Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$110K - $130K *

Pioneer innovative solutions by partnering with customers and teams to transform AI and HPC requirements into reliable deployments, driving success through technical depth and collaboration across fun...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$123K - $202K *

Innovate advanced GIS and remote sensing software for defense and intelligence, collaborating with a skilled team to enhance analytical workflows and imagery processing capabilities, while mentoring j...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Champion mobile innovation by owning the ElevenMusic app across iOS and Android. Drive product development with autonomy, focusing on creating exceptional experiences for musicians and creatives in a...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$143K - $238K *

Shape the future of embedded flight software by designing robust solutions for real-time operating systems. Collaborate with cross-functional teams to develop, document, and maintain critical systems...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$110K - $130K *

Lead the charge in developing a sophisticated healthcare SaaS platform by designing, implementing, and maintaining full-stack features that enhance user experience and system performance in a dynamic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Innovate and implement robust disaster recovery solutions for enterprise DevOps, ensuring critical infrastructure recoverability. Oversee Jenkins, Bitbucket, and JFrog Artifactory environments while e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Transform complex Naval engineering records into actionable AI solutions. As a Senior Platform Engineer, you'll lead platform engineering efforts, ensuring seamless application deployment and operatio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$238K - $280K *

Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$146K - $225K *

Grow your career with a collaborative team focused on building backend systems for identity validation, ensuring compliance, and supporting all products. Contribute to transparent financial solutions...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $150K *

Lead the charge in integrating complex hospital data systems into Astra OS. Own end-to-end data pipelines, collaborate with customers, and design scalable solutions that enhance healthcare operations...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by owning the end-to-end product surface, driving discovery, design, and migration while collaborating closely with users to solve real market problems in a dynamic healthcare environ...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $130K *

Champion the enablement engine for Cloud Compute and GPU products, transforming complex technical capabilities into actionable training and tools for sales teams, ensuring alignment with product relea...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Optimize and implement scalable, secure infrastructure solutions across Windows, Citrix, AWS, and Azure. Drive automation and collaborate with teams to design zero-trust architectures, enhancing infra...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Unlock potential by joining our dynamic team as a mid-level full-stack software developer. Contribute to innovative solutions for the U.S. Navy Reserve, collaborating with experts in an Agile environm...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $252K *

Join a team that's transforming federal HR systems by engineering integration solutions between Oracle Fusion Cloud HCM and key federal platforms to drive modernization efforts across multiple agencie...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$145K - $165K *

Join a dynamic team as a Data Engineer, driving data-driven decisions by designing and implementing innovative data solutions. Collaborate with stakeholders to enhance data accessibility and support a...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$206K - $242K *

Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $157K *

Drive your career forward by leading complex software projects, collaborating with diverse teams, and leveraging cutting-edge technologies to deliver high-quality solutions that meet client needs and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Innovate in mission planning by developing autonomous operations for satellite constellations. Collaborate with cross-functional teams to define requirements, prototype code, and optimize algorithms...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $150K *

Lead the charge in enhancing infrastructure reliability and automation for large-scale game development projects, collaborating with teams to implement cloud solutions and streamline CI/CD processes...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$90K - $110K *

Transform customer engagement by delivering tailored product demonstrations, guiding technical discussions, and architecting solutions that meet unique educational needs across diverse sectors...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's redefining B2B product design by optimizing user experiences across diverse workflows, integrating AI-powered features, and creating impactful solutions for multiple user types. You...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $200K *

Champion robust backend architecture and distributed systems, guiding technical direction and establishing best practices. Collaborate across teams to build resilient, scalable applications and optimi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$200K - $322K *

Lead the charge in driving open source adoption and governance. Manage community infrastructure, contributor pathways, and post-launch plans to ensure sustainable project growth and engagement across...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the charge in evolving our AI systems by developing innovative agentic software tools, ensuring performance and reliability while collaborating with AI agents to transform code delivery into a se...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.