Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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$157K - $184K *

Join a pioneering team dedicated to securing software supply chains and cloud-native environments. Leverage your technical expertise in CI/CD, Kubernetes, and industry security frameworks to drive inn...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $300K *

Join a team that's shaping technological innovation and strategy across the enterprise. You will collaborate with senior leaders, mentor engineers, and advance the adoption of cutting-edge technologie...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$149K - $185K *

Transform customer engagement through strategic field marketing. Lead event planning and execution for impactful customer programs, driving measurable outcomes and fostering cross-functional collabora...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Launch your career as a Portfolio Analyst supporting high-impact government travel operations. Drive efficiencies, ensure regulatory compliance, and enhance program management while collaborating with...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $160K *

Join a team that's building innovative AI solutions to transform healthcare, focusing on designing a Drug/Drug Interaction Smart Connector using LangChain and LangGraph while ensuring data accuracy an...

US-AnywhereRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$219K - $285K *

Innovate digital strategies in R&D to enhance efficiency and value creation. Collaborate with cross-functional teams, drive operational excellence, and establish a culture of continuous improvement fo...

US-AnywhereRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Deliver cross-functional leadership and strategic direction for internal tools and platforms, enhancing user experiences and operational workflows. Guide product visions and implement solutions for sc...

US-AnywhereRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $120K *

Join us as a Program Manager to drive cross-program coordination and enhance customer engagement in federal supply chain initiatives. Leverage your expertise to foster relationships and oversee projec...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Engineer innovative data solutions while leading digital transformation projects. Collaborate with cross-functional teams to develop scalable data architectures and ensure data quality, driving insigh...

US-AnywhereRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$90K - $100K *

Join a team that champions public safety through innovative technology solutions. As a key player, you'll manage and support Records Management Systems, fostering vital relationships while enhancing o...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$142K - $152K *

Join a dynamic team to deliver complex projects that support enterprise IT strategy. Utilize advanced methodologies to manage risks and achieve high-quality outcomes while leading multiple teams in a...

US-AnywhereRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$92K - $120K *

Engineer innovative geostructural solutions while leading the design and inspection processes for complex construction projects in NYC, balancing technical excellence with client-focused strategies an...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $130K *

Drive the delivery of innovative cloud solutions, optimizing scalability and performance for complex enterprise environments. Collaborate with a dedicated team to architect, manage, and support robust...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $130K *

Shape innovative solutions as you provide expert technical support for OEM customers in PCB design and manufacturing. Collaborate across teams to drive advanced design activities and improve communica...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$99K - $172K *

Transform the efficiency and effectiveness of operations through versatile support in strategy execution, data analysis, and process automation. Engage across all pillars, ensuring leadership is empow...

US-AnywhereRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$99K - $166K *

Optimize talent acquisition strategies to drive commercial growth. Lead full-cycle recruiting for senior roles in Sales, Marketing, and Business Development. Foster strong stakeholder partnerships and...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Staffing

$70K - $95K *

Unlock potential by generating precise SaaS pricing proposals and quotes, enhancing sales efficiency. Collaborate closely with teams to drive successful deal execution and improve quoting processes in...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $120K *

Lead manufacturing capacity analysis and capital equipment projects to enhance operational performance and meet customer demand. Collaborate with cross-functional teams and manage equipment readiness...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $174K *

Contribute to product vision and strategy by collaborating with cross-functional teams to deliver solutions that align with business goals, fostering a culture of Agile excellence and driving the life...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$185K *

Lead transformative sales initiatives as a Senior CoreValve District Manager, driving strategy and growth for the Medtronic CoreValve System. Cultivate high-performing teams and sustainable business r...

US-AnywhereRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $130K *

Pioneer AI-driven product strategies, leading cross-functional teams to innovate and enhance the software development lifecycle. You'll collaborate with engineering, data science, and market experts t...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $180K *

Shape the future of managed services by leveraging AI-driven solutions, optimizing complex processes, and collaborating with cross-functional teams to deliver client-focused application support and de...

US-AnywhereRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$96K - $161K *

Transform critical applications to enhance business processes by collaborating with teams, analyzing technical needs, and providing guidance. Drive improvements and mentor peers while ensuring quality...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$237K - $264K *

Shape and lead a team of Sales Engineers, driving technical support and customer engagements in pre-sales cycles. Cultivate strong collaborations, ensuring effective adoption of data security solution...

US-AnywhereRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $110K *

Drive multiple large-scale telecommunications projects, ensuring operational success, risk management, and budget oversight while maintaining customer satisfaction and fostering effective relationship...

US-AnywhereRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.