Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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1
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$135K - $160K *

Join a dynamic team to optimize software development through AI-driven automation, resolving key pain points and enhancing efficiency in core workflows, while enjoying the flexibility and autonomy of...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$280K - $340K *

Lead, inspire, and develop a high-performing Solutions Architecture team, driving enterprise customer acquisition for a cloud platform. Foster strategic partnerships, ensure technical excellence, and...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the development of critical backend systems that enhance case execution workflows, focusing on eligibility and batching, while collaborating across teams to ensure data accuracy and system reliab...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$123K - $132K *

Take ownership of enhancing in-house tools, investigating performance issues, and optimizing enterprise systems while collaborating with cross-functional teams to ensure scalability and reliability of...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$121K - $225K *

Join us to design and implement scalable technical solutions, guiding enterprise transformations through collaboration and clear communication at all levels of organization, ensuring quality and adher...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $160K *

Join us to enhance our DevSecOps practice by developing robust APIs and integration solutions that connect services and systems, driving efficiency and effectiveness for our clients' missions...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$188K - $250K *

Help us redefine AI integration by leading engineering teams to build innovative AI systems and standards, fostering a culture of collaboration and technical excellence in a high-impact role that shap...

US-AnywhereRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$98K - $143K *

Grow your career with this critical Sr. Financial Analyst role supporting enterprise-wide financial clarity and forecasts. Collaborate with cross-functional teams to enhance data integrity and drive i...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $244K *

Elevate operational efficiency by leading cross-functional programs, enhancing product delivery and aligning teams. Drive execution strategies, implement robust processes, and ensure project success a...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Join us to elevate quality standards in radiopharmaceutical development. Lead GMP compliance and quality systems while mentoring junior staff. Drive improvement across our portfolio, ensuring regulato...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$141K - $185K *

Transform enterprise-level programs across industries, leading a dynamic team to drive digital transformation. Leverage PTC technologies as a strategic advisor, ensuring project excellence and stakeho...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$128K - $176K *

Play a key role in designing and maintaining cloud infrastructure, optimizing developer experiences, and ensuring operational excellence in a fast-paced environment. Collaborate across teams to enhanc...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Engage customers as a key technical partner for GPU infrastructure, ensuring successful deployment, performance optimization, and resolution of complex issues, while collaborating across teams to enha...

US-AnywhereRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $140K *

Join a team that's defining quality engineering excellence. Champion test automation, enhance quality standards, and mentor QA professionals while overseeing strategic test initiatives for reliable pr...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$58K - $121K *

Join a team that provides strategic guidance and oversight to optimize human performance and well-being for Special Operations Forces personnel and their families, ensuring compliance and advancing he...

US-AnywhereRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$168K - $322K *

Join a team that's building robust AI systems by leading multi-functional programs across model training, evaluation, and infrastructure. Collaborate with experts to drive software development that el...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$153K - $170K *

Join a dynamic team as you lead engineering excellence and growth, driving product innovation while mentoring talent. Balance hands-on technical leadership with overseeing project milestones and foste...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Drive compliance excellence as the key owner of proposal governance across high-stakes federal pursuits. Lead oversight efforts, enforce standards, and ensure submission readiness to prevent disqualif...

US-AnywhereRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Join a team that's driving innovation in oncology by managing projects to advance approved imaging agents and late-stage products, enhancing lives through strategic planning, execution, and collaborat...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$107K - $159K *

Shape the future by serving as a strategic partner, translating complex needs into actionable solutions while leading and mentoring a team to foster collaboration between business and IT, driving effi...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$167K - $278K *

Pioneer the AI platform architecture and strategy for scalable, production-ready solutions, enhancing innovation and operational excellence while fostering cross-functional integration and governance...

US-AnywhereRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$117K - $145K *

Unlock your potential as a Senior Enterprise Technical Support Engineer, leveraging 8+ years of expertise in troubleshooting complex cloud and infrastructure challenges while mentoring a dynamic team...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $250K *

Drive cross-functional collaboration to manage embedded software programs, ensuring alignment between hardware and software teams. Oversee planning, execution, and risk management for various program...

US-AnywhereRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$184K - $287K *

Join a team that's transforming materials science and chemistry through AI and accelerated computing. As a key technical advisor, you'll enhance workflows and drive innovations that shape next-generat...

US-AnywhereRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$160K - $185K *

Elevate your career by collaborating with sales teams to showcase Cresta's AI-driven solutions. You'll provide technical insights, conduct demos, and drive adoption while translating client needs into...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.