Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$126K - $137K *

Drive the evolution of a critical Vehicle Integration System, leveraging cloud software and embedded systems. Collaborate with cross-functional teams to enhance vehicle capabilities, ensuring seamless...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join our team to shape external developer experiences through impactful APIs and SDKs. You'll evolve documentation and tools while collaborating across teams to enhance our growing platform and delive...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$128K - $214K *

Empower cross-functional teams to deliver complex technical programs, ensuring alignment with business goals. Lead planning, execution, and stakeholder communication while fostering a collaborative en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Champion the technical integration of partner ecosystems, ensuring seamless onboarding and operational reliability. Drive API discovery, documentation, and troubleshooting while collaborating with int...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate your career as you drive QA best practices and develop automation frameworks with Playwright. Collaborate with teams, enhance software quality, and mentor junior engineers while ensuring effic...

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Elevate security practices by building and managing a comprehensive security program. Collaborate with engineers to identify vulnerabilities, implement automated checks, and ensure robust protection a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $260K *

Lead the charge in browser engine innovation by designing experiments, implementing changes, and collaborating across disciplines to enhance performance and correctness in web technologies...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$124K - $210K *

Drive customer success by leading a team of engineers to enhance GitLab adoption, develop scalable enablement programs, and collaborate with cross-functional teams to achieve measurable business outco...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$116K - $155K *

Join a dynamic team as you design and optimize Oracle EBS integrations, enhancing supply chain solutions. Utilize your expertise to drive impactful software engineering efforts that elevate business p...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$97K - $126K *

Champion the development of high-performance real-time systems, ensuring reliability and maintainability. Collaborate with peers to implement solutions, enhance testing, and contribute to a culture of...

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Innovate and optimize CI/CD pipelines while integrating AI-driven automation to enhance developer enablement. Collaborate with agile teams to ensure secure, efficient software delivery and champion a...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $210K *

Drive the technical vision for complex systems, leading cross-team initiatives and enhancing engineering standards. Own reliability and scalability of core infrastructure while mentoring engineers and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Design and optimize evaluation systems for AI agents, enhancing performance and quality through innovative metrics and benchmarks. Collaborate with cross-functional teams to ensure agents meet user ne...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $194K *

Unlock your potential as a strategic partner to senior Engineering leaders, driving organizational change and fostering a high-performance culture across global teams in a fast-paced tech environment...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Drive the end-to-end lifecycle of innovative AI-powered products, shaping strategy and vision while collaborating cross-functionally to deliver exceptional business and customer value through effectiv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $213K *

Elevate digital engineering by designing and implementing scalable software solutions, collaborating with cross-functional teams, and driving innovation in data analytics projects to meet business obj...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$186K - $218K *

Shape the future of AI-driven trading by developing backend services that enhance user experience and ensure reliable execution for millions of customers. Collaborate across teams to deliver innovativ...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Elevate project delivery by managing integrated schedules for data center builds, ensuring timely execution across teams and partners. Drive risk management and governance while building scalable proc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Elevate customer success by implementing privacy-first healthcare marketing solutions. As an Implementation Engineer, you'll guide clients through technical setups, ensuring optimal performance and co...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $145K *

Develop innovative full stack applications to enhance legal operations and compliance. Collaborate with cross-functional teams to deliver secure, scalable solutions using modern technologies and cloud...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $165K *

Join a team that's redefining the shopping experience by enhancing search capabilities. Collaborate with stakeholders to balance speed and quality, ensuring robust backend systems while fostering comm...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$195K - $270K *

Elevate borrower experiences by leading a fullstack engineering team to create intuitive, reliable web and mobile solutions. Shape technical strategy and modernize architecture while fostering collabo...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Elevate your career by driving data engineering excellence in Palantir Foundry, transforming legacy systems into robust pipelines and applications while collaborating with cross-functional teams to de...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$187K - $243K *

Engage in building and scaling systems that serve millions. As a seasoned engineer, influence technical decisions, foster AI adoption, and lead projects from concept to deployment while collaborating...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$163K - $226K *

Lead the AI enablement initiative, crafting tools and workflows to empower engineers across the organization, enhancing productivity and safety through innovative AI technologies and practices...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.