Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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$150K - $200K *

Transform enterprise strategy by leading high-impact initiatives across business functions. Collaborate with executives to enhance organizational effectiveness and drive measurable business outcomes f...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Champion project execution as a skilled leader in utility engineering, driving planning, stakeholder collaboration, and financial management while fostering innovative solutions to enhance client sati...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$140K - $228K *

Lead the development of user-centered front-end applications using modern technologies. Collaborate with cross-functional teams to drive features from concept to release, ensuring high-quality and sca...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$83K - $222K *

Elevate your career by designing and maintaining healthcare integrations, ensuring efficient data exchange between systems while guiding projects and mentoring peers in a fast-paced, impactful environ...

US-AnywhereRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$195K - $290K *

Drive the design and deployment of cutting-edge data platforms for AI-driven security solutions. Lead a team in optimizing large-scale systems, focusing on LLM integration and agile delivery while ens...

US-AnywhereRemote

1 month ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $180K *

Optimize complex Microsoft solutions by leading client engagements, crafting proposals, and designing innovative architectures. Collaborate with technical teams to deliver cutting-edge projects, ensur...

US-AnywhereRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $140K *

Empower a dynamic team as you manage the Common Cloud Environment, driving successful projects in AWS/Azure while ensuring operational excellence and customer satisfaction in a rapidly evolving tech l...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Lead a team in developing scalable web applications and AI solutions, driving innovation in healthcare technology. Foster collaboration with stakeholders to deliver impactful software while mentoring...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $180K *

Join a dynamic team to design, implement, and enhance data center infrastructure, ensuring optimal performance and security. Collaborate across departments to execute projects effectively while mainta...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $130K *

Innovate your career by developing software applications, resolving issues, and collaborating with team members to deliver reliable systems on time. Utilize your programming expertise to enhance appli...

US-AnywhereRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$104K - $139K *

Join a dynamic team to design and enhance an AI platform, ensuring seamless deployment and operation of machine learning models at scale while prioritizing reliability and security across distributed...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Advance system designs by leading innovative engineering practices to enhance AI capabilities and scalability for education-focused platforms, collaborating cross-functionally to drive impactful solut...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$190K - $225K *

Explore your potential as you lead AI/GPU product strategies, shaping execution, customer engagement, and cross-functional collaboration to deliver cutting-edge compute solutions in dynamic markets...

US-AnywhereRemote

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K - $130K *

Develop and automate secure, scalable Azure environments that support analytics, machine learning, and AI workloads, ensuring compliance and optimal network infrastructure. Collaborate cross-functiona...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$134K - $257K *

Lead the charge in transforming nuclear engineering projects, managing fuel and safety analyses while guiding diverse teams through innovative, AI-driven solutions in a collaborative environment that...

US-AnywhereRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K *

Lead strategic legislative engagement in New England to advance clean energy policies and drive collaborative relationships across stakeholders. Ensure implementation of effective tactics to accelerat...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Help us develop innovative agentic platforms to enhance smart-home experiences, enabling systems that reason, maintain memory, and ensure safety while collaborating with cross-functional teams to deli...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $228K *

Accelerate your career by designing scalable back-end solutions that empower a digital collectibles platform. Collaborate with cross-functional teams to enhance system performance and ensure asset int...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Deliver strategic leadership and oversight for complex enterprise programs, ensuring successful execution and alignment across technology, business processes, and change management in a dynamic organi...

US-AnywhereRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $85K *

Lead the charge in ensuring optimal performance of CAD/PLM systems, supporting customer integrations, and enhancing engineering efficiency. Collaborate across teams while driving impactful solutions a...

US-AnywhereRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$184K - $356K *

Innovate by leveraging NVIDIA technology to craft high-value solutions in HPC, AI, and Machine Learning. Collaborate with diverse teams to guide strategic technical implementations and drive transform...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $180K *

Empower innovation by leading complex Microsoft solutions from proposal to execution, ensuring effective communication and technical oversight while designing transformative architecture and mentoring...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$184K - $356K *

Transform the cloud landscape by developing scalable solutions that support teams across diverse domains, enhancing productivity through automated systems and innovative infrastructure design...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $95K *

Contribute to enhancing testing processes by designing and maintaining automated scripts, integrating tests into CI/CD pipelines, and collaborating with teams to improve application quality and Vetera...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $225K *

Drive innovation and leadership as you manage engineering teams, delivering cloud-native imaging solutions while fostering collaboration and operational excellence across various functions. Empower gr...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.