Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$148K - $201K *

Empower application teams by integrating, securing, and deploying software in Kubernetes environments. Collaborate across platforms to enhance CI/CD processes and ensure reliable operations, driving i...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Advance quality engineering by leading automation architecture and strategy across teams. Collaborate with Engineering and Product to enhance testing practices, ensuring high standards and effective r...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Staffing

$130K - $160K *

Champion the migration to a modern Databricks lakehouse, designing robust data pipelines and ensuring data quality. Collaborate with teams to enhance analytics capabilities and set technical standards...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$123K - $217K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Drive platform architecture and strategy, owning scalable production environments. Lead cross-team collaboration, mentor engineers, and advocate for DevSecOps practices while solving complex technical...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $184K *

Lead the charge in enhancing platform security and infrastructure as a Senior Software Engineer. Utilize your Python expertise and SRE mindset to drive critical improvements, mentor teammates, and ens...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform fragmented IT landscapes as you lead complex service integration projects, improving data flow and visibility across hybrid cloud and on-premise environments. Guide cross-functional teams an...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Lead cross-functional teams to drive excellence in software development for a SaaS platform, ensuring timely delivery and high-quality outcomes while fostering a collaborative engineering culture. Inn...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Unlock your potential by driving software innovation in investment technology. Collaborate with cross-functional teams to deliver cutting-edge applications that enhance risk management and investment...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $185K *

Transform the technology landscape by leading cross-functional teams to enhance Medicaid Enterprise Systems, driving system architecture improvements and mentoring engineers towards high-quality, secu...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Join a dynamic team to design and build a robust data platform that enhances product performance and supports AI initiatives, ensuring data integrity and accessibility for internal and customer-facing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Engineer robust integrations between diverse DMP platforms, enhancing productivity through API development, coding best practices, and debugging across multiple programming languages while ensuring ti...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Develop reliable applications by collaborating with IT leadership and users. Oversee projects from requirements gathering to deployment, ensuring software meets business needs while utilizing AI tools...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Unlock potential by transforming business needs into reliable applications. Collaborate with IT leadership to develop, test, and support innovative solutions, ensuring software effectively addresses p...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Optimize secure cloud infrastructure and automate compliance controls while enhancing operational efficiency. Collaborate with stakeholders to ensure reliability and security in a dynamic environment...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Solve security challenges by owning and enhancing our security program. Lead CorpSec, SecOps, and compliance efforts while building a robust security culture in a fast-paced, remote environment...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$220K - $265K *

Lead the charge in building a high-performing mobile engineering team, driving technical execution and culture. Oversee multi-persona mobile experiences, architecture, and release operations, shaping...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$77K - $202K *

Join a dynamic team as you leverage advanced technologies to design and develop data solutions. Transform raw data into actionable insights, manage client relationships, and inspire teams while drivin...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$155K - $173K *

Join a team that's driving engineering excellence by designing scalable systems, influencing cross-team initiatives, and delivering high-impact solutions while mentoring engineers and upholding high s...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Media

$140K - $180K *

Shape the future of our iOS platform by designing and implementing scalable features. Collaborate with cross-functional teams to deliver innovative solutions that enhance client interactions with emis...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $145K *

Engineer and enhance the 1035YellowPages platform as a senior developer, responsible for full-stack development and client integration. Lead efforts in code ownership, debugging, and support while lev...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$136K - $160K *

Elevate operations through AI-driven automation to enhance incident management, streamline ticket resolution, and optimize service health with self-healing observability, all while collaborating acros...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$114K - $165K *

Join our dynamic team to lead the development of high-performance backend solutions. Leverage your expertise in Java, microservices, and real-time data streaming to drive innovation and mentor a talen...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $225K *

Unlock innovation by building scalable, user-centric applications in TypeScript and React. Collaborate with engineering teams to enhance AI-driven solutions, ensuring top performance in ML observabili...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$232K - $341K *

Unlock potential by leading the technical strategy for enterprise architecture, focusing on AI integration and cloud migration. Collaborate with engineers to solve complex challenges and drive innovat...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.