Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$160K - $190K *

Drive operational excellence in patient support programs, enhancing access and outcomes through strategic leadership, compliance, and team development. Oversee key functions to ensure a patient-center...

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $130K *

Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$140K *

Join a team that's dedicated to delivering innovative mental health care through comprehensive evaluations and tailored treatment plans, utilizing advanced techniques in a collaborative, fast-paced en...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Lead the delivery of high-quality ABA therapy in a hybrid role, balancing remote and in-person client engagement. Collaborate with clinical teams to develop individualized behavior plans and support f...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join a team that shapes the future of pediatric rehabilitation through innovative care delivery. Collaborate with healthcare professionals to provide comprehensive treatment plans, enhance patient out...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $132K *

Engage as a key technical leader in enterprise AI/ML architecture, collaborating with clients to design scalable solutions. Drive AI development and deployment, ensuring alignment with business needs...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Lead end-to-end client implementations, ensuring timely and impactful project delivery while collaborating across teams to drive exceptional customer experiences and measurable outcomes in a dynamic h...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion public safety operations across North America, leading program directors to ensure effective training, deployment, and customer satisfaction while aligning resources and operational prioritie...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$79K - $118K *

Engage in delivering high-quality surgical care as a Registered Nurse in a dynamic Operating Room team, collaborating with surgeons and anesthesiologists to ensure safe, compassionate, and patient-cen...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Champion exceptional patient care and operational excellence as you lead nursing services in our ambulatory clinics. Drive quality improvement and optimize workflows, ensuring compliance with regulato...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$199K - $270K *

Tackle the complexities of backend engineering by developing robust API integrations, building ETL pipelines, and collaborating with cross-functional teams to enhance system reliability and performanc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $160K *

Take ownership of B2B integrations as a key technical leader, collaborating across teams to deliver effective solutions that drive customer success and evolve with innovative IoT technology. Expect a...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$193K - $322K *

Join a team that leads the charge in advancing clinical AI and technology, shaping solutions that enhance clinician experience and patient outcomes while navigating complex healthcare environments...

United StatesRemote

1 month ago

  •   11 - 15 years exp.  •   Healthcare

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $140K *

Unlock potential by joining a mission-driven team focused on preventative care. Collaborate with healthcare professionals to enhance patient health and quality of life through comprehensive assessment...

North Carolina, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $220K *

Transform LLM inference efficiency by leading the performance measurement, diagnosis, and enhancement efforts to optimize customer experience through cost-effective and speedy solutions in a hands-on...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$245K - $265K *

Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's at the forefront of cybersecurity, leading advanced incident response efforts. As a senior operational lead, you'll coordinate critical responses, ensuring effective communication a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$174K - $374K *

Lead the charge in clinical oversight and mentorship, driving innovative medical solutions across diverse programs. Collaborate with cross-functional teams to ensure evidence-based decision-making and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$89K - $170K *

Pioneer innovative software solutions by developing and maintaining high-quality applications. Collaborate within a cross-functional team to enhance system performance and reliability, ensuring except...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Innovate with us to enhance patient safety in global clinical studies. As a key medical expert, you'll provide critical input, oversee trial safety, and collaborate with teams to ensure compliance and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.