Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
Principal Scientist Algorithm Lead
$151K - $175K *
Elevate NGS diagnostic innovation by leading algorithm development to enhance clinical outcomes. Drive analytical validation, regulatory readiness, and algorithm performance in oncology, focusing on s...
Reposted 2 weeks ago
$141K *
Pioneer groundbreaking research initiatives aimed at enhancing alignment methodologies. Collaborate with a cross-functional team, driving empirical and theoretical studies while contributing to signif...
2 days ago
Senior Director/Vice President, Oligo Toxicology
$275K - $350K *
Join a team that builds integrated nonclinical safety strategies for oligonucleotide therapeutics, guiding studies from candidate selection through clinical development while ensuring scientific rigor...
4 weeks ago
Senior/Staff AI Scientist, Target Discovery
$150K - $180K *
Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...
3 weeks ago
Principal Research Scientist - Vision AI, Simulation & Physical AI
$200K - $300K *
Shape the future of embodied intelligence by leading groundbreaking research in Vision AI and multimodal foundation models. Collaborate with a dynamic team to create innovative solutions that advance...
Reposted 2 weeks ago
$90K - $100K *
Transform software delivery by managing cross-functional teams, aligning sprints, and optimizing project timelines. Drive clarity in processes and foster collaboration to ensure successful product exe...
2 days ago
Director, Technical Products and Operations
$200K - $235K *
Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...
Yesterday
$100K - $125K *
Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...
2 days ago
$165K - $290K *
Unlock potential by leading real-world evidence strategies for Cardiometabolic Health. Drive innovative data solutions, oversee impactful research initiatives, and collaborate cross-functionally to en...
2 weeks ago
$130K - $160K *
Pioneer transformative AI applications in biomedical discovery, collaborating with scientists and engineers to bridge virtual and real-world data for innovative drug discovery solutions...
6 days ago
Sr. Scientist, Analytic Science
$140K - $220K *
Lead critical analytics projects, guiding teams in statistical modeling and data quality improvement to deliver actionable insights in the credit risk domain. Collaborate effectively with cross-functi...
1 week ago
$100K - $155K *
Join a team that's dedicated to optimizing bioprocess technologies. Leverage your expertise in cell culture and bioprocessing to deliver technical support and solutions for customers, enhancing their...
Reposted 3 days ago
Sr. Principal Technical Program Manager
$176K - $221K *
Innovate by leading complex AI-centric programs, ensuring structured execution and timely delivery through precise management. Shape outcomes through strategic program oversight, integrating cutting-e...
2 days ago
$120K - $150K *
Champion strategic resourcing by analyzing data and leading staffing initiatives. Drive operational efficiency, manage complex workforce demands, and enhance financial performance while fostering grow...
Reposted yesterday
$130K - $160K *
Empower engineering excellence by solving complex technical challenges, mentoring teams, and driving innovative software solutions in a collaborative, cloud-native environment focused on data and AI i...
1 week ago
Research Scientist 6 - Ad Marketplace
$500K+*
Shape the future of our ad ecosystem by developing machine learning models and optimization algorithms that enhance ad performance while balancing revenue and user experience. Collaborate closely with...
3 weeks ago
$80K - $95K *
Join a dedicated team to oversee biospecimen lifecycle management, ensuring timely and efficient data utilization from clinical studies while acting as the primary liaison between sponsors and stakeho...
1 week ago
Senior Field Application Scientist
$120K - $140K *
Transform customer experiences through expert guidance and support in application development, training, and troubleshooting. Collaborate cross-functionally to ensure successful technology adoption an...
3 weeks ago
$168K - $210K *
Engage in shaping AI-enabled software architecture, translating business needs into secure, scalable solutions while mentoring teams and collaborating across functions on modern engineering and respon...
2 weeks ago
$141K - $196K *
Champion the future of transformative decision systems by guiding teams on optimizing offer strategies, conversion modeling, and systems design to enhance borrower experiences and improve marketplace...
Reposted 3 weeks ago
$110K - $130K *
Transform AI research into actionable insights. Collaborate with teams to prioritize projects, set milestones, and evaluate ROI, driving accountable progress while fostering a culture of scientific ex...
2 weeks ago
$105K - $135K *
Shape the future of media analytics as you drive innovative reporting and optimization strategies for omnichannel clients, translating data into actionable insights that enhance campaign performance a...
3 weeks ago
Director of Product, Applied Research Intelligence
$145K - $212K *
Drive the development of AI-driven solutions for life-sciences research, collaborating across teams to transition innovative features from concept to launch, while ensuring alignment with researchers...
Reposted 5 days ago
$130K - $155K *
Engineer innovative solutions as a Senior Product Manager, driving the product lifecycle from conception to launch. Collaborate cross-functionally to enhance and expand market-leading products, ensuri...
Yesterday
Staff Engineer - Ex Atmospheres
$100K - $120K *
Take ownership of quality assessments and certification reviews within the explosive atmosphere division. Conduct audits, ensure compliance with international standards, and collaborate with teams to...
Yesterday
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.