Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$125K - $225K *

Unlock innovation by building scalable, user-centric applications in TypeScript and React. Collaborate with engineering teams to enhance AI-driven solutions, ensuring top performance in ML observabili...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$232K - $341K *

Unlock potential by leading the technical strategy for enterprise architecture, focusing on AI integration and cloud migration. Collaborate with engineers to solve complex challenges and drive innovat...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$93K - $150K *

Optimize infrastructure and CI/CD pipelines to empower engineering teams in delivering AI-powered products efficiently. Collaborate closely with product and data engineers, leading projects from incep...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Shape the future of partner engagement by leading global programs that enhance value across the customer lifecycle. Collaborate with cross-functional teams to streamline processes, improve partner exp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$121K - $191K *

Join the team to design and develop scalable software solutions for healthcare supply chain transactions. Collaborate with cross-functional partners to enhance the rules engine and deliver high-qualit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $190K *

Lead the design and evolution of scalable data architecture, providing technical leadership across teams to deliver reliable, secure, and cost-effective data solutions while shaping emerging capabilit...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$208K - $250K *

Unlock the potential of enterprise deployment solutions by defining product vision and strategy. Collaborate with cross-functional teams to adapt offerings for compliance-driven environments, ensuring...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join us to design and develop cutting-edge enterprise software solutions using Java, Python, and AI technologies. Collaborate in a dynamic environment that values innovation and technical excellence w...

4 days ago

  •   5 - 7 years exp.  •   Staffing

$135K - $175K *

Engineer your career with a Senior Software Safety Engineer role focused on developing safety-critical autonomous systems. Collaborate with a multi-disciplinary team to enhance software safety process...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$174K - $220K *

Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$173K - $290K *

Champion innovation in product development platforms, driving strategy and execution for AI-first tools that enhance collaboration and efficiency across teams. Lead the evolution of platforms, ensurin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $170K *

Innovate with AI to enhance HR software. Design and develop scalable web services, lead initiatives, and mentor engineers while focusing on user experience and collaboration in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$99K - $232K *

Lead a team in developing innovative data solutions using advanced technologies. Transform raw data into actionable insights, driving business growth while mentoring and inspiring team members to achi...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$128K - $252K *

Drive mobile engineering initiatives that enhance personalized marketing and customer engagement. Lead cross-functional teams in delivering scalable iOS and Android solutions while aligning technical...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$128K - $252K *

Drive mobile engineering initiatives that enhance personalized marketing and customer engagement. Lead cross-functional teams in delivering scalable iOS and Android solutions while ensuring technical...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$106K - $284K *

Join a dynamic team to design and deliver innovative iOS solutions that enhance customer health experiences. Collaborate across functions, lead technical initiatives, and drive the development of secu...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$187K - $234K *

Empower the Integrations team to scale impact by leading third-party integrations, creating reusable capabilities, and fostering a collaborative culture that drives effective delivery and continuous i...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$112K - $155K *

Accelerate progress at a leading tech firm by developing scalable, cloud-native APIs. Collaborate with cross-functional teams to enhance core offerings and lead discussions on software architecture, e...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$138K - $230K *

Join a dynamic team to deliver professional services, guiding public sector clients in adopting GitLab through installations, migrations, and training. Balance technical expertise with project managem...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$253K - $298K *

Lead transformative initiatives by leveraging AI and engineering excellence to redefine compliance operations. This role focuses on building high-performing teams and designing scalable solutions that...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$217K - $303K *

Innovate with us to lead a high-performing engineering team, shaping a scalable AI-powered knowledge graph platform that enhances data quality and drives impactful user experiences across multiple app...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$150K - $180K *

Accelerate progress at a high-growth infrastructure team managing Kubernetes platforms across multiple clouds. You'll enhance GPU resource efficiency and ensure system reliability while collaborating...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $180K *

Drive innovative electrical design solutions for high-density compute environments. Collaborate across teams to ensure compliance with industry standards while mentoring junior engineers. Make a signi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $160K *

Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $180K *

Unlock potential by designing and deploying AI-driven automation systems that enhance logistics workflows. Collaborate across teams to transform complex processes into efficient, reliable solutions, e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.