Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$115K - $322K *

Join a team that's impacting patient safety through medical advisory support to clinical trials. Collaborate on protocol issues, facilitate training, and ensure compliance as a key player in driving p...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in identifying and assessing cyber threats to bolster law enforcement and counterintelligence efforts. Collaborate with teams to develop threat signatures and implement incident respon...

Raleigh, NCRemote

1 month ago

  •   Less than 5 years exp.  •   Staffing

$88K - $105K *

Join a dynamic team to analyze cyber threats and bolster national security. Leverage your expertise to identify criminal activities, support investigations, and enhance incident response measures in a...

1 month ago

  •   Less than 5 years exp.  •   Staffing

$125K - $150K *

Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $210K *

Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$85K - $110K *

Advance operational excellence by leading investigations into quality and safety events. Collaborate with cross-functional teams to identify root causes and implement corrective actions, enhancing rel...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$69K - $111K *

Transform operational excellence by leading investigations into quality and safety events. Utilize root cause analysis and HOP principles to enhance reliability and drive continuous improvement across...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform healthcare delivery by leading operations for a growing telehealth practice. Collaborate with clinical teams to enhance patient care through innovative solutions and efficient workflows, ens...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive impactful IT project delivery in a multi-site healthcare environment. Lead complex transformations, enhance governance, and foster stakeholder collaboration while ensuring tangible business outc...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $224K *

Drive growth in the Neurodegenerative Disease sector by developing strategic partnerships with health systems and academic centers, leveraging existing relationships to create innovative solutions tha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$208K - $416K *

Explore a rewarding opportunity to deliver top-notch telemedicine care with flexible scheduling. Work alongside a supportive team to provide continuous primary care and leverage technology for seamles...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Transform the provider referral landscape by leading strategic growth initiatives, building key relationships, and enhancing outreach efforts to ensure a robust pipeline of patient referrals in a dyna...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Transform the communications landscape by building a dynamic team that drives brand relevance through strategic earned media, influencer relations, and corporate communications, ensuring a consumer-fi...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $100K *

Join a team that's passionate about transforming complex scientific data into engaging communications. Collaborate with cross-functional experts to deliver high-quality medical content and strategies...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Shape the future of client relations as a Program Manager, overseeing program execution, financial oversight, and stakeholder collaboration to drive operational excellence and innovative solutions whi...

North Carolina, USRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform business needs into technical solutions by collaborating with stakeholders, driving design, and ensuring successful delivery across diverse initiatives. Engage in the full lifecycle from dis...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $195K *

Lead the charge in shaping technical direction and mentoring teams while driving program delivery and fostering a culture of growth and collaboration in a dynamic engineering environment...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $210K *

Champion innovative AI and digital strategies through complex client engagements. Lead cross-functional teams, influencing executive stakeholders, and deliver impactful solutions that scale with effic...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $210K *

Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Empower operational technology integration by connecting plant systems to MaintainX. Collaborate with sales and implementation teams to ensure seamless data flow and enhance customer experiences throu...

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $95K *

Champion operational excellence by leading clinic operations, enhancing team performance, and driving key metrics. Collaborate cross-functionally to deliver exceptional patient care while navigating c...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Elevate your career by driving innovative solutions in life sciences. Collaborate with clients to enhance product planning, analytics, and compliance, while leading data management and predictive mode...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Business Services

$120K - $165K *

Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.