Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$260K *
Join a team that's driving digital transformation by managing client accounts, developing strategies, and delivering innovative technology solutions. Build long-term relationships while collaborating...
3 weeks ago
Information Security Program Manager
$105K - $120K *
Join a dynamic team to lead and enhance information security programs, ensuring compliance and risk management across diverse industries. Collaborate with executives to develop strategies that protect...
1 week ago
Platform Engineer - FedD180/FedD181
$123K - $166K *
Join a team that's dedicated to enhancing cloud platform reliability and security. As a Platform Engineer, you'll leverage your expertise in Kubernetes and CI/CD to build and maintain robust infrastru...
3 weeks ago
$80K - $95K *
Shape the future of systems administration by managing upgrades, troubleshooting, and ensuring security compliance across Linux and Windows environments. Collaborate on cloud architecture and maintain...
2 weeks ago
Technical Leader - Substation Automation
$98K - $164K *
Explore innovative technical architectures and solutions in energy management. Collaborate with teams to deliver digital substations and automation systems while engaging with customers from design to...
Reposted 2 weeks ago
$110K - $130K *
Shape the future of product design by transforming concepts into high-fidelity experiences. Collaborate with cross-functional teams to enhance user interactions through innovative prototyping and AI-a...
Reposted 1 week ago
$80K - $133K *
Lead the charge in delivering innovative full-stack solutions, collaborating with diverse teams to modernize applications on AWS using cutting-edge technologies, ensuring operational resilience and me...
Reposted 1 week ago
$80K - $133K *
Champion innovative solutions by collaborating with cross-functional teams to develop scalable, cloud-native applications. Leverage your full-stack expertise to modernize systems and deliver high-valu...
1 week ago
$94K - $107K *
Transform data governance operations by driving process adoption, supporting data stewards, and enhancing governance tools. Collaborate with teams to ensure compliance, improve workflows, and leverage...
3 weeks ago
Senior Software Engineer, Python
$170K - $200K *
Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...
Reposted 1 week ago
Sr Domain Consultant (AI Security)
$232K - $320K *
Empower your career by providing expert guidance in AI security solutions. Lead technical validations, influence product roadmaps, and architect comprehensive security strategies to protect AI applica...
2 weeks ago
$98K - $206K *
Join a dynamic team as a Senior CSfC Systems Engineer, deploying cutting-edge networking solutions across the U.S. and globally. Leverage your expertise in virtualization and data center architecture...
Reposted 2 weeks ago
Vice President of Information Security and Infrastructure
$240K *
Lead enterprise cybersecurity and infrastructure initiatives, advising executive leadership on risk management and technology investments. Shape policies and governance to ensure a secure, resilient t...
Today
Business Development & Growth Manager - Federal & B2B
$150K - $160K *
Drive revenue growth by identifying and developing federal and B2B opportunities in cybersecurity. Own the business development lifecycle, build strategic partnerships, and leverage compliance experti...
4 weeks ago
Infrastructure Security Engineer (Senior/Principal)
$170K - $325K *
Elevate your career by securing and managing the transition to a hybrid-cloud infrastructure. Own identity management, cloud security, and developer tooling while leading incident response and threat...
1 week ago
Senior Software Engineer, Biggy Engineering
$187K - $220K *
Unlock potential by designing and building AI-powered solutions to enhance enterprise IT operations, collaborating directly with customers and driving impactful product features across backend and aut...
Reposted 2 days ago
Senior Project Manager - Industrial & Manufacturing
$100K - $120K *
Explore a leadership role for large-scale projects, driving success through effective planning, risk management, and client relations while ensuring safety and financial performance throughout the pro...
Reposted 3 weeks ago
Senior Systems Engineer - ArcGIS Enterprise | TS/SCI
$156K - $239K *
Lead the charge in deploying and optimizing enterprise ArcGIS environments, managing complex migrations, and troubleshooting infrastructure issues while mentoring engineers and advising on technical d...
2 weeks ago
$122K - $183K *
Elevate user growth and monetization through thoughtful design and experimentation, collaborating closely with cross-functional teams to enhance onboarding and product engagement while maintaining hig...
Reposted 4 days ago
DAI Data Integration/Replication Engineer
$75K - $158K *
Shape the future of federal data integration by leveraging Oracle EBS expertise to create actionable insights and advanced dashboards. Collaborate with cross-functional teams and enhance government da...
Reposted 2 weeks ago
Senior AI/ML Data Model Architect
$204K - $216K *
Unlock potential by designing robust data models that empower AI systems. You will ensure data coherence and quality, bridging knowledge representation and machine learning across diverse communities...
Reposted 5 days ago
Senior Connector Development Engineer
$120K - $145K *
Join a team that's shaping the future of interconnect technology by designing innovative connector solutions. Leverage your engineering expertise to collaborate globally and meet the demands of leadin...
1 week ago
Senior Implementation Engineer
$160K *
Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...
6 days ago
Senior Solutions Engineer - East
$134K - $197K *
The Senior Sales Engineer at Obsidian Security will drive and manage the technical evaluation stage of the sales process while mentoring the team. This role requires expertise in SaaS security challen...
Reposted 2 weeks ago
$112K - $126K *
Elevate AI capabilities by building and maintaining governed solutions. Collaborate cross-functionally to translate business needs into technical designs, ensuring ethical AI use and robust integratio...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.