implement high-quality features that empower users on their health journeys while f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$130K - $155K *

Unlock potential by leading the design and development of enterprise applications using C# and .NET, driving modern software practices, and collaborating with cross-functional teams to implement secur...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$128K - $165K *

Lead reliability initiatives across complex systems, driving automation and observability. Collaborate with teams to enhance operational outcomes, manage incidents, and mentor engineers, ensuring comp...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$97K - $162K *

Innovate backend solutions for critical national security missions, developing APIs and data capabilities in cloud environments. Collaborate with Defense and Intelligence sectors to solve complex tech...

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$145K - $150K *

Lead the charge in developing web-based dissemination tools for external users, collaborating with developers to enhance data visualization and streamline CI/CD processes using modern frameworks and b...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$173K - $182K *

Lead the charge in designing and deploying impactful machine learning systems. Collaborate across teams to drive innovation and improve business outcomes in a fast-paced environment, leveraging your e...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.