Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$115K - $130K *

Grow and strengthen strategic relationships with healthcare systems to drive business success. Optimize networking and sales strategies to secure new contracts and expand our reach within the healthca...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Staffing

$125K - $150K *

Pioneer comprehensive ServiceNow solutions, leading implementations and mentoring teams. Drive architectural design, process automation, and integrations while ensuring optimal performance and governa...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$208K - $220K *

Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $190K *

Join a team that's dedicated to driving revenue growth in the Pulmonary sector by engaging healthcare professionals and implementing strategic initiatives to enhance product utilization and foster str...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$191K - $293K *

Drive the design and development of scalable backend services, ensuring reliable data delivery from Tanium to external systems. Mentor engineers and shape technical direction while enhancing observabi...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by leading a technical team to enhance collaboration tools in a dynamic, cloud-based environment. Engage with federal clients, drive Agile practices, and ensure toolset efficiency...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in designing and delivering AI applications on Snowflake, optimizing data governance and architecture. Collaborate with clients and engineers to transform concepts into scalable, secur...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Champion your career by conducting in-depth research and analysis to produce impactful industry insights for top executives in home services, driving strategic decisions and fostering key relationship...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $149K *

Drive strategic payer partnerships and enhance revenue cycle performance through oversight, mentorship, and data analysis. Collaborate across teams to resolve complex issues and improve operational ef...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$242K - $282K *

Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $143K *

Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $114K *

Grow your career with a dynamic role focused on driving sales and clinical engagement in Electrophysiology Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Advance operational excellence in pain management by leading multi-site practices, enhancing patient access, and driving financial performance through strategic partnerships and best practices impleme...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $275K *

Elevate your career by driving innovative solutions that align technology with business strategy. Own end-to-end solution architecture while mentoring teams and collaborating with stakeholders for imp...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $145K *

Strategize initiatives to enhance workforce alignment and Agile practices, driving high performance in IT services for federal clients while fostering a collaborative culture and supporting strategic...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$228K - $285K *

Join us to build internal actuarial capabilities, measuring and pricing economic value across programs. Collaborate with Finance, Clinical, and Commercial teams to develop robust ROI models and perfor...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K *

Transform US commercial operations, leading growth through innovative revenue strategies, while enhancing patient experience and building high-performing teams across regional and clinical leadership...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $156K *

Transform the contracting landscape by managing complex agreements, balancing legal and business needs, and collaborating with cross-functional teams to drive successful sponsor negotiations and contr...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $205K *

Lead the charge in shaping clinical strategy across a vast network of dialysis clinics, driving quality outcomes and patient safety while mentoring clinical leaders and fostering collaboration with ke...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join us to lead a dynamic team, driving performance and business growth while fostering collaboration and customer loyalty. Your leadership will shape operational success and enhance talent developmen...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$180K - $215K *

Drive regional success by leading launch execution and building high-performing teams. Foster customer relationships and ensure alignment with corporate goals in a fast-paced, entrepreneurial environm...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$260K - $310K *

Transform the engineering landscape by leading dual teams in the Clinical Division, driving technical excellence and career growth, while effectively managing product delivery and leveraging AI capabi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $222K *

Lead the creative vision and design for engaging hero characters, overseeing combat, traversal, and gameplay systems. Collaborate across teams to ensure high-quality execution and innovation in third...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$104K - $114K *

Elevate your career by providing exceptional aesthetic treatments while ensuring top-notch patient care and documentation. Collaborate in a dynamic team environment with a focus on continuous improvem...

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.