Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$90K - $110K *

Manage primary medical care within an occupational health program, ensuring quality patient management, diagnostic testing, and therapeutic procedures while collaborating with healthcare professionals...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Design engaging multimedia content that embodies brand consistency across various formats, from print to digital. Collaborate with teams to create compelling visuals, animations, and videos that reson...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$130K - $150K *

Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$97K - $193K *

Drive excellence in clinical research as a Senior CRA, ensuring quality and compliance throughout the study lifecycle. Collaborate with sites and teams to enhance patient safety and data integrity, in...

Durham, NCRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $117K *

Lead the pediatric clinical program, ensuring safe transitions for medically complex children. Collaborate with families and healthcare teams to coordinate care, educate caregivers, and maintain clini...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Engage in delivering comprehensive medical care as a Physician Assistant or Nurse Practitioner, collaborating with a multidisciplinary team to enhance patient outcomes in both inpatient and outpatient...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K *

Transform mental health care by building strategic partnerships with providers to enhance access to specialized OCD treatment. Drive growth through relationship-building, education, and effective refe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $165K *

Transform your career by leading revenue cycle consulting projects, managing junior staff, and driving operational improvements while building strong client relationships. Leverage your expertise in h...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Innovate post-acute payment integrity by developing and optimizing audit concepts for DME, home health, and infusion therapy claims. Collaborate cross-functionally to ensure compliance and enhance ope...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$79K - $118K *

Bring your expertise to a collaborative team dedicated to delivering outstanding patient care. Drive quality outcomes while providing treatment assessments and developing effective patient plans in a...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $322K *

Join a dynamic team to lead and empower Solutions Engineers, driving technical sales excellence while fostering collaborative innovation and ensuring customer success through strategic insights and re...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Innovate by developing scalable applications and data pipelines, leveraging Python and cloud platforms. Collaborate with cross-functional teams to modernize enterprise systems and enhance backend serv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$168K - $231K *

Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $165K *

Advance patient care by leading a pharmacist-led program focused on specialty therapeutics. Collaborate with healthcare teams to optimize medication management, enhance patient outcomes, and provide e...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $175K *

Grow expertise in Operational Technology security, leading critical engagements across industrial systems. Collaborate on advanced methodologies while mentoring others and contributing to pivotal rese...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$400K - $500K+*

Drive advanced neuroradiology practices in a 100% remote role, collaborating with top specialists while maintaining work-life balance. Enjoy a supportive physician-led environment focused on clinical...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Join a dynamic team to provide comprehensive patient care in a busy outpatient setting. Engage in primary, urgent, and pain management services while building strong patient relationships and ensuring...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Elevate your career by joining a dynamic team providing comprehensive patient care, including primary, urgent, and pain management services. Collaborate with esteemed providers in a modern outpatient...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Oversee the resolution of complex technical issues, mentor analysts, and drive continuous improvement initiatives to enhance service reliability and user experience within the service desk environment...

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $147K *

Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $190K *

Shape the future of our technology landscape by architecting scalable, secure systems that empower a high-growth environment through innovative SaaS and AI strategies. Lead the implementation of best...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.