Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Forward Deployed Engineer - AI Security
$138K - $207K *
Elevate customer success by leading technical onboarding and implementation efforts. Collaborate cross-functionally to drive adoption and ensure timely value delivery in a fast-paced AI security envir...
3 weeks ago
Forward Deployed Engineer - AI Security
$138K - $207K *
Help us drive customer success by leading technical onboarding and implementation efforts, ensuring seamless post-sales support, and collaborating cross-functionally to enhance the customer journey in...
3 weeks ago
Forward Deployed Engineer - AI Security
$152K - $228K *
Help us drive customer success by leading technical onboarding and implementation efforts. Collaborate cross-functionally to ensure seamless post-sales support and foster long-term partnerships in a f...
3 weeks ago
Automation Engineer (Cisco CNC Upgrade)
$77K - $118K *
Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...
Reposted 1 week ago
$115K - $130K *
Transform the contracting process by managing the lifecycle of agreements, ensuring efficient execution while balancing risk and compliance. Collaborate with cross-functional teams to support business...
3 weeks ago
$185K - $231K *
Join a team that's redefining digital experiences by architecting scalable, resilient systems. Collaborate across teams to enhance performance and reliability while leveraging AI tools to drive innova...
3 weeks ago
Compliance & Regulatory Counsel
$180K - $200K *
Manage compliance and regulatory functions for a global SaaS provider, advising on laws impacting enterprise clients. Collaborate cross-functionally to ensure timely compliance and develop best practi...
2 weeks ago
Enterprise Implementation Engineer
$100K - $120K *
Elevate customer success by implementing privacy-first healthcare marketing solutions. As an Implementation Engineer, you'll guide clients through technical setups, ensuring optimal performance and co...
3 weeks ago
Software Engineer II - Cloud-Native Agent Harness (Mecatl)
$157K - $192K *
Develop and enhance a cloud-native agent harness, ensuring secure, reliable, and efficient operations. Collaborate with a dynamic team to deliver features, fix bugs, and innovate using AI throughout t...
Today
Senior Entity Resolution Engineer
$160K - $195K *
Unlock your potential by building advanced entity matching solutions. Collaborate with a dedicated team to transform complex data into actionable insights, ensuring transparency and accuracy in every...
Reposted today
$80K - $95K *
Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...
1 week ago
$125K - $150K *
Shape the future of security by engineering robust controls for endpoints and email. As a Staff Security Engineer, you'll enhance our security posture, mentor peers, and ensure compliance in a regulat...
3 weeks ago
Senior Contact Center Engineer
$93K - $150K *
Support and optimize cloud-based contact center platforms, ensuring service availability and excellent customer experience. Collaborate with teams to troubleshoot complex issues and enhance operationa...
1 week ago
Salesforce Technical Architect
$94K - $266K *
Elevate your career by joining a dynamic team focused on innovative reporting solutions. Collaborate with business users and technical experts to design impactful dashboards and dataflows, driving suc...
2 weeks ago
Security Engineer Lead, Security Foundations
$160K - $190K *
Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...
1 week ago
Senior Global Solutions Architect
$108K - $251K *
Empower customer success by leading the design and implementation of AI and CCaaS solutions. Collaborate with cross-functional teams to create scalable architectures that enhance customer experience a...
Yesterday
$110K - $130K *
Transform enterprise VoIP infrastructure by leading design, engineering, and compliance efforts. Manage complex incidents, mentor technicians, and drive modernization projects while ensuring optimal p...
3 weeks ago
$95K - $115K *
Shape the future of complex industrial projects by leading multidisciplinary design coordination and driving excellence in collaboration between clients, management, and engineering teams for successf...
Reposted 2 weeks ago
Systems Engineer, Manager - Operations
$121K - $164K *
Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...
1 week ago
Systems Engineer - Data & Automation
$75K - $158K *
Innovate solutions by leveraging your expertise in data automation and systems engineering to enhance operational efficiency and support enterprise financial management systems...
Yesterday
Application Security Architect - AI Harness
$130K - $155K *
Lead the charge in shaping secure software development practices by architecting an innovative CI/CD-integrated AI code evaluation harness to enhance application security and developer trust while ens...
Reposted today
$110K - $130K *
Elevate your career by partnering with clients to enhance their security posture. Utilize your technical know-how and communication skills to identify risks, develop tailored solutions, and ensure rob...
Reposted today
$110K - $135K *
Unlock excellence in PCB design and manufacturing by leading DFM initiatives, developing complex multilayer layouts, and shaping best practices across engineering teams to enhance product performance...
2 weeks ago
Senior Director, Dedicated Infrastructure & Platforms
$279K - $349K *
Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...
1 week ago
$110K - $130K *
Join a dynamic team as a SOC Engineer, where you'll onboard customers into managed security services, configure Microsoft security tools, and ensure reliable telemetry across diverse environments, all...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.