Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$180K - $220K *

Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $185K *

Transform complex workflows by leading AI-driven change initiatives, guiding senior leaders through redesign and adoption processes, and ensuring measurable outcomes in legal, tax, and trade sectors...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$150K - $200K *

Champion transformative solutions by leading Salesforce implementations and optimizing client engagements. Leverage your expertise to deliver impactful results while driving project success, enhancing...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$124K - $186K *

Join a dynamic team to advance cancer research through innovative experiments focused on receptor tyrosine kinases. Develop and document key findings to drive insights in oncology, contributing to pub...

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Transform healthcare delivery by providing emergency and primary care at remote worksites. Collaborate with clinical teams to ensure quality assurance and support field staff while maintaining essenti...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by leading contract negotiations for clinical research, ensuring compliance and efficiency in agreements with industry sponsors. Collaborate with diverse teams to enhance processes an...

Chapel Hill, NCRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $300K *

Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Optimize respiratory care delivery by leading clinical and educational initiatives while supporting staff and patient needs across all age groups in a dynamic hospital setting...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Shape the future of architectural design by leading complex data center projects, ensuring high-quality documentation, collaborating with diverse teams, and driving successful project outcomes through...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$130K - $160K *

Transform financial strategies by leveraging your expertise in analyses, forecasting, and IT governance. Drive impactful recommendations and enhance operational efficiency through innovative financial...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a team that's redefining plumbing engineering by designing innovative systems across diverse sectors, including healthcare and commercial projects, while ensuring code compliance and collaboratio...

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$112K - $222K *

Advance clinical site management with leadership to optimize study operations and deliverables. Establish strong sponsor relationships while overseeing project activities and motivating remote teams t...

Durham, NCRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion comprehensive health and welfare benefits management, overseeing strategy, compliance, and administration for a multi-state workforce. Drive vendor partnerships and enhance employee experienc...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $291K *

Join a team that's dedicated to empowering healthcare professionals through innovative medical devices. Lead a high-performing sales organization, drive revenue growth, and enhance patient care with c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Transform client outcomes by delivering play-based ABA therapy and leading a dedicated team. Collaborate with peers to create individualized treatment plans and empower families through evidence-based...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Shape the future of ABA therapy by conducting assessments, developing treatment plans, and mentoring a dedicated team to ensure exceptional outcomes for children and families in a supportive clinic en...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $177K *

Elevate decision-making through advanced behavioral insights and causal inference. Lead a team to design measurement strategies, enhance operational investments, and drive impactful outcomes across en...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $165K *

Shape the future of billing and collections by driving product strategy and enhancing user experiences. Collaborate with cross-functional teams to deliver reliable payment solutions that boost revenue...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Deliver leadership and governance for global clinical study management, ensuring projects meet timelines and budgets while fostering collaboration and operational excellence across teams and stakehold...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $165K *

Drive product lifecycle strategy and portfolio performance in women's health. Leverage deep expertise and AI tools to enhance decision-making, manage partnerships, and ensure successful product launch...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $165K *

Join a team that's redefining women's health by leading product strategy and lifecycle management. Drive innovation and profitability through deep domain expertise, strategic partnerships, and AI-enha...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team to enhance decision-making and support EHRM initiatives. Drive program management, facilitate stakeholder engagement, and contribute to strategic communications while ensuring effe...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$71K - $100K *

Join a team that's dedicated to delivering exceptional orthopedic care in a fast-paced environment. Collaborate with an interdisciplinary team to enhance patient recovery and outcomes while fostering...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$217K - $281K *

Champion cybersecurity excellence by leading CrowdStrike Falcon deployments, optimizing client engagements, and mentoring teams to enhance security operations and client relationships in a dynamic env...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.