Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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$120K - $140K *

Optimize the deployment of agentic AI solutions, directly engaging with clients to turn AI capabilities into integrated production systems while ensuring strong ROI through effective technical advisor...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$175K - $225K *

Drive AI innovation for financial advisors by defining product strategy and leading development from concept to launch. Collaborate closely with teams to ensure alignment and enhance advisor efficienc...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $178K *

Pioneer a comprehensive Computer System Validation strategy across GxP systems. Collaborate with Quality and IT to drive compliance and data integrity while enhancing efficiency in validation processe...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate operational efficiency by leading design and implementation of advanced warehouse systems, encompassing layout, material handling, and automation workflows to optimize logistics and enhance pr...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Unlock potential by leading warehouse design projects, managing engineering activities, and collaborating with teams to optimize material flow and layouts for enhanced efficiency. Ensure successful im...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's driving the efficient execution of product roadmaps through impactful coordination across Data Products & Analytics and Engineering. Lead by establishing epic quality and enhancing...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $130K *

Partner with us to engineer secure, resilient infrastructure across cloud-native and edge environments. You'll ensure operational excellence, mitigate risks, and enhance deployment practices while col...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $207K *

Join a team that's dedicated to designing and optimizing resilient infrastructure platforms supporting critical applications. Collaborate closely with cross-functional teams to enhance performance, re...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a dynamic team to oversee and optimize multi-state tax incentive strategies, driving operational efficiencies and fostering collaboration across departments to support strategic growth and compli...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$115K - $155K *

Transform the customer onboarding experience in local government with engineer-led implementations. Collaborate on technical challenges, automate key processes, and ensure data integrity while buildin...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$83K - $160K *

Lead the charge in managing multiple projects for insurance clients, ensuring timely delivery and quality engagement. Collaborate across teams, report on progress, and drive best practices while mento...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Empower the future of radiation oncology software by leading the design, development, and maintenance of cutting-edge .NET applications, collaborating closely with remote engineering teams to enhance...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $240K *

Unlock potential by leading the evolution of cybersecurity architecture for a secure enterprise. Drive innovation while ensuring compliance with federal regulations and aligning with Zero Trust princi...

US-AnywhereRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Transform healthcare technology by leading an internal engineering team. Oversee the transition of software ownership, manage vendor relationships, and drive AI strategy ensuring patient data privacy...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Unlock your potential as a key contributor in developing innovative, data-driven software solutions for biopharmaceutical processes, enhancing digital transformation efforts through cutting-edge techn...

US-AnywhereRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Oversee the comprehensive management of the West Region Infrastructure LMR System, ensuring operational excellence, budget adherence, and proactive collaboration with cross-functional teams to meet Do...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$135K - $160K *

Lead the design and implementation of high-volume transaction systems, focusing on wallet and lifecycle management, cross-chain integrations, and end-to-end engineering, ensuring high reliability and...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$152K - $205K *

Pioneer the development of scalable microservices and AI-enabled tooling, enhancing software delivery experiences. Collaborate with teams to design resilient systems and monitor operational excellence...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $210K *

Transform the architecture of data solutions for a leading data platform. Collaborate with product and engineering teams to enhance data models, ensure integrity, and coach stakeholders across the org...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $100K *

Join a team that's shaping the future of healthcare data integration. Lead the technical aspects of client Epic data acquisition, ensuring seamless extraction and delivery of critical information whil...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $160K *

Lead the charge in driving operational excellence and transformation by translating business needs into actionable requirements, managing delivery workflows, and enhancing the Revenue Intelligence por...

US-AnywhereRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$143K - $273K *

Pioneer the next wave of enterprise AI transformation by leading full-stack engineering teams to create innovative software solutions, integrating advanced language models, and delivering tangible bus...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Empower a dynamic team to lead analytical and programmatic support for key digital health initiatives within federal health agencies. Drive project success through data analysis, stakeholder engagemen...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $210K *

Champion the AI-first transformation of customer-facing SaaS products by leading engineering excellence and delivering scalable solutions. Guide a globally distributed team while collaborating cross-f...

US-AnywhereRemote

2 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$185K - $273K *

Transform cutting-edge IoT platforms by designing, developing, and testing complex software features. Collaborate with agile teams to enhance technology and innovate modular solutions for next-generat...

US-AnywhereRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.