Discover Senior Principal Systems Engineer Jobs

Welcome to our category for Senior Principal Systems Engineer roles. You'll find a range of opportunities spanning from systems development to technical leadership.

Senior Principal Systems Engineer Roles

As a Senior Principal Systems Engineer, you'll oversee system architecture, guide technical teams, and address the most complex engineering challenges.

Where Your Skills are Valued

Ladders values your high-level analytical, design and leadership skills. Join us, expand your career opportunities and land the job you're aiming for.

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$120K - $150K *

Champion data-driven insights by developing impactful AI systems that enhance healthcare reimbursement workflows, driving measurable business results through innovative applied engineering and collabo...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Join our team to design and build user-focused applications for controlling advanced automated aircraft systems, ensuring safety and efficiency in real-time interfaces and contributing to industry-lea...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $110K *

Transform clinical trial management by maintaining essential documents and trackers, ensuring compliance with regulations, and supporting study teams throughout trial phases. Contribute to efficient o...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Pioneer innovative solutions by leading software implementation projects that enhance healthcare analytics and data integration. Manage client relationships while ensuring projects are executed on tim...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $110K *

Join a team dedicated to enhancing military network operations while providing critical IT support on Navy ships. Collaborate with active duty personnel to ensure seamless communications and technical...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$140K - $180K *

Join a team that's transforming federal healthcare observability through advanced telemetry, operational analytics, and monitoring solutions. Leverage your expertise with Elastic Observability to enha...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $165K *

Transform the observability landscape by owning the end-to-end roadmap for telemetry, visualization, and alerting in large-scale cloud environments, driving significant impact across cross-functional...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the successful deployment and adoption of advanced drone programs within the U.S. Air Force by driving operational integration, stakeholder engagement, and ensuring mission value through effectiv...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $130K *

Oversee integration solutions within the Workday ecosystem, ensuring effective support for HR and Finance functions. Collaborate with stakeholders to design and implement scalable integrations that en...

US-AnywhereRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$205K - $225K *

Drive enterprise-grade MVP agentic AI applications through technical expertise and sales collaboration. Engage with customers to design prototypes that bridge immediate problem-solving and long-term p...

US-AnywhereRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Champion innovative web solutions by leveraging Golang and React in a collaborative remote environment. Drive technical excellence, mentor peers, and contribute to a dynamic Employee Benefits team whi...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $220K *

Join a team that's transforming healthcare with AI innovations. Tackle the challenges of metabolic health by developing advanced AI-driven solutions that enhance individual wellness through personaliz...

US-AnywhereRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $195K *

Shape the future of operational excellence by leading strategic initiatives, driving AI transformation, and enhancing corporate development. Collaborate with executives to ensure alignment, accountabi...

US-AnywhereRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$145K - $195K *

Transform strategic initiatives by leading M&A, corporate development, and AI operations. Drive cross-functional collaboration and executive reporting, ensuring programs align with business objectives...

US-AnywhereRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$220K - $255K *

Innovate financial services architecture by leading the design of secure, scalable money movement systems integral to business operations and customer experiences, while mentoring engineering teams an...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $150K *

Accelerate progress at ensuring software quality by leading test automation for cloud services. Collaborate with cross-functional teams to enhance the reliability, usability, and stability of user-fac...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $145K *

Contribute to our digital workplace by designing and administering integrated Microsoft 365 solutions. Collaborate with cross-functional teams to enhance system reliability, security, and user experie...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$220K - $240K *

Engage with CxOs to demonstrate technology solutions, leading client relationships and innovating strategies for successful IT transformations. Leverage expertise in consultative sales, technology, an...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$220K - $240K *

Join a dynamic team as you leverage technology consulting skills to advise CxOs on their transformation strategies. With a focus on client engagement, you'll solve complex problems while leading proje...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$159K - $285K *

Innovate by designing predictive models and frameworks that enhance user experiences. Collaborate across teams to integrate AI intelligence into products, guiding experimentation and influence data ar...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $120K *

Unlock your potential as you support a multitenant application ecosystem. Collaborate closely with teams to enhance Oracle EBS services, ensure operational excellence, and drive technology innovations...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$92K - $158K *

Innovate embedded firmware solutions for IoT devices supporting defense objectives. Collaborate with cross-functional teams to ensure integration and reliability in mission-critical environments. Cont...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$115K - $120K *

Grow your career by managing and analyzing project performance to ensure strategic objectives are met. Utilize best practices in program execution and Earned Value Management in this impactful role wi...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$130K - $180K *

Accelerate progress at the intersection of cloud strategy and retail transformation, driving revenue growth by engaging and empowering Microsoft partnerships within your designated client portfolio. J...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$130K - $180K *

Champion a transformative compliance experience for enterprise clients by leading engineering teams to develop scalable reporting tools and innovative data solutions that empower organizations to mana...

US-AnywhereRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What does a Senior Principal Systems Engineer do?question toggle

    A Senior Principal Systems Engineer handles system architecture, leads technical teams, and solves advanced engineering problems. They're often responsible for guiding overall system design and integration.

  • What skills do I need to have for these roles?question toggle

    Skills commonly required include system design, team leadership, analytical thinking and knowledge in systems integration.

  • What industries hire Senior Principal Systems Engineers?question toggle

    Industries like Technology, Aerospace, Defense, Telecommunications, and more require the expertise of Senior Principal Systems Engineers.