Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Ecosystem Operations Manager
$104K - $176K *
Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...
1 week ago
Principal Technical Product Manager
$138K - $165K *
Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...
2 weeks ago
Senior Software Engineer-C#, SQL, Azure (Hybrid in Kansas City, MO)
$110K - $130K *
Optimize our software architecture as a senior engineer, leading the design, development, and maintenance of core applications while mentoring team members and enhancing product features for scalabili...
Reposted 1 week ago
Senior Workplace Engineering Lead
$87K - $230K *
Champion modern workplace transformations by leading technical investigations, collaborating with cross-functional teams, and enhancing employee technology experiences through scalable solutions...
1 week ago
Azure Application Engineering Lead
$125K - $150K *
Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...
1 week ago
Staff Fullstack Engineer - Platform - App Core Usage | US | Remote
$174K - $209K *
Drive innovation by enhancing backend systems and APIs for billing and usage calculations. Collaborate with cross-functional teams to improve reliability and efficiency, ensuring seamless customer exp...
2 weeks ago
Senior Director, Dedicated Infrastructure & Platforms
$279K - $349K *
Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...
1 week ago
$110K - $130K *
Shape the future of cloud-native applications by designing and developing scalable solutions that enhance Workforce Management and Customer Experience. Collaborate with cross-functional teams to deliv...
3 weeks ago
$90K - $113K *
Transform data management processes by bridging business needs with technical execution. Support data pipeline maintenance, ensure data quality, and assist in BI reporting to enhance operational effic...
3 weeks ago
Software Engineer I - Top Secret
$88K - $154K *
Explore a dynamic role in cyber network operations, developing tools that support national security missions. Collaborate with a skilled team to enhance software capabilities and contribute to critica...
Today
Senior Machine Learning Engineer, ML Infrastructure- Online
$210K - $273K *
Drive the evolution of a robust online ML inference platform, enhancing model deployment, performance, and safety in high-traffic environments by collaborating with cross-functional teams and spearhea...
Reposted 3 days ago
Manager, Software Engineering (Resilience Engineering)
$204K - $290K *
Manage the Resilience Engineering team to enhance system reliability through production load testing and chaos engineering while fostering a proactive safety culture across engineering practices...
Reposted 6 days ago
Senior Software Engineer – Intelligent Platforms & Agents
$107K - $195K *
Lead the charge in developing advanced platforms that automate operations and enhance AI-driven interactions. This hands-on role combines technical leadership with coding, mentoring, and ensuring comp...
1 week ago
Senior Product Manager, Growth
$181K - $213K *
Transform product-led growth by crafting data-driven strategies, enhancing customer experiences with AI, and driving account expansion through collaboration and experimentation across teams...
3 weeks ago
Senior Site Reliability Engineer II
$120K - $145K *
Drive system reliability and scalability as a Senior Site Reliability Engineer, focusing on automation and collaboration with software teams to enhance performance and maintain service objectives acro...
2 weeks ago
Senior Data Analytics Engineer
$95K - $120K *
Unlock potential by delivering actionable insights through data analysis, visualization, and reporting. Collaborate across departments to enhance decision-making with automated dashboards and performa...
4 days ago
Senior Software Development Engineer
$83K - $222K *
Drive innovation by delivering high-quality web applications and interactive dashboards. Collaborate with cross-functional teams to integrate AI capabilities and build resilient APIs in a fast-paced...
Reposted 2 weeks ago
Lead Engineer, Merchandise Technology
$125K - $160K *
Shape the future of global merchandising technology by leading engineering efforts, driving modernization, and ensuring high-quality delivery across diverse platforms. Collaborate with teams to implem...
3 weeks ago
Senior Technical Program Manager
$115K - $275K *
Manage the delivery of GPU clusters for AI workloads by coordinating teams across engineering, networking, and operations. Develop strategies, manage risks, and ensure timely, quality launches to scal...
Reposted 1 week ago
Senior Software Engineer, AI Platform (Remote)
$196K - $222K *
Unlock innovative AI solutions by designing and building autonomous coding agents that enhance operational efficiency and integrate seamlessly with existing systems, driving measurable improvements in...
Reposted 3 weeks ago
Full-Stack Engineer (Frontend Leaning) - Studio
$110K - $130K *
Empower users by creating intuitive video editing tools and features. Collaborate on innovative UI designs and enhance existing functionalities, ensuring a seamless experience for editors transitionin...
Reposted today
$95K - $115K *
Shape the future of cloud solutions by designing and deploying Azure services, ensuring security and scalability while automating workflows and providing technical support for cloud infrastructure and...
2 weeks ago
$95K - $115K *
Join a team that's redefining cloud solutions by designing and deploying Azure services, ensuring security and scalability while automating workflows and enhancing performance through innovative techn...
2 weeks ago
$130K - $160K *
Lead the end-to-end customer onboarding process, managing cross-functional teams to ensure timely delivery and value realization. Collaborate with customers to provide expert guidance and drive succes...
3 weeks ago
$120K - $145K *
Join a dynamic team to drive technical success and adoption across enterprise accounts. Leverage your expertise in project management and technical execution to enhance deployment health and fuel acco...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.