Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Staff Software Engineer (Customer Platform)
$205K - $231K *
Join a team that's redefining software supply chain security. As a Staff Software Engineer, you'll lead backend system design, API development, and cross-team collaboration, driving impactful solution...
3 weeks ago
Staff Software Engineer, Trajectory Generation & Controls
$135K - $160K *
Shape the future of autonomous driving by leading trajectory generation and controls. Collaborate across teams to deliver safe, optimized solutions while enhancing vehicle performance through innovati...
2 weeks ago
Staff Software Engineer, Applied AI
$160K - $200K *
Join a team that's redefining operational efficiency by architecting robust internal tools and applying AI to real-world challenges. You'll lead technical direction, drive impactful decisions, and enh...
1 week ago
Senior Software Engineer II, Ads Data Solutions Engineering
$192K - $202K *
Lead the technical roadmap and modernize data solutions infrastructure, enhancing off-platform integrations and measurement capabilities while driving AI-first engineering initiatives and cross-team c...
Reposted 4 days ago
Staff Software Engineer, Payments (AirCover Insurance Platform)
$212K - $265K *
Advance your career by leading the design of scalable insurance systems, collaborating with cross-functional teams to enhance product offerings and drive technical excellence in a dynamic environment...
4 weeks ago
Staff Software Engineer, Tech Lead, Payroll Onboarding
$193K - $309K *
Innovate scalable software solutions for payroll onboarding, enhancing functionality and reliability. Collaborate with diverse teams, mentor peers, and drive improvements in engineering productivity w...
Reposted 4 weeks ago
Staff Software Engineer, AI Systems
$188K - $265K *
Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...
Reposted 5 days ago
$135K - $160K *
Transform healthcare technology by owning core products, driving architectural decisions, and ensuring high-quality code. Collaborate across teams to deliver impactful solutions that enhance patient c...
5 days ago
Staff Software Engineer - ML/AI
$148K - $254K *
Transform connected systems by designing and deploying advanced anomaly detection models. Lead a team to build robust pipelines, ensuring real-time analysis and integration across AI and engineering t...
2 weeks ago
Staff Software Engineer, Vanta for Government
$150K - $180K *
Elevate your engineering career by leading innovative projects and driving strategic technology direction in a rapidly growing organization. Collaborate across teams to champion excellence and mentor...
Reposted today
Senior Software Development Engineer
$164K - $262K *
Elevate your career by designing and building self-service cloud APIs and services. Collaborate with teams to transform complex cloud operations into reliable, user-friendly products that enhance deve...
Today
Staff Software Engineer, Backend MSSP
$230K - $270K *
Empower innovation as you lead technical initiatives for multi-tenant platforms, guiding architecture and implementation while collaborating across teams to enhance partner capabilities and ensure ser...
4 days ago
Staff Software Engineer, Infrastructure Foundations
$150K - $180K *
Join a team that's transforming multi-cloud infrastructure. As a Staff Software Engineer, you'll design and build a cohesive platform across AWS, GCP, and Azure, leading a multi-component system while...
Today
$110K - $145K *
Shape the future of healthcare technology by designing and implementing innovative care management tools. Collaborate with teams to create reliable software solutions while mentoring others and advanc...
Reposted 1 week ago
Senior Software Engineer, DevOps
$119K - $167K *
Lead the charge in evolving our cloud infrastructure and CI/CD systems. As a Senior DevOps Engineer, you'll enhance security, reliability, and operational efficiency while mentoring a team and ensurin...
Reposted 5 days ago
Staff Software Engineer - Builder Platform
$150K - $180K *
Architect the future of our Builder Platform by leading the design and operation of scalable agent workflows. Collaborate across teams to enhance productivity and drive innovation in AI infrastructure...
Today
$112K - $187K *
Join a dynamic team as a Senior Software Engineer, driving innovation in cloud technology. Collaborate across disciplines, mentor peers, and lead impactful projects that enhance our product suite whil...
Today
Staff Software Engineer, Developer Ecosystem
$217K - $303K *
Lead the charge in shaping the future of our developer platform. Collaborate across backend, platform, and full-stack systems to enhance developer experiences and drive innovation in app development...
Reposted 4 weeks ago
$170K - $200K *
Unlock potential by designing and building innovative billing systems that simplify financial transactions and maximize reimbursements, while leveraging AI to enhance efficiency and user experience in...
2 weeks ago
Staff Software Engineer - Backend
$125K - $150K *
Champion the development of scalable, cloud-native applications, enhancing data pipelines and integrations. Collaborate with teams to transform raw data into actionable insights, driving improvements...
3 weeks ago
Staff Software Engineer, Data Governance & Foundations
$265K - $279K *
Join our team to lead and innovate our data infrastructure, owning the architecture and governance of our open lakehouse. Collaborate cross-functionally, tackle complex challenges, and enhance enginee...
Reposted 4 days ago
Staff Software Engineer, Image Build & Release
$229K - $260K *
Drive the technical direction for building and delivering containerized applications, ensuring reliability and security across deployments. Collaborate with teams to enhance automation and mentor engi...
1 week ago
Senior Software Engineer - Builder Platform
$135K - $160K *
Innovate within a dynamic team to develop and enhance a robust platform for agents and workflows, driving productivity and collaboration across engineering and business functions while ensuring qualit...
Today
Senior Software Engineer II - Enterprise Foundations
$192K - $202K *
Lead the charge in architecting and integrating complex systems for a scalable retail platform. Drive multi-quarter projects, collaborate across teams, and mentor junior engineers while ensuring high...
Reposted 4 days ago
$120K - $130K *
Transform your career by designing and delivering complex full-stack solutions using Java, Spring Boot, and Angular. Collaborate with teams to enhance engineering quality and lead technical initiative...
Reposted 3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.