Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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$212K - $265K *

Advance your career by leading the design of scalable insurance systems, collaborating with cross-functional teams to enhance product offerings and drive technical excellence in a dynamic environment...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$90K - $110K *

Optimize software delivery by developing and maintaining CI/CD pipelines, automating deployment processes, and enhancing system reliability. Collaborate with teams to streamline operations and support...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $160K *

Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$220K - $290K *

Accelerate the development of autonomous systems by leading systems engineering strategies, aligning cross-functional teams, and ensuring rigorous safety and performance standards throughout the produ...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$91K - $118K *

Accelerate your career by driving technical solutions and proposals for engineered equipment. Collaborate with sales and engineering teams to ensure customer satisfaction and secure new business oppor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$113K - $140K *

Champion the reliability and performance of critical systems, driving architecture evolution and incident response. Collaborate with a skilled team across AWS and Azure, ensuring security and scalabil...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $135K *

Shape the future of IoT solutions by leading backend cloud services development. Drive technical design, mentor engineers, and ensure scalable architecture for AWS-based applications while enhancing u...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$87K - $209K *

Join a dynamic team to design and implement backend services, enhancing developer tooling and integration frameworks. Drive improvements in performance and resilience while collaborating with cross-fu...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by designing and implementing enterprise identity solutions, ensuring secure access across cloud and hybrid environments while collaborating with cross-functional teams to enhance IAM...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$168K - $181K *

Lead the charge in developing innovative AWS cloud solutions for scoring capabilities. Collaborate with cross-functional teams to enhance system reliability and efficiency, while mentoring junior engi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$224K - $431K *

Innovate cutting-edge software for data center power management, spanning architecture, firmware, and AI workloads. Drive product lifecycle from design to deployment, enhancing performance and energy...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$217K - $303K *

Innovate with us to lead a high-performing engineering team, shaping a scalable AI-powered knowledge graph platform that enhances data quality and drives impactful user experiences across multiple app...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$150K - $180K *

Lead and inspire a blended team of developers to enhance AI-driven legal automation platforms, ensuring technical excellence, delivery, and collaboration across functions while managing architecture...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Develop and optimize a scalable, geo-distributed database solution while leading a skilled team. Engage in deep technical challenges to enhance performance and reliability across diverse environments...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$156K - $281K *

Join a team that's redefining structural engineering for data centers. As a Senior Principal Structural Engineer, you'll ensure the integrity of innovative designs, collaborating across disciplines to...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Consumer Technology

$110K - $130K *

Champion the future of mental healthcare by architecting innovative solutions for Provider Onboarding. Lead a dynamic team to enhance tools and workflows, ensuring seamless integration for users while...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $140K *

Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Champion user experience by enhancing our insurance platform's web interface. Collaborate with teams to simplify design, implement UX initiatives, and develop solutions that empower agents and interna...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Champion seamless technical integrations by leading end-to-end delivery, troubleshooting, and documentation. Collaborate with customer IT teams to ensure compliance and optimize data flows in a dynami...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$185K - $230K *

Unlock your potential as a Senior Machine Learning Engineer, driving innovative AI solutions and enhancing performance across complex workflows. Collaborate with diverse teams to shape the future of A...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$250K - $400K *

Shape the future of AI by designing evaluation frameworks and feedback systems that enhance model performance. Collaborate across teams to translate research into scalable solutions, driving impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $165K *

Lead the charge in enhancing marketing technology platforms to optimize customer engagement and journey orchestration. Collaborate with cross-functional teams to deliver reliable solutions and improve...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $102K *

Unlock potential by leading the development of LLM-powered applications and agentic systems. Collaborate across teams to design, implement, and maintain innovative software solutions, ensuring high qu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.