Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior AI Product Engineer, Fullstack
$125K - $225K *
Unlock innovation by building scalable, user-centric applications in TypeScript and React. Collaborate with engineering teams to enhance AI-driven solutions, ensuring top performance in ML observabili...
Reposted 4 days ago
Distinguished Software Engineer
$232K - $341K *
Unlock potential by leading the technical strategy for enterprise architecture, focusing on AI integration and cloud migration. Collaborate with engineers to solve complex challenges and drive innovat...
2 weeks ago
$93K - $150K *
Optimize infrastructure and CI/CD pipelines to empower engineering teams in delivering AI-powered products efficiently. Collaborate closely with product and data engineers, leading projects from incep...
1 week ago
$110K - $130K *
Shape the future of partner engagement by leading global programs that enhance value across the customer lifecycle. Collaborate with cross-functional teams to streamline processes, improve partner exp...
1 week ago
Software Engineer II - Java, Spring, AWS, CI/CD
$121K - $191K *
Join the team to design and develop scalable software solutions for healthcare supply chain transactions. Collaborate with cross-functional partners to enhance the rules engine and deliver high-qualit...
2 weeks ago
$145K - $190K *
Lead the design and evolution of scalable data architecture, providing technical leadership across teams to deliver reliable, secure, and cost-effective data solutions while shaping emerging capabilit...
3 weeks ago
Staff Product Manager, Enterprise Deployment Solutions | USA | Remote
$208K - $250K *
Unlock the potential of enterprise deployment solutions by defining product vision and strategy. Collaborate with cross-functional teams to adapt offerings for compliance-driven environments, ensuring...
2 weeks ago
Principal / Senior Principal Software Engineer, Java/Python & AI
$150K - $180K *
Join us to design and develop cutting-edge enterprise software solutions using Java, Python, and AI technologies. Collaborate in a dynamic environment that values innovation and technical excellence w...
4 days ago
Senior Software Safety Engineer
$135K - $175K *
Engineer your career with a Senior Software Safety Engineer role focused on developing safety-critical autonomous systems. Collaborate with a multi-disciplinary team to enhance software safety process...
3 weeks ago
Staff Engineer Cloud Scalability
$174K - $220K *
Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...
Reposted today
Principal Product Manager, Product Development Platforms
$173K - $290K *
Champion innovation in product development platforms, driving strategy and execution for AI-first tools that enhance collaboration and efficiency across teams. Lead the evolution of platforms, ensurin...
2 weeks ago
$150K - $170K *
Innovate with AI to enhance HR software. Design and develop scalable web services, lead initiatives, and mentor engineers while focusing on user experience and collaboration in a dynamic environment...
1 week ago
Forward Deployed Software Engineer-Palantir Foundry-Manager
$99K - $232K *
Lead a team in developing innovative data solutions using advanced technologies. Transform raw data into actionable insights, driving business growth while mentoring and inspiring team members to achi...
1 week ago
$128K - $252K *
Drive mobile engineering initiatives that enhance personalized marketing and customer engagement. Lead cross-functional teams in delivering scalable iOS and Android solutions while aligning technical...
2 weeks ago
$128K - $252K *
Drive mobile engineering initiatives that enhance personalized marketing and customer engagement. Lead cross-functional teams in delivering scalable iOS and Android solutions while ensuring technical...
2 weeks ago
Staff Software Development Engineer - iOS
$106K - $284K *
Join a dynamic team to design and deliver innovative iOS solutions that enhance customer health experiences. Collaborate across functions, lead technical initiatives, and drive the development of secu...
Yesterday
Engineering Manager, Integrations
$187K - $234K *
Empower the Integrations team to scale impact by leading third-party integrations, creating reusable capabilities, and fostering a collaborative culture that drives effective delivery and continuous i...
6 days ago
Sr. Software Engineer (C# .NET)
$112K - $155K *
Accelerate progress at a leading tech firm by developing scalable, cloud-native APIs. Collaborate with cross-functional teams to enhance core offerings and lead discussions on software architecture, e...
3 weeks ago
Senior Professional Services Engineer - PubSec
$138K - $230K *
Join a dynamic team to deliver professional services, guiding public sector clients in adopting GitLab through installations, migrations, and training. Balance technical expertise with project managem...
6 days ago
Senior Engineering Manager, Payments Platform
$253K - $298K *
Lead transformative initiatives by leveraging AI and engineering excellence to redefine compliance operations. This role focuses on building high-performing teams and designing scalable solutions that...
Reposted 6 days ago
Engineering Manager, Knowledge Graph Platform
$217K - $303K *
Innovate with us to lead a high-performing engineering team, shaping a scalable AI-powered knowledge graph platform that enhances data quality and drives impactful user experiences across multiple app...
3 weeks ago
Lead Platform Engineer/Architect - HPC, Kubernetes
$150K - $180K *
Accelerate progress at a high-growth infrastructure team managing Kubernetes platforms across multiple clouds. You'll enhance GPU resource efficiency and ensure system reliability while collaborating...
3 weeks ago
Senior Electrical Design Engineer
$135K - $180K *
Drive innovative electrical design solutions for high-density compute environments. Collaborate across teams to ensure compliance with industry standards while mentoring junior engineers. Make a signi...
1 week ago
PMRT - Senior Software Engineer (Remote)
$140K - $160K *
Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...
1 week ago
Senior AI Engineer (Automation)
$120K - $180K *
Unlock potential by designing and deploying AI-driven automation systems that enhance logistics workflows. Collaborate across teams to transform complex processes into efficient, reliable solutions, e...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.