Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

$168K - $238K *

Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $220K *

Drive the strategy and roadmap for enterprise-scale Computer Vision solutions, collaborating with internal teams to define requirements and ensure successful adoption of AI models across product portf...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$135K - $160K *

Lead the evolution of our GTM Systems Architecture, enhancing Salesforce and its tech stack for AI-native workflows. Collaborate with cross-functional teams to build a trusted data foundation and driv...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $191K *

Lead product strategy and execution by driving cross-functional teams to deliver high-quality solutions. Own the product lifecycle, prioritize impactful features, and leverage customer insights to ali...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$135K - $160K *

Accelerate progress at securing cloud environments by designing robust guardrails and automation. Collaborate with engineering teams to embed security into CI/CD pipelines and ensure compliance across...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $127K *

Join a team that's redefining revenue operations by owning and enhancing our go-to-market technology stack. You'll collaborate across sales and customer success, driving impactful solutions and integr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $165K *

Unlock potential by joining a dynamic engineering team focused on resolving issues, enhancing systems, and automating processes to improve member experiences and operational efficiency...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining healthcare solutions by leading technical demos and driving enterprise sales. Collaborate with executives to translate needs into impactful presentations, ensuring succes...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $165K *

Develop a cutting-edge data ecosystem as a Senior Data Engineer, enhancing analytics, reporting, and machine learning. Collaborate with cross-functional teams to create efficient pipelines and accessi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$125K - $150K *

Drive your career with innovative AI-driven automation solutions that enhance IT operations and user experience. Collaborate across teams to minimize manual tasks, improve efficiency, and implement in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Empower teams by designing and building scalable, secure systems that enhance performance and reliability. Collaborate across disciplines to innovate with AI while maintaining a security-first approac...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$150K - $180K *

Join a team that's shaping the future of DevOps by designing and implementing CI/CD pipelines with cutting-edge technologies. Collaborate with customers and cross-functional teams to enhance their Dev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Join a team that's driving growth and innovation in the industry. You'll own P&L, lead strategic initiatives, and foster key customer relationships while managing a dedicated team to achieve ambitious...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $170K *

Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$170K - $240K *

Engage in a high-impact role to design and build consumer-centric web applications. Collaborate across teams to enhance performance, mentor engineers, and drive technical decisions that scale innovati...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Take ownership of automating workflows across teams by building AI agents using Claude and Microsoft Copilot. Collaborate with various departments to identify automation opportunities, ensuring securi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Join a team that's driving innovation by leveraging your technical expertise to lead and mentor engineers, enhance product performance, and deliver high-quality, cloud-native solutions across diverse...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Media

$110K - $130K *

Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $250K *

Lead the charge in enhancing the reliability and scalability of a global multi-tenant platform. Drive SRE strategy, foster collaboration across teams, and ensure operational excellence while developin...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $217K *

Champion innovation in network delivery by leading a dynamic team to enhance large-scale telecommunications solutions, ensuring operational excellence and safety while driving continuous improvement a...

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $240K *

Deliver high-quality fullstack web solutions, owning major product features from design to launch while collaborating with cross-functional teams to enhance platform reliability and performance...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $260K *

Join Reddit's Ads team as a Machine Learning Engineer, where you will design, build, and deploy machine learning models to enhance ad ranking, bidding, and optimization. This hands-on role involves ta...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Media

$170K - $205K *

Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$139K - $285K *

Drive the analytics engineering team to create AI-ready data solutions, ensuring trusted access to data across the organization. Lead strategic initiatives, build self-service capabilities, and foster...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.