Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Elevate your career by driving innovative solutions in life sciences. Collaborate with clients to enhance product planning, analytics, and compliance, while leading data management and predictive mode...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Business Services

$120K - $165K *

Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$134K - $162K *

Contribute to the advancement of medical physics by leading dosimetry analysis for radiopharmaceuticals. Collaborate with cross-functional teams to drive research in drug development and improve imagi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K *

Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Transform patient care by collaborating with a multidisciplinary team to develop and implement effective rehabilitation plans, ensuring optimal functional outcomes and independence for diverse patient...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$135K - $210K *

Advance product development by managing end-to-end processes, collaborating with cross-functional teams, and driving timelines. This role requires a proactive approach to navigate ambiguity and ensure...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$122K - $342K *

Lead innovative therapeutic strategy development for early clinical trials, integrating scientific, operational, and business insights. Drive client engagement and ensure project success from proposal...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $273K *

Lead cross-functional collaboration and technical delivery for a multi-year AI initiative, ensuring alignment with product and engineering teams while managing risks and dependencies to drive successf...

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$122K - $187K *

Lead strategic initiatives to drive sales growth and enhance customer relationships within assigned accounts, leveraging your expertise in enterprise software to exceed quotas and deliver tailored sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$123K - $168K *

Drive growth and product acceptance in a defined territory by building relationships with healthcare providers. Educate stakeholders on product benefits while managing promotional resources and execut...

North Carolina, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Accelerate progress at the forefront of Revenue Recovery by leading teams to optimize clinical coding and compliance. Drive operational excellence, enhance client satisfaction, and achieve financial t...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $216K *

Lead the technical implementation of a large-scale platform modernization program, ensuring adherence to architectural standards and providing hands-on guidance across multiple teams and vendors for s...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$101K - $126K *

Empower a team of behavior technicians while overseeing neurodiversity-affirming clinical programming. Enjoy flexible scheduling and administrative support, focusing on impactful care for children wit...

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$168K - $188K *

Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform healthcare administration by leading enterprise-wide HIMS operations, ensuring compliance and driving performance improvement across a multi-state network while fostering an engaged workforc...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$88K - $105K *

Elevate project outcomes by leading coordination and documentation efforts. Drive quality within teams, foresee risks, and ensure timely deliverables to achieve design intent. Foster mentorship and co...

1 month ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$210K - $250K *

Drive strategic medical initiatives in cardiology, providing expert guidance and leadership across project teams while ensuring compliance with regulatory standards and fostering high-performing teams...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $110K *

Elevate your career as you lead a dedicated nursing team, ensuring exceptional patient care and compliance with standards. Drive excellence and foster a positive environment while supporting the Direc...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $220K *

Transform patient care by delivering high-quality behavioral healthcare. Join a dynamic team of Psychiatric Nurse Practitioners dedicated to clinical excellence and work-life balance while serving pat...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$232K - $290K *

Lead the charge in optimizing workforce operations and analytics for multi-condition health care services. Develop strategies for capacity planning, staffing, and analytics to drive efficiency and sup...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$142K - $185K *

Pioneer strategic HR initiatives to enhance corporate functions and build leadership capabilities. Collaborate across departments to anticipate talent needs, shape organizational design, and drive wor...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$109K - $164K *

Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Champion innovative solutions as a Senior Implementation Project Manager, leading complex software implementations and driving customer success through effective project management and collaboration a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.