Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$100K - $140K *

Lead the charge in architecting and building intelligent systems for autonomous GRC workflows, leveraging C#/.NET and Blazor to create scalable, high-performance solutions that drive innovation and ef...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion the security of our AI supercomputer infrastructure, ensuring robust controls and isolation for customer workloads. Collaborate with cross-functional teams to design, implement, and maintain...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$120K - $150K *

Unlock potential by leading software engineering initiatives, mentoring junior engineers, and driving improvements in development processes. Collaborate with stakeholders to deliver impactful solution...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $250K *

Unlock potential by owning a product area end-to-end, collaborating with engineering and customers to drive innovation and deliver impactful solutions in a dynamic market...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Accelerate progress at the forefront of dental technology by leading software development for specialized machines, shaping the future of custom prosthetics manufacturing in a dynamic, high-growth env...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$199K - $334K *

Champion the architecture and engineering of agent memory systems, leading the development of context-driven AI agents. Drive innovation and technical direction while collaborating across teams to enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $145K *

Unlock your potential by designing CI/CD pipelines and automating processes. Collaborate with teams to enhance development efficiency while ensuring system compliance and security across AWS and Azure...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Innovate healthcare delivery by developing AI solutions that enhance operations and resident experiences. Collaborate with teams to automate processes and improve clinical decision-making in senior ca...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $284K *

Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $127K *

Transform software solutions by developing, analyzing, and optimizing applications. Collaborate with teams to enhance operational efficiency and deliver innovative technology for diverse industries in...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$155K - $175K *

Empower engineering teams by leading the evolution of cloud, security, and AI operations. Drive platform reliability and DevSecOps practices while mentoring others to foster a collaborative, innovativ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$138K - $203K *

Empower the future of scalable email systems by developing and managing high-performance backend services. Collaborate with cross-functional teams to enhance cloud infrastructure and optimize microser...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Transportation

$177K - $265K *

Lead security initiatives to enhance application security across the SDLC. Collaborate with cross-functional teams to embed security practices, conduct threat modeling, and mentor engineers, ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$206K - $242K *

Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $176K *

Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$87K - $230K *

Partner with us to lead transformative workplace technology solutions, driving secure, scalable implementations across enterprise environments while enhancing employee experiences through collaboratio...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$174K - $209K *

Drive innovation by enhancing backend systems and APIs for billing and usage calculations. Collaborate with cross-functional teams to improve reliability and efficiency, ensuring seamless customer exp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$279K - $349K *

Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by designing and developing scalable cloud-native applications. Leverage your expertise in Java, Spring Boot, React, and Node.js to enhance Workforce Management and Customer Experi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of cloud-native applications by designing and developing scalable solutions that enhance Workforce Management and Customer Experience. Collaborate with cross-functional teams to deliv...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $154K *

Explore a dynamic role in cyber network operations, developing tools that support national security missions. Collaborate with a skilled team to enhance software capabilities and contribute to critica...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$210K - $273K *

Drive the evolution of a robust online ML inference platform, enhancing model deployment, performance, and safety in high-traffic environments by collaborating with cross-functional teams and spearhea...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$204K - $290K *

Manage the Resilience Engineering team to enhance system reliability through production load testing and chaos engineering while fostering a proactive safety culture across engineering practices...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.