Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$230K - $290K *

Lead the charge in optimizing ad performance through innovative algorithms and machine learning. Collaborate with cross-functional teams to enhance advertising effectiveness and drive business success...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$170K - $222K *

Drive strategic transformation initiatives across Product, GTM, and Operations. Lead cross-functional teams, manage complex portfolios, and deliver measurable results while fostering clarity and accou...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $159K *

Empower the future of medical technology by ensuring the highest quality in embedded systems. Collaborate with cross-functional teams to drive compliance and innovation in software development for lif...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a team that's redefining mental health technology by developing a cutting-edge brain stimulator platform. Lead fullstack development, enhance user experience, and mentor a talented engineering te...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $173K *

Drive integration strategies to enhance silicon photonic fabrication, collaborating with foundries to evolve processes from development to production while ensuring robust performance and reproducibil...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Lead the design and development of complex software systems, ensuring architectural consistency and best practices. Collaborate with teams to deliver scalable solutions while mentoring engineers and d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Accelerate your career by designing and optimizing secure, scalable cloud infrastructure. Collaborate with cross-functional teams to enhance operational efficiency and ensure high availability for glo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$225K - $281K *

Shape the future of application security by leading strategy and initiatives across teams. Drive secure design and standards, mentor engineers, and tackle complex security challenges in a collaborativ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Drive quality assurance as a Senior QA Automation Engineer, enhancing our distributed database platform through designing automated tests, validating features, and improving release processes while wo...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the evolution of our design system by building foundational infrastructure that empowers designers, engineers, and AI agents to create cohesive, high-quality experiences while leading a growing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$198K - $233K *

Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $194K *

Lead the development of fullstack features for subscription management, enhancing customer experiences and ensuring reliable billing workflows. Collaborate with cross-functional teams to deliver safe...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Join a team that's shaping the future of platform engineering, driving innovation across cloud, DevOps, and site reliability. This role empowers you to build core services, enhance architecture, and m...

RemoteRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$106K - $284K *

Drive innovative software development strategies while leading cross-functional teams to deliver high-quality solutions. Foster collaboration, mentor talent, and manage project timelines to achieve or...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $260K *

Lead a high-performing team to architect innovative AI solutions that empower business transformation. Drive AI initiatives from ideation to deployment while fostering collaboration across functions f...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Transform user experiences by building and enhancing robust software solutions across frontend and backend layers, focusing on customer-facing AI products to ensure quality and safety in delivery...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$190K - $210K *

Explore innovative solutions as you lead the design and architecture of scalable healthcare applications, mentor engineers, and collaborate with cross-functional teams to enhance patient experiences a...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Unlock potential by leading mobile app development, shaping user experiences, and driving technical direction in a fast-paced environment. Collaborate with cross-functional teams to deliver intuitive...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Lead the charge in driving program delivery and portfolio management for a dynamic Security team, ensuring effective execution of enterprise initiatives while fostering cross-functional collaboration...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$68K - $131K *

Optimize cutting-edge cybersecurity solutions by leading innovative research and development efforts. Collaborate with multidisciplinary teams to tackle complex challenges in embedded systems and comm...

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Transform software solutions by leading architecture and design efforts, mentoring teams, and driving modernization initiatives. Collaborate across divisions to enhance public services while ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the technical design and delivery of innovative AI agent solutions, leading a team to ensure operational readiness and quality. Collaborate with stakeholders to define requirements and guide eng...

RemoteRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join a dynamic team to drive technical vision and operational excellence in cloud-native platforms. Lead engineering efforts, champion security practices, and empower talent while ensuring system stab...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$222K - $314K *

Drive innovation by designing and implementing LLM-based systems that tackle complex problems in data processing, empowering the team with your technical direction and expertise while overseeing impac...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $205K *

Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.