Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$95K - $115K *

Transform drug discovery by leveraging your expertise in molecular biology and biochemistry. Collaborate with cross-functional teams to validate novel targets and drive innovative research in neurolog...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$81K - $112K *

Champion compliance and innovation in sterility assurance, collaborating cross-functionally to support regulatory mandates and ensure product safety and efficacy through sterilization processes in man...

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $206K *

Transform the accounting landscape by leading strategic initiatives that enhance operational efficiency, standardize processes, and drive technology integration, all while ensuring public company read...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$200K - $275K *

Transform financial planning and analysis for diverse divisions, optimize performance insights, and shape executive decisions. Drive accountability through robust forecasting, modeling, and communicat...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$90K - $140K *

Lead the design and coordination of plumbing and fire protection systems across complex projects. Provide technical expertise, mentor the design team, and collaborate with stakeholders to ensure compl...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$79K - $114K *

Engineer robust full stack enterprise applications in a dynamic AWS environment. Collaborate with cross-functional teams to design, develop, and maintain high-quality solutions while troubleshooting c...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$76K - $110K *

Lead operational excellence in Medical and Clinical Affairs, managing grants, coordinating cross-functional teams, and ensuring efficient program execution to enhance healthcare outcomes and support s...

Woburn, MARemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $110K *

Champion operational excellence in Medical and Clinical Affairs, overseeing grant management, project coordination, and cross-functional collaboration to drive strategic initiatives and ensure high-qu...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$81K - $116K *

Transform patient care by executing advanced C.A.T. scan procedures, ensuring comfort and safety while collaborating with radiologists to deliver high-quality diagnostic imaging for diverse patient ne...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$165K - $205K *

Lead the charge in cybersecurity governance and risk management consulting. Drive client engagements, develop security frameworks, and mentor teams while ensuring alignment with industry standards and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$130K - $160K *

Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$104K *

Unlock potential by delivering expert travel health consultations and vaccinations. Enjoy autonomy in a dynamic role, supported by clinical leadership, while developing specialized knowledge in travel...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower health systems with your PharmD expertise, driving effective implementations and customer success in our AI-driven pharmacy platform. Shape workflows, maximize ROI, and enhance adoption throug...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $500K+*

Lead client-focused financial strategies by developing, executing, and managing personalized investment and planning solutions while ensuring compliance and delivering exceptional service tailored to...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$92K - $110K *

Champion the operational excellence of a Radiation Oncology department by managing clinical, administrative, and compliance functions. Lead a dedicated team to enhance patient safety, service quality...

3 days ago

  •   5 - 7 years exp.  •   Staffing

$215K - $230K *

Drive compliance and operational excellence in government pricing and contract administration. Lead cross-functional collaboration, oversee vendor management, and ensure adherence to regulations while...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $190K *

Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $140K *

Join a team that's dedicated to transforming healthcare through innovative philanthropy. As a key player, you'll manage donor relationships, drive fundraising efforts, and collaborate with diverse sta...

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Lead the charge in MedTech sales by driving innovative strategies and managing teams to enhance orthopedic solutions. Foster new relationships, ensure client satisfaction, and achieve sales goals thro...

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$168K - $283K *

Empower your career by leading early-stage clinical trials in neurodegeneration and neuropsychiatry. Collaborate cross-functionally to drive scientific strategy, data interpretation, and regulatory su...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$168K - $283K *

Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Join a team that's driving innovation in late-stage clinical trials for Orexin-targeted therapies. Leverage your expertise to ensure compliance, enhance study execution, and collaborate across functio...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $180K *

Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.