Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

$141K - $177K *

Join us to shape the future of cybersecurity by leading product vision and strategy for our innovative Autonomous and Continuous pentesting platform, driving impactful solutions that enhance security...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$200K - $275K *

Transform your career by owning the design and delivery of impactful features, collaborating with cross-functional teams to craft innovative software solutions that enhance user experiences and drive...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$225K - $265K *

Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $120K *

Optimize the software development process by contributing to product-focused projects, addressing coding, debugging, automated testing, and performance enhancement to ensure scalable and efficient sof...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $120K *

Unlock innovation as a hands-on Software Engineer, driving Proofs-of-Concept and full software development cycles. Collaborate with senior engineers to explore emerging technologies while ensuring pro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape the future of quality assurance by leading automated testing initiatives for cloud-based ERP systems, ensuring seamless integration and performance across various business processes and upgrades...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive innovation by building AI-first SaaS products, leading agentic development, and ensuring high-quality software delivery through collaborative engineering practices and robust CI/CD pipelines...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$218K - $256K *

Lead the charge in architecting scalable payment systems that process billions in transactions. Collaborate cross-functionally to ensure reliability and compliance while mentoring engineers to elevate...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$127K - $213K *

Transform integration solutions by designing and developing robust MuleSoft applications. Collaborate with cross-functional teams to ensure high-quality delivery and optimize performance while mentori...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's shaping the future of embedded systems and simulation technologies. Collaborate globally to tackle complex technical challenges, enhance product reliability, and support innovative...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$120K - $130K *

Join a team that's building a robust data platform to transform health data into actionable insights. Collaborate on backend services and data systems, enhancing reliability and performance while driv...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $168K *

Join a team that's transforming operational data into reliable customer experiences. As a Senior Machine Learning Engineer, you'll lead the development of innovative machine learning solutions, enhanc...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$250K - $400K *

Shape the future of AI by partnering with customers to design and deliver innovative data solutions. Collaborate with a senior team to tackle complex challenges and transform vague requests into actio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Innovate AI-driven business applications by designing Python services and APIs that enhance data processing capabilities in both cloud and on-premises settings, ensuring robust performance and seamles...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Technical Services

$200K - $270K *

Join a team pioneering AI/ML platform engineering, enhancing scalable infrastructure to empower scientific innovation. Shape the future of distributed systems and MLOps, collaborating across teams to...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$173K - $233K *

Lead the charge in developing high-availability backend systems, collaborating with cross-functional teams to deliver impactful solutions while fostering a culture of quality and ownership within your...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Empower teams by designing and delivering automation solutions that streamline workflows, enhance operational efficiency, and support scalable applications across hybrid cloud environments. Join us in...

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$152K - $190K *

Unlock potential by leading the design and development of innovative software solutions, guiding a team of engineers to enhance clinical laboratory processes and ensure seamless integration of systems...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$166K - $193K *

Lead and mentor a team of engineers while overseeing technical excellence and driving AI innovation in operational systems. Collaborate cross-functionally to deliver impactful features for post-purcha...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $100K *

Lead the charge in enhancing embedded software development through robust CI/CD pipelines, automation, and collaboration with cross-functional teams to streamline processes and improve productivity...

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$86K - $165K *

Join a team that's developing cutting-edge embedded software for advanced avionics systems. Contribute to platform control, security, and diagnostics while collaborating with cross-functional teams to...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$185K - $250K *

Join a team that's committed to building innovative software solutions that enhance user experience and streamline development processes while collaborating with top-tier engineers to deliver impactfu...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$130K - $170K *

Accelerate progress at the forefront of real-time media ingestion, designing and operating distributed services that enhance communication data processing for analytics and security. Lead projects and...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $225K *

Drive the design and delivery of innovative AI-driven applications. Oversee the full development lifecycle, ensuring scalability and reliability in multi-tenant enterprise solutions while collaboratin...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.