Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$134K - $162K *

Contribute to the advancement of medical physics by leading dosimetry analysis for radiopharmaceuticals. Collaborate with cross-functional teams to drive research in drug development and improve imagi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$101K - $155K *

Engage in dynamic strategy projects by conducting rigorous research and analysis. Collaborate with a dedicated team to support leadership decisions, ensuring high-quality deliverables while fostering...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$297K - $370K *

Champion the execution of global clinical programs, leading cross-functional teams in advancing innovative neuropsychiatric therapies. Leverage your expertise to drive strategy, oversee trial design...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $190K *

Champion exceptional patient care by leading a dynamic team of advanced practice providers in a new 24/7 Midwifery and Gynecology program. Shape clinical operations, foster professional growth, and ma...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$122K *

Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$91K - $120K *

Champion patient care by providing direct support and assessments as a key member of a multidisciplinary team, ensuring a safe therapeutic environment and contributing to treatment plans that enhance...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$117K - $201K *

Accelerate your career in Regulatory Affairs by driving FDA strategies for innovative cardiovascular medical devices. Collaborate with global teams to influence product approvals and enhance regulator...

Danvers, MARemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Transform the future of cardiovascular care as you oversee regulatory strategies and submissions for innovative digital health medical devices. Collaborate with global teams to ensure compliance and f...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$214K - $241K *

Champion clinical study success by providing scientific expertise and cross-functional collaboration, ensuring efficient execution of Clinical Development Plans from Phase I to III trials...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $187K *

Lead strategic initiatives to drive sales growth and enhance customer relationships within assigned accounts, leveraging your expertise in enterprise software to exceed quotas and deliver tailored sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Drive strategic partnerships to enhance educational and workforce initiatives, fostering collaboration with industry and community partners. Focus on enrollment growth and engagement through innovativ...

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$62K - $135K *

Transform group fitness experiences by coaching dynamic workouts, motivating clients, and ensuring safety. Leverage your expertise to foster a supportive environment and help individuals achieve their...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$135K - $160K *

Shape the future of AI in healthcare by leading enterprise-wide adoption, governance, and risk management. Drive innovation and compliance while ensuring AI initiatives deliver measurable business val...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Accelerate progress at the forefront of Revenue Recovery by leading teams to optimize clinical coding and compliance. Drive operational excellence, enhance client satisfaction, and achieve financial t...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $216K *

Lead the technical implementation of a large-scale platform modernization program, ensuring adherence to architectural standards and providing hands-on guidance across multiple teams and vendors for s...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$130K - $217K *

Deliver innovative full-stack solutions that drive business success while collaborating with cross-functional teams. Maintain high code quality and scalability to enhance user experiences in a fast-pa...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$168K - $188K *

Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate healthcare project outcomes by leading multi-disciplinary teams, managing complex schedules, and ensuring adherence to quality standards. Utilize your expertise to drive large-scale projects f...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $190K *

Lead the charge in engineering foundations for enterprise AI, collaborating across teams to enhance delivery, reliability, and secure production use of AI technologies, driving innovation and improvin...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$196K - $342K *

Empower oncology research by leading a cross-functional team to address key mechanistic questions, driving insights from clinical observations to inform pipeline growth and enhance therapeutic strateg...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$185K - $232K *

Inspire digital marketing excellence by leading strategy and execution across diverse healthcare initiatives, enhancing engagement through innovative channels while ensuring compliance and collaborati...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform healthcare administration by leading enterprise-wide HIMS operations, ensuring compliance and driving performance improvement across a multi-state network while fostering an engaged workforc...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Empower scientific advancement by leading in vivo pharmacology studies, designing innovative experiments, and delivering impactful immunology data across multidisciplinary research teams in inflammati...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Join a team that's dedicated to providing essential mental health services in various nursing facilities. Enjoy clinical autonomy, flexible schedules, and excellent compensation while making a meaning...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $100K *

Elevate your career as a therapist with flexible scheduling options, including hybrid and telehealth opportunities. Join a supportive team that values your expertise and offers competitive compensatio...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.