Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$299K *

Drive comprehensive patient care by joining a collaborative network of outpatient clinics, supported by hospitals and specialists, ensuring a seamless healthcare experience in a community-focused envi...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$270K - $310K *

Drive strategic leadership in patient safety sciences, overseeing activities, fostering collaboration, and building a high-performing team to enhance safety measures across oncology clinical trials an...

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$117K - $191K *

Join a team that's dedicated to providing exceptional surgical care, assisting in operating rooms, performing bedside procedures, and managing post-operative patient care in a dynamic healthcare envir...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$225K - $240K *

Architect innovative clinical strategies and collaborate with cross-functional teams to drive the execution and analysis of clinical studies, ensuring high-quality data delivery and alignment with dev...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$164K - $205K *

Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Champion global regulatory strategies by providing expert support from development to approval. Lead cross-functional teams and ensure compliance with US and international regulations while fostering...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $180K *

Lead operational excellence for back-office services while leveraging expertise in financial technology and client management to enhance onboarding and support for asset management projects in a colla...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$191K - $293K *

Lead the charge in providing strategic employment law counsel, guiding the People team and stakeholders on compliance, investigations, and policy development to foster a supportive workplace while mit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$167K - $191K *

Lead the development and execution of HEOR/RWE strategies for neurology assets, ensuring robust evidence generation from early development through launch. Collaborate with cross-functional teams to su...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $185K *

Empower clients by leveraging deep ONESOURCE Direct Tax expertise to design innovative solutions using AI and automation tools. Engage directly with customers, manage projects, and drive efficiency wh...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Media

$100K - $120K *

Elevate your career by leading financial planning and analysis, managing budgets, and driving strategic insights. Collaborate with cross-functional teams to enhance operational performance and deliver...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$183K - $252K *

Join a team that's redefining medical strategy in Rare Disease. As a key player, you'll collaborate across functions to enhance patient outcomes in SMA and ALS, driving initiatives that align with glo...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$60K - $108K *

Join a team that's dedicated to providing exceptional pediatric care through effective triage and patient support. Utilize your nursing expertise to assess needs, coordinate care, and enhance patient...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $180K *

Join a team that's leading complex, cross-functional projects to drive claims modernization. Oversee governance, reporting, and stakeholder engagement while ensuring alignment with organizational obje...

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$125K - $140K *

Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Transportation

$110K - $125K *

Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$238K - $323K *

Partner with us to shape the medical strategy for early-stage CNS clinical programs, driving scientific engagement and collaboration across teams to enhance patient access and commercial growth in neu...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $95K *

Drive the successful adoption of advanced hearing solutions by providing expert clinical support and education to healthcare professionals. Collaborate closely with cross-functional teams to enhance p...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in advancing genetic testing for high-risk patients. Collaborate with healthcare teams to assess risks, provide support, and ensure continuity of care while contributing to community h...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $152K *

Execute regulatory strategies for global product approvals, guiding teams through the lifecycle and managing submissions. Foster agency relationships, maintain compliance, and lead audits while mentor...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $120K *

Help us unlock potential by providing proactive IT support to end-users, troubleshooting hardware, software, and network issues to drive productivity. Collaborate in a hybrid role that fosters teamwor...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate your career by developing and maintaining the Master Production Schedule, ensuring alignment of production capacity and material availability while enhancing planning processes for optimal exe...

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$125K - $150K *

Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.