Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Principal Software Engineer, Agentic Data Platform
$255K - $290K *
Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...
1 week ago
Sr. Principal Pilot - USMC Aviation
$129K - $193K *
Join a dynamic team as a Subject Matter Expert, guiding mission planning solutions for USMC aviation. Collaborate with engineers and pilots to enhance operational capabilities and deliver impactful tr...
2 days ago
Director of Infrastructure Engineering
$225K - $325K *
Drive transformative initiatives in cloud infrastructure engineering, ensuring high availability and performance across global networking, HPC systems, and distributed storage, while mentoring teams t...
Reposted 4 weeks ago
$116K - $178K *
Join us in supporting our rapid growth by providing legal expertise in contract negotiations and management. Collaborate with teams across the Americas to ensure compliance and drive revenue while mai...
3 weeks ago
Lead, Operations Strategy - Specialty Services Implementation
$90K - $100K *
Join a dynamic team to drive the implementation of innovative service lines, enhancing clinician and patient experiences. Collaborate cross-functionally to optimize operations and lead initiatives tha...
1 week ago
$158K - $281K *
Elevate your career by leading high-impact delivery teams to drive strategic technology solutions. Collaborate with stakeholders to shape roadmaps, optimize processes, and ensure alignment with busine...
Yesterday
Senior Systems Designer, Monetization
$110K - $130K *
Join a dynamic team to shape player engagement through innovative monetization systems. You'll design in-game stores and offers, collaborating with cross-functional teams to enhance the player experie...
5 days ago
$129K - $173K *
Join a team that's redefining API integration by leveraging your expertise to guide customers in automating service processes. Collaborate with technical sellers and enhance API adoption through effec...
2 days ago
Senior Technical Lead, Enterprise Application Integrations
$119K - $150K *
Shape the future of enterprise application integrations by leading technical design and implementation for Finance, Accounting, and Supply Chain projects, collaborating with cross-functional teams to...
Yesterday
$110K - $130K *
Innovate commissioning processes in Life Science and Advanced Manufacturing. Lead a team, manage project workloads, and ensure successful startup and commissioning across multidisciplinary projects wh...
3 weeks ago
$125K - $150K *
Champion our commissioning efforts by leading a dynamic team, managing project workflows, and driving innovative solutions in Life Science and Advanced Manufacturing. Collaborate across disciplines to...
3 weeks ago
Product Director, Institutional Solutions
$126K - $168K *
Lead the charge in shaping and executing product strategy for B2B learning solutions, driving innovation and market impact while collaborating with cross-functional teams to deliver high-quality produ...
1 week ago
Sales Consultant, Trauma (Raleigh - Durham, NC) - Johnson & Johnson MedTech - Orthopaedics
$80K - $95K *
Champion innovative solutions in MedTech sales by building relationships with surgeons and healthcare systems. Drive sales growth through strategic planning and exceptional customer service in a dynam...
4 days ago
Sales Consultant, Trauma (Raleigh - Durham, NC) - Johnson & Johnson MedTech - Orthopaedics
$85K - $100K *
Drive sales and foster relationships with surgeons in the Raleigh-Durham area. Utilize your expertise to implement strategies that meet customer needs and enhance patient care through innovative ortho...
4 days ago
Senior Project Manager - U.S. Healthcare Programs
$110K - $130K *
Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...
Reposted 3 weeks ago
$150K - $180K *
Champion data-driven insights and solutions, collaborating with cross-functional teams to shape analytics practice and drive impactful decision-making across various business domains...
Reposted 4 weeks ago
$150K - $180K *
Shape the future of our platform by leading cross-organizational initiatives, defining architectural standards, and mentoring engineers. Drive technical excellence and influence across teams while own...
2 weeks ago
Client Success Manager (Midwest)
$80K - $110K *
Drive client success by managing small to medium accounts, enhancing engagement, and leveraging data insights to improve health outcomes and revenue growth. Collaborate with teams to implement solutio...
2 days ago
$110K - $130K *
Unlock potential by driving strategic growth within enterprise accounts. Lead cross-functional teams to manage client relationships, develop account strategies, and identify new opportunities, ensurin...
Reposted 3 weeks ago
$71K - $97K *
Elevate your career by driving provider education and documentation improvements. Collaborate with teams to enhance quality care through tailored strategies and impactful presentations, ensuring compl...
Yesterday
Family Nurse Practitioner / Physician Assistant
$90K - $110K *
Champion high-quality healthcare delivery in a dynamic environment, ensuring patient satisfaction through both in-clinic and telehealth services. Collaborate with a team to implement protocols and pro...
3 weeks ago
$125K - $150K *
Champion strategic sales enablement initiatives while partnering with client and distribution leaders. Utilize investment expertise to deliver scalable training programs and enhance content accessibil...
3 weeks ago
Senior Clinical Trial Manager - Metabolic - U.S.
$112K - $222K *
Lead clinical site management teams through project lifecycle, ensuring effective monitoring and communication. Drive project deliverables, budget management, and sponsor engagement to achieve impactf...
Reposted 3 days ago
$135K - $192K *
Champion investment risk management by analyzing portfolios, enhancing reporting systems, and leveraging AI tools. Collaborate across teams to ensure compliance and optimize capital adequacy while dri...
2 weeks ago
Pre-sales Solutions Consultant, Clinical
$90K - $110K *
Engage with clients to showcase innovative healthcare solutions, driving sales success through impactful demonstrations and expert guidance. Collaborate with sales teams to address client needs and en...
2 weeks ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.