Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$125K - $150K *

Advance your career by building high-throughput services that power AI workflows. Collaborate with cross-functional teams to design scalable infrastructure and tackle complex challenges in a dynamic e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $135K *

Lead the charge in developing high-quality software solutions, mentoring engineers, and driving process improvements. Collaborate with stakeholders to enhance systems and deliver impactful results in...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$86K - $130K *

Contribute to the development of embedded software within a global team, focusing on tractor drive strategy and testing systems to ensure vehicle performance, efficiency, and productivity in high-visi...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $175K *

Shape the cloud infrastructure landscape by ensuring security, scalability, and efficiency. Collaborate with engineers to build resilient systems and drive best practices, enabling smooth deployment a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$156K - $275K *

Transform machine learning infrastructure by deploying scalable models, building pipelines, and ensuring model health across product and marketing workflows. Collaborate with data scientists and engin...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Champion modernization initiatives by designing and overseeing transformation solutions, integrating cutting-edge GenAI technology, and ensuring alignment with business objectives to drive impactful m...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Transform business challenges into innovative solutions by leveraging AI and engineering expertise. Collaborate with stakeholders to identify opportunities, develop full-stack applications, and drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $135K *

Join a team that's shaping the future of data management by guiding strategic direction and execution for B2G registration and reporting platforms. Collaborate across technical and business domains to...

Iowa City, IARemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $135K *

Lead the charge in shaping data management strategies and solutions for B2G registration and reporting platforms. Collaborate across teams to enhance automated tools and ensure compliance, driving inn...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$200K - $250K *

Transform your career by leading cross-functional R&D initiatives that enhance platform security and modernization. Drive impactful engineering decisions while mentoring a team of Staff Engineers to a...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$200K - $250K *

Optimize your career as a full-stack software engineer, collaborating with agile teams to enhance high-transaction e-commerce applications. Drive quality, mentor peers, and innovate solutions that ele...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

Contribute to the development of innovative web applications using .Net, Angular, and SQL. Collaborate with a dynamic team to enhance existing systems and design new solutions, ensuring high-quality s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$223K - $290K *

Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $165K *

Unlock potential by harnessing your expertise as a Senior .NET Developer, driving the evolution of high-availability applications in a cloud-native environment, leading projects, mentoring teams, and...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$250K - $300K *

Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$130K - $155K *

Unlock your potential by owning the technical design of a comprehensive data platform. Collaborate with cross-functional teams to deliver trustworthy data solutions that enhance product performance an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $140K *

Unlock your potential as a Forward Deployed Engineer, bridging AI solutions with enterprise needs. Collaborate closely with clients to architect and implement robust systems, ensuring real-world appli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$97K - $139K *

Join a dynamic team to develop full-stack applications that enhance user engagement and drive growth on a global scale, leveraging data and AI to create impactful features for millions of Quora users...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $339K *

Transform programmatic advertising by defining and scaling innovative products, collaborating across teams to enhance advertiser experiences while ensuring alignment with strategic business goals...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$154K - $212K *

Lead the charge in engineering excellence across device product areas, managing teams and driving innovation in patient engagement technology. Collaborate closely with cross-functional teams while mai...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $222K *

Drive strategic transformation initiatives across Product, GTM, and Operations. Lead cross-functional teams, manage complex portfolios, and deliver measurable results while fostering clarity and accou...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.