Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$112K - $179K *

Unlock innovative cloud solutions by designing and governing enterprise architectures on AWS and Azure. Collaborate with cross-functional teams to ensure compliance, optimize performance, and lead clo...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$170K - $240K *

Unlock potential by serving as a strategic technical advisor for key enterprise customers, guiding architecture decisions and aligning technical plans with business outcomes to ensure successful imple...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Lead the charge in enhancing organizational security by developing security frameworks, assessing controls, and collaborating with technical teams to create a resilient security architecture for moder...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$282K - $353K *

Transform the AI landscape by owning technical wins in enterprise deals, leveraging data architecture, and delivering superior AI solutions. Collaborate with executive teams to validate and design inn...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Drive network security innovation by developing and integrating robust software solutions. Collaborate with cross-functional teams to enhance security infrastructure and ensure seamless functionality...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive customer success as a technical expert, partnering to optimize IoT deployments. Your strategic insights will enhance service adoption and expand account growth, delivering tangible business outc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $165K *

Join our team to provide advanced support as a Senior Network Engineer, overseeing complex issues across multiple technologies and enhancing network performance for diverse client environments. Drive...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $118K *

Drive the evolution of scalable, secure platforms by architecting solutions that enhance network intelligence and application delivery, collaborating with cross-functional teams to optimize performanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Contribute to the design and governance of enterprise integration solutions, ensuring seamless connectivity across applications and data services. Lead strategic initiatives, evaluate technologies, an...

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Join a dynamic team as a System Engineer, specializing in Linux systems and automation. You'll lead the design and maintenance of provisioning workflows, configuration management, and Linux networking...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Elevate customer experiences by leading a team of engineers, providing strategic insights, and implementing innovative solutions in growth engineering and digital marketing for impactful delivery serv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of avionics sales by leading business development efforts, engaging military and commercial aerospace customers, and driving strategic growth in the Americas through innovative test s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $140K *

Unlock the potential of our partner ecosystem by designing and delivering impactful enablement programs that elevate partner performance through engaging, high-quality training experiences...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Join us to define and drive the enterprise cloud database strategy, leading architecture and modernization efforts to create scalable, reliable solutions for healthcare applications serving millions o...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in delivering innovative solutions as a Solutions Architect, guiding teams and customers through technical challenges while maximizing mission impact and enhancing customer experiences...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive transformative Salesforce solutions in higher education as a trusted advisor. Lead architecture design, align technology with institutional goals, and ensure successful delivery of Education Clo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $140K *

Transform infrastructure and deployment modernization efforts, serving as a technical cornerstone for multiple programs. Drive DevSecOps maturity and cloud adoption while ensuring secure, rapid delive...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $220K *

Lead the design and implementation of advanced systems and workflows for GTM teams. Drive technical initiatives to optimize scalability, leverage AI, and mentor engineers, ensuring robust architectura...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $150K *

Join a team that's engineering innovative cloud solutions, ensuring stability and performance while driving continuous improvement across scalable environments. Your expertise will shape the future of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$89K - $155K *

Lead the design and implementation of a UiPath automation program, establishing governance and operational standards while collaborating with a diverse team to build a Center of Excellence from the gr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$127K - $212K *

Champion secure architecture by conducting reviews and assessments for cloud and on-premise systems. Leverage your cybersecurity expertise to design solutions that align with security best practices a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Contribute to architectural guidance and technical support across diverse projects. Collaborate with teams to evaluate solutions, adapt to evolving technologies, and communicate findings effectively t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$206K - $267K *

Transform your career by leading innovative architectural strategies and governance. As a trusted advisor, you will drive technology alignment and maximize investments while mentoring cross-functional...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Transportation

$120K - $145K *

Accelerate your career by designing and optimizing secure, scalable cloud infrastructure. Collaborate with cross-functional teams to enhance operational efficiency and ensure high availability for glo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.