Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$164K - $229K *

Elevate infrastructure reliability and performance by architecting scalable solutions, collaborating across teams, and driving end-to-end software delivery to enhance user experience and system resili...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$82K - $172K *

Innovate your career as you design and maintain mission-critical software for defense financial systems. Lead a growing team, integrate AI capabilities, and ensure compliance in both classified and un...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$129K - $210K *

Transform issue management by leading a team to develop AI-assisted solutions, ensuring quality and accountability in remediation processes across GRC. Drive engineering excellence while fostering ind...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$168K - $285K *

Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $90K *

Drive data migration solutions by collaborating with teams to design, implement, and test tools that meet customer needs. Leverage technical expertise to bridge business objectives and technical capab...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Champion data excellence by designing and optimizing scalable data platforms. Collaborate with cross-functional teams to enhance performance and drive innovation in data processing, ensuring alignment...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$184K - $356K *

Elevate the future of autonomous software systems by building and optimizing AI agent evaluation frameworks, enhancing usability, reliability, and performance with a collaborative engineering team ded...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $102K *

Contribute to the development and maintenance of secure, scalable solutions in Microsoft 365 and Azure. Collaborate with teams to enhance automation, identity security, and API integrations, ensuring...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$117K - $157K *

Join a team that's transforming enterprise AI solutions through innovative design and deployment. Leverage your expertise to build secure, scalable AI platforms that enhance business processes and dri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$164K - $284K *

Lead and inspire a high-performing software engineering team, driving product innovation and technical excellence while fostering a culture of collaboration and continuous improvement in a fully remot...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $220K *

Champion the evolution of scalable infrastructure in a multi-cloud environment, collaborating with engineering teams to enhance reliability and performance for AI-driven healthcare solutions...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Champion innovative data solutions by designing and maintaining robust data pipelines across Azure and Microsoft Fabric, ensuring high-quality data delivery and governance while leading engineering in...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$121K - $142K *

Elevate automation in software engineering by building AI-driven tools and systems. Collaborate with a focused team to enhance reliability and speed in package and image management, shaping the future...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Transform ideas into secure, scalable applications by collaborating with business users. Leverage modern AI tools and full-stack development skills to deliver innovative solutions in a fast-paced envi...

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $175K *

Transform your career as a Senior Software Engineer, leading cross-functional teams to design and implement Java Spring Boot microservices and RESTful APIs on AWS, driving innovation and operational e...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Unlock potential by leading complex engineering initiatives across Microsoft 365 collaboration services, ensuring secure, reliable solutions while mentoring engineers and enhancing platform health thr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$140K - $160K *

Lead the development of a robust web application by designing, coding, and testing software while mentoring junior engineers. Collaborate on process improvements and ensure compliance with industry re...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$222K - $314K *

Accelerate progress at a pivotal backend engineering role, enhancing critical systems and data integrity while driving innovation through high-stakes projects within an empowered team focused on scala...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $210K *

Engage in client development and system architecture while leading a team to enhance client satisfaction. Collaborate on solutions, mentor staff, and drive growth through effective communication and s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate automation reliability by optimizing robotic systems in logistics. Drive performance, minimize downtime, and enhance operational efficiency through proactive maintenance and continuous improve...

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $130K *

Engage in developing and maintaining scalable applications that meet business needs. Collaborate across teams, troubleshoot issues, and mentor staff while delivering quality code and documentation in...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$115K - $145K *

Elevate your career by designing and optimizing data pipelines that empower analytics and AI solutions. Collaborate with cross-functional teams to ensure data integrity and governance while mentoring...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $135K *

Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.