Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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$110K - $130K *

Join a dynamic team in developing advanced robotic solutions, leading software design and architecture while mentoring others. Play a crucial role in motion planning, perception tasks, and ensuring hi...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$134K - $241K *

Shape the future of product quality by leading a dedicated team, enhancing testing processes, and driving product excellence through comprehensive strategies and cross-functional collaboration...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$78K - $121K *

Empower stakeholders through effective management of consultant compliance, invoicing, and event logistics. Ensure meticulous record-keeping, uphold process adherence, and enhance operational efficien...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $196K *

Join a team that's shaping schedule strategies for major industrial and federal projects. Leverage your expertise in complex schedule management to drive project success and collaborate with multi-par...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$160K - $185K *

Innovate quality assurance in a fast-paced environment by spearheading testing across backend services, APIs, and customer applications to elevate reliability and performance with advanced automation...

US-AnywhereRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $213K *

Join a team that's transforming People systems with AI-driven automation. As a key engineer, you'll design, build, and maintain integrations and workflows that enhance efficiency across HR platforms...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$107K - $195K *

Transform data into actionable insights by leading a strategy for real-time visibility in complex environments. Collaborate across teams to design and implement visual analytics solutions that enhance...

US-AnywhereRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$175K - $210K *

Pioneer advancements in oncology by leading global product development for late-stage radiopharmaceuticals. Collaborate across functions to meet objectives, manage risks, and ensure regulatory complia...

US-AnywhereRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Manage clinical trials to ensure compliance, timelines, and budgets while overseeing CROs and vendors. Be key in driving project success and maintaining data integrity and participant safety throughou...

US-AnywhereRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform client challenges into innovative solutions by leveraging tech expertise and collaborative skills to drive progress and enhance team dynamics, ensuring ongoing success and high performance i...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$105K - $231K *

Unlock innovation by joining a team developing transformative AI solutions. Collaborate with experts in a high-impact environment, focusing on building and deploying cutting-edge web applications and...

US-AnywhereRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$122K - $159K *

Drive successful infrastructure delivery initiatives across hybrid environments, balancing demand and capacity. Collaborate with engineering and business stakeholders to ensure alignment on strategic...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Transportation

$130K - $155K *

Lead the charge in creating cutting-edge embedded software solutions for autonomous mobile robotics. Drive technical excellence, oversee collaborative engineering efforts, and ensure high reliability...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$106K - $160K *

Shape the future of Global Supply Chain Compliance by leading audits, providing expertise, and ensuring adherence to regulatory standards while collaborating across all organizational levels with a fo...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$116K - $145K *

Transform our application security landscape by independently managing vulnerabilities, integrating security into development pipelines, and enabling teams to deliver secure code with efficiency and c...

US-AnywhereRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$132K - $220K *

Lead the charge in comprehensive project management for nuclear industry initiatives. Drive profit and loss accountability while ensuring high customer satisfaction through effective coordination, ris...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$220K - $240K *

Lead the charge in optimizing healthcare operations using AI technology. Shape architectural decisions and collaborate with engineering teams to develop scalable backend services, improving member exp...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Accelerate progress at federal agencies by delivering AI solutions that ensure compliance, security, and mission outcomes. Collaborate with sales teams to demonstrate value and guide clients through s...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$126K - $227K *

Join a dynamic team as you oversee the execution of enterprise-level growth programs, ensuring timely site launches and operational readiness while applying PMI standards across cross-functional teams...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$144K - $175K *

Help us redefine marketing through AI-driven automation, building a strong data foundation. Collaborate with leadership to create powerful workflows and elite marketing solutions that challenge the no...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$145K - $222K *

Optimize nuclear power plant systems design by leading modification projects, preparing technical documents, and collaborating with clients to ensure smooth operations and compliance with industry sta...

US-AnywhereRemote

2 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$170K - $230K *

Join a dynamic team to shape product and infrastructure security. As a core engineer, you'll develop automated security solutions and collaborate closely with engineering to maintain high-speed innova...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Empower success by serving as a business-technical advisor, guiding customers through complex software solutions while ensuring seamless integration and operational alignment with the Theatro platform...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $170K *

Lead the charge in building a robust data engineering team while architecting and managing a scalable data platform. Balance hands-on engineering with strategic leadership to drive data initiatives th...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $149K *

Shape the future of AI solutions by bridging technology and customer success through hands-on engineering design, implementation, and support within the OneStream ecosystem, ensuring reliability and s...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.