Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$104K - $176K *

Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Optimize our software architecture as a senior engineer, leading the design, development, and maintenance of core applications while mentoring team members and enhancing product features for scalabili...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$87K - $230K *

Champion modern workplace transformations by leading technical investigations, collaborating with cross-functional teams, and enhancing employee technology experiences through scalable solutions...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$174K - $209K *

Drive innovation by enhancing backend systems and APIs for billing and usage calculations. Collaborate with cross-functional teams to improve reliability and efficiency, ensuring seamless customer exp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$279K - $349K *

Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Shape the future of cloud-native applications by designing and developing scalable solutions that enhance Workforce Management and Customer Experience. Collaborate with cross-functional teams to deliv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $113K *

Transform data management processes by bridging business needs with technical execution. Support data pipeline maintenance, ensure data quality, and assist in BI reporting to enhance operational effic...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$88K - $154K *

Explore a dynamic role in cyber network operations, developing tools that support national security missions. Collaborate with a skilled team to enhance software capabilities and contribute to critica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$210K - $273K *

Drive the evolution of a robust online ML inference platform, enhancing model deployment, performance, and safety in high-traffic environments by collaborating with cross-functional teams and spearhea...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$204K - $290K *

Manage the Resilience Engineering team to enhance system reliability through production load testing and chaos engineering while fostering a proactive safety culture across engineering practices...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $195K *

Lead the charge in developing advanced platforms that automate operations and enhance AI-driven interactions. This hands-on role combines technical leadership with coding, mentoring, and ensuring comp...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$181K - $213K *

Transform product-led growth by crafting data-driven strategies, enhancing customer experiences with AI, and driving account expansion through collaboration and experimentation across teams...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive system reliability and scalability as a Senior Site Reliability Engineer, focusing on automation and collaboration with software teams to enhance performance and maintain service objectives acro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $120K *

Unlock potential by delivering actionable insights through data analysis, visualization, and reporting. Collaborate across departments to enhance decision-making with automated dashboards and performa...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $222K *

Drive innovation by delivering high-quality web applications and interactive dashboards. Collaborate with cross-functional teams to integrate AI capabilities and build resilient APIs in a fast-paced...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $160K *

Shape the future of global merchandising technology by leading engineering efforts, driving modernization, and ensuring high-quality delivery across diverse platforms. Collaborate with teams to implem...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$115K - $275K *

Manage the delivery of GPU clusters for AI workloads by coordinating teams across engineering, networking, and operations. Develop strategies, manage risks, and ensure timely, quality launches to scal...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$196K - $222K *

Unlock innovative AI solutions by designing and building autonomous coding agents that enhance operational efficiency and integrate seamlessly with existing systems, driving measurable improvements in...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Empower users by creating intuitive video editing tools and features. Collaborate on innovative UI designs and enhance existing functionalities, ensuring a seamless experience for editors transitionin...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Shape the future of cloud solutions by designing and deploying Azure services, ensuring security and scalability while automating workflows and providing technical support for cloud infrastructure and...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Join a team that's redefining cloud solutions by designing and deploying Azure services, ensuring security and scalability while automating workflows and enhancing performance through innovative techn...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$130K - $160K *

Lead the end-to-end customer onboarding process, managing cross-functional teams to ensure timely delivery and value realization. Collaborate with customers to provide expert guidance and drive succes...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic team to drive technical success and adoption across enterprise accounts. Leverage your expertise in project management and technical execution to enhance deployment health and fuel acco...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.